DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Found 455 products of "DNA Methyltransferase"
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(2R)-Octyl-α-hydroxyglutarate sodium
CAS:(Sodium) (2R)-Octyl-α-hydroxyglutarate is the sodium salt variant of (2R)-Octyl-α-hydroxyglutarate, which has been shown to possess anti-inflammatory properties [1].Formula:C13H23NaO5Molecular weight:282.31YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFormula:C23H34N4O3Color and Shape:SolidMolecular weight:414.54MMSET-IN-1
CAS:MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .Formula:C18H29N7O5Purity:98%Color and Shape:SolidMolecular weight:423.47NSD2-PWWP1-IN-1
CAS:NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.Formula:C28H30N4Color and Shape:SolidMolecular weight:422.565W4275
CAS:W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Formula:C25H36N6O3Color and Shape:SolidMolecular weight:468.59O6BTG-C8-αGlu
CAS:O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.Formula:C24H34BrN5O7SColor and Shape:SolidMolecular weight:616.525AMI-408
CAS:AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formula:C20H13Cl2N6NaO5SColor and Shape:SolidMolecular weight:543.32PRMT5-IN-48
CAS:PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formula:C30H37N5O3Color and Shape:SolidMolecular weight:515.646EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formula:C19H19FN8OColor and Shape:SolidMolecular weight:394.41CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Formula:C24H34Cl2N4O2Color and Shape:SolidMolecular weight:481.46PRMT5-IN-1
CAS:PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).Formula:C19H19ClN4O5Purity:98%Color and Shape:SolidMolecular weight:418.83Dot1L-IN-1
CAS:The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.Formula:C32H36ClN9O2SPurity:98%Color and Shape:SolidMolecular weight:646.21HBI-2375
CAS:HBI-2375 (HYBI-084) is a selective inhibitor that penetrates the blood-brain barrier and is orally active, targeting the MLL1-WDR5 interaction. It inhibits WDR5 with an IC50 of 4.48 nM and demonstrates antiproliferative activity in MV4;11 leukemia cells with an IC50 of 3.17 µM. Furthermore, HBI-2375 disrupts histone methyltransferase activity in cancer cells and is useful for researching leukemia, glioma, and glioblastoma.Formula:C29H36ClF2N9O2Color and Shape:SolidMolecular weight:616.11NSD2-PWWP1-IN-2
CAS:NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formula:C29H30N4Color and Shape:SolidMolecular weight:434.575RL5a
CAS:RL5a (compound C23) is a novel inhibitor of SETD8.Formula:C17H19N3OColor and Shape:SolidMolecular weight:281.35PRMT5-IN-49
CAS:PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formula:C19H22N2O2Color and Shape:SolidMolecular weight:310.39PRMT5-IN-18
CAS:PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formula:C32H42N4O4Color and Shape:SolidMolecular weight:546.70PRMT5-IN-37
CAS:PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formula:C21H15F4N5O2Color and Shape:SolidMolecular weight:445.37EZH2-IN-12
EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.Formula:C23H23Cl2N3O3Color and Shape:SolidMolecular weight:460.35RK-0080552
CAS:RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Formula:C12H6N6O2Color and Shape:SolidMolecular weight:266.215Pociredir
CAS:Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.Formula:C22H18FN5O2Color and Shape:SolidMolecular weight:403.41PRMT5-IN-50
CAS:PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formula:C26H23F3N6OColor and Shape:SolidMolecular weight:492.496GSK3368715 3HCl
CAS:GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formula:C20H41Cl3N4O2Purity:98%Color and Shape:SolidMolecular weight:475.92MM-589 TFA
CAS:MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C30H45F3N8O7Purity:98%Color and Shape:SolidMolecular weight:686.72WDR5-IN-5
CAS:WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.Formula:C29H29F3N6OColor and Shape:SolidMolecular weight:534.58HLCL-61
CAS:HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formula:C23H24N2OColor and Shape:SolidMolecular weight:344.45PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formula:C25H24N4OColor and Shape:SolidMolecular weight:396.48PRMT5-IN-21
PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.Formula:C18H18F2N6O3Color and Shape:SolidMolecular weight:404.37MS8511
CAS:<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formula:C28H41N5O3Color and Shape:SolidMolecular weight:495.66MRK-740-NC
CAS:MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Formula:C25H31N5O3Color and Shape:SolidMolecular weight:449.55rel-A-395 hydrochloride
CAS:rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formula:C26H36ClFN4O2SColor and Shape:SolidMolecular weight:523.11WIZ degrader 1
CAS:WIZ degrader 1 (Compound 141) is a degrader of the wide-interval zinc-finger motif (WIZ) with an AC50 of 2 nM. It can induce the expression of fetal hemoglobin (HbF), exhibiting an EC50 value of 6 mM. WIZ degrader 1 is used in the research of genetic blood disorders.Formula:C25H33F2N5O2Molecular weight:473.56NSD2-PWWP1-IN-3
CAS:<p>NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.</p>Formula:C34H39N5O2Color and Shape:SolidMolecular weight:549.706HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formula:C18H19N3O3Color and Shape:SolidMolecular weight:325.36PRMT5-IN-44
CAS:PRMT5-IN-44 (compound 12) is an inhibitor of PRMT5, specifically utilized in cancer research.Formula:C23H19F4N5O2Molecular weight:473.42SGC6870N
CAS:<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Formula:C23H21BrN2O2SMolecular weight:469.39PRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.Formula:C19H20Cl2N4O5Color and Shape:SolidMolecular weight:455.29Octyl-α-hydroxyglutarate
CAS:<p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>Formula:C13H24O5Molecular weight:260.33ZL-28-6
CAS:ZL-28-6, a type I PRMT inhibitor (IC50: 18 nM), effectively targets CARM1 (a member of PRMT) within