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Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.

Found 140 products of "Topoisomerase"

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  • Amsacrine hydrochloride
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    Amsacrine hydrochloride

    CAS:
    Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.
    Formula:C21H20ClN3O3S
    Purity:99.05% - 99.92%
    Color and Shape:Solid
    Molecular weight:429.92

    Ref: TM-T5820

  • IndiMitecan
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    IndiMitecan

    CAS:
    <p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>
    Formula:C25H21N3O6
    Purity:98.53%
    Color and Shape:Soild
    Molecular weight:459.45

    Ref: TM-T60200

  • (±)-10-Hydroxycamptothecin
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    (±)-10-Hydroxycamptothecin

    CAS:
    <p>(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.</p>
    Formula:C20H16N2O5
    Purity:98% - 99.06%
    Color and Shape:Solid
    Molecular weight:364.35

    Ref: TM-T1521

  • Exatecan
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    Exatecan

    CAS:
    Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in
    Formula:C24H22FN3O4
    Purity:99.69% - 99.91%
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T11249

  • Doxorubicin
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    Doxorubicin

    CAS:
    Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
    Formula:C27H29NO11
    Purity:99.31%
    Color and Shape:Red Crystalline Solid Solid
    Molecular weight:543.52

    Ref: TM-T1456

  • PNU-159682
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    PNU-159682

    CAS:
    PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.
    Formula:C32H35NO13
    Purity:98.24%
    Color and Shape:Solid
    Molecular weight:641.62

    Ref: TM-T16557

  • Ellipticine
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    Ellipticine

    CAS:
    Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.
    Formula:C17H14N2
    Purity:97.26% - 99.88%
    Color and Shape:Solid
    Molecular weight:246.31

    Ref: TM-T1166

  • Camptothecin
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    Camptothecin

    CAS:
    Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.
    Formula:C20H16N2O4
    Purity:99.52% - 99.88%
    Color and Shape:Solid Powder
    Molecular weight:348.35

    Ref: TM-T1123

  • Daniquidone
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    Daniquidone

    CAS:
    Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasms
    Formula:C15H11N3O
    Purity:98.39% - 99.52%
    Color and Shape:Solid
    Molecular weight:249.27

    Ref: TM-T68896

  • BNS-22
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    BNS-22

    CAS:
    BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.
    Formula:C24H25NO5
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:407.46

    Ref: TM-T62037

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    IID432

    IID432 can inhibit the topoisomerase II of Trypanosoma cruzi, with an EC50 value of 8 nM.
    Formula:C19H19N7O
    Molecular weight:361.4

    Ref: TM-T210488

  • T638
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    T638

    CAS:
    T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.
    Formula:C18H16N4OS
    Color and Shape:Solid
    Molecular weight:336.41

    Ref: TM-T88452

  • Exatecan mesylate dihydrate
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    Exatecan mesylate dihydrate

    CAS:
    <p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>
    Formula:C25H30FN3O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:567.58

    Ref: TM-T78630

  • PluriSIn #2
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    PluriSIn #2

    CAS:
    PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.
    Formula:C11H8FN3O3
    Purity:98% - 99.79%
    Color and Shape:Solid
    Molecular weight:249.2

    Ref: TM-T36301

  • Amsacrine
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    Amsacrine

    CAS:
    <p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>
    Formula:C21H19N3O3S
    Purity:99.2%
    Color and Shape:Yellow Crystalline Powder Solid
    Molecular weight:393.46

    Ref: TM-T1206

  • Aldoxorubicin
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    Aldoxorubicin

    CAS:
    Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.
    Formula:C37H42N4O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:750.75

    Ref: TM-T11090L

  • Pyrazoloacridine
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    Pyrazoloacridine

    CAS:
    Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.
    Formula:C19H21N5O3
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:367.4

    Ref: TM-T28475

  • Pegamotecan
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    Pegamotecan

    CAS:
    Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell
    Formula:C52H48N6O14
    Purity:96.40% - 97.83%
    Color and Shape:Solid
    Molecular weight:980.984

    Ref: TM-T24610

  • Pradofloxacin
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    Pradofloxacin

    CAS:
    Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.
    Formula:C21H21FN4O3
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:396.41

