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Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.

Found 136 products of "Topoisomerase"

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  • Razoxane
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    Razoxane

    CAS:
    <p>Razoxane is used as an antimitotic agent with immunosuppressive properties.</p>
    Formula:C11H16N4O4
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:268.27

    Ref: TM-T26046

  • 1,4-Naphthoquinone
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    1,4-Naphthoquinone

    CAS:
    <p>1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.</p>
    Formula:C10H6O2
    Purity:99.24% - 99.56%
    Color and Shape:Solid
    Molecular weight:158.15

    Ref: TM-T7048

  • Bimolane
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    Bimolane

    CAS:
    Bimolane is a topoisomerase II inhibitor.
    Formula:C20H32N6O6
    Purity:99.13% - 99.29%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T3481

  • Doxorubicin
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    Doxorubicin

    CAS:
    Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
    Formula:C27H29NO11
    Purity:99.31%
    Color and Shape:Red Crystalline Solid Solid
    Molecular weight:543.52

    Ref: TM-T1456

  • (±)-10-Hydroxycamptothecin
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    (±)-10-Hydroxycamptothecin

    CAS:
    <p>(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.</p>
    Formula:C20H16N2O5
    Purity:98% - 99.06%
    Color and Shape:Solid
    Molecular weight:364.35

    Ref: TM-T1521

  • IndiMitecan
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    IndiMitecan

    CAS:
    <p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>
    Formula:C25H21N3O6
    Purity:98.53%
    Color and Shape:Soild
    Molecular weight:459.45

    Ref: TM-T60200

  • Exatecan
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    Exatecan

    CAS:
    <p>Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in</p>
    Formula:C24H22FN3O4
    Purity:99.64% - 99.84%
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T11249

  • PNU-159682
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    PNU-159682

    CAS:
    <p>PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.</p>
    Formula:C32H35NO13
    Purity:98.24%
    Color and Shape:Solid
    Molecular weight:641.62

    Ref: TM-T16557

  • Camptothecin
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    Camptothecin

    CAS:
    <p>Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.</p>
    Formula:C20H16N2O4
    Purity:99.52% - 99.88%
    Color and Shape:Solid Powder
    Molecular weight:348.35

    Ref: TM-T1123

  • Ellipticine
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    Ellipticine

    CAS:
    <p>Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.</p>
    Formula:C17H14N2
    Purity:97.26% - 99.88%
    Color and Shape:Solid
    Molecular weight:246.31

    Ref: TM-T1166

  • Amsacrine
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    Amsacrine

    CAS:
    <p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>
    Formula:C21H19N3O3S
    Purity:99.2%
    Color and Shape:Yellow Crystalline Powder Solid
    Molecular weight:393.46

    Ref: TM-T1206

  • Daniquidone
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    Daniquidone

    CAS:
    <p>Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasms</p>
    Formula:C15H11N3O
    Purity:98.39% - 99.52%
    Color and Shape:Solid
    Molecular weight:249.27

    Ref: TM-T68896

  • PluriSIn #2
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    PluriSIn #2

    CAS:
    <p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>
    Formula:C11H8FN3O3
    Purity:98% - 99.79%
    Color and Shape:Solid
    Molecular weight:249.2

    Ref: TM-T36301

  • BNS-22
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    BNS-22

    CAS:
    <p>BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.</p>
    Formula:C24H25NO5
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:407.46

    Ref: TM-T62037

  • Exatecan mesylate dihydrate
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    Exatecan mesylate dihydrate

    CAS:
    <p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>
    Formula:C25H30FN3O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:567.58

    Ref: TM-T78630

  • Aldoxorubicin
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    Aldoxorubicin

    CAS:
    Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.
    Formula:C37H42N4O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:750.75

    Ref: TM-T11090L

  • Pegamotecan
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    Pegamotecan

    CAS:
    <p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>
    Formula:C52H48N6O14
    Purity:96.40% - 97.83%
    Color and Shape:Solid
    Molecular weight:980.984

    Ref: TM-T24610

  • Pyrazoloacridine
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    Pyrazoloacridine

    CAS:
    <p>Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.</p>
    Formula:C19H21N5O3
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:367.4

    Ref: TM-T28475

  • 9-Chloromethyl-10-hydroxy-11-F-Camptothecin
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    9-Chloromethyl-10-hydroxy-11-F-Camptothecin

    CAS:
    <p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>
    Formula:C22H18ClFN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.84

    Ref: TM-T79883

  • Ac-Exatecan
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    Ac-Exatecan

    CAS:
    <p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>
    Formula:C26H24FN3O5
    Purity:97.09%
    Color and Shape:Solid
    Molecular weight:477.48

    Ref: TM-T77901