    Ref: TM-T81412

  • Topoisomerase inhibitor 2
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    Topoisomerase inhibitor 2

    CAS:
    <p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>
    Formula:C23H23N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.46

    Ref: TM-T78717

  • 9-Chloromethyl-10-hydroxy-11-F-Camptothecin
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    9-Chloromethyl-10-hydroxy-11-F-Camptothecin

    CAS:
    9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential
    Formula:C22H18ClFN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.84

    Ref: TM-T79883

  • Topoisomerase I inhibitor 9
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    Topoisomerase I inhibitor 9

    CAS:
    Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value
    Formula:C23H15Br2FN2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.19

    Ref: TM-T80967

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).
    Formula:C21H19F3N4O6S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:512.46

    Ref: TM-T13231L

  • Anticancer agent 216
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    Anticancer agent 216

    CAS:
    Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.
    Formula:C23H21N3O6
    Color and Shape:Solid
    Molecular weight:435.43

    Ref: TM-T88220

  • NH2-methylpropanamide-Exatecan TFA
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    NH2-methylpropanamide-Exatecan TFA

    CAS:
    Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.
    Formula:C30H30F4N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:634.58

    Ref: TM-T77889

  • Ac-Exatecan
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    Ac-Exatecan

    CAS:
    <p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>
    Formula:C26H24FN3O5
    Purity:97.09%
    Color and Shape:Solid
    Molecular weight:477.48

    Ref: TM-T77901

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    SDOX

    CAS:
    SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.
    Formula:C69H97NO20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1324.63

    Ref: TM-T74364

  • LMP744 hydrochloride
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    LMP744 hydrochloride

    CAS:
    <p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>
    Formula:C24H25ClN2O7
    Purity:99.59% - 99.85%
    Color and Shape:Solid
    Molecular weight:488.92

    Ref: TM-T11872L

  • ARN-21934
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    ARN-21934

    CAS:
    ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.
    Formula:C21H24N6
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:360.46

    Ref: TM-T36968

  • Topoisomerase II inhibitor 18
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    Topoisomerase II inhibitor 18

    CAS:
    <p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>
    Formula:C20H21N3OS
    Color and Shape:Solid
    Molecular weight:351.47

    Ref: TM-T87552

  • Karenitecin
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    Karenitecin

    CAS:
    <p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>
    Formula:C25H28N2O4Si
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.59

    Ref: TM-T14703

  • Intoplicine
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    Intoplicine

    CAS:
    Intoplicine is an inhibitor of DNA topoisomerase I and II.
    Formula:C21H24N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:348.44

    Ref: TM-T15586

  • TH1338
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    TH1338

    CAS:
    <p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>
    Formula:C22H21N3O4
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T28959

  • Topotecan acetate
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    Topotecan acetate

    CAS:
    Topotecan acetate is an inhibitor of topoisomerase.
    Formula:C25H27N3O7
    Color and Shape:Solid
    Molecular weight:481.498

    Ref: TM-T204761

  • LMP517
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    LMP517

    CAS:
    LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].
    Formula:C22H19FN2O5
    Color and Shape:Solid
    Molecular weight:410.4

    Ref: TM-T86817

  • Topoisomerase I/II inhibitor 7
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    Topoisomerase I/II inhibitor 7

    CAS:
    <p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>
    Formula:C18H13ClN2O3
    Color and Shape:Solid
    Molecular weight:340.76

    Ref: TM-T204827

  • Anticancer agent 215
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    Anticancer agent 215

    CAS:
    Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.
    Formula:C23H22FN3O4
    Color and Shape:Solid
    Molecular weight:423.44

    Ref: TM-T88193

  • Gimatecan
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    Gimatecan

    CAS:
    Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
    Formula:C25H25N3O5
    Purity:98.47%
    Color and Shape:Solid
    Molecular weight:447.48

    Ref: TM-T21319

  • Saintopin
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    Saintopin

    CAS:
    Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].
    Formula:C18H10O7
    Color and Shape:Solid
    Molecular weight:338.27

    Ref: TM-T87353

  • Edotecarin
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    Edotecarin

    CAS:
    <p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>
    Formula:C29H28N4O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:608.55

    Ref: TM-T15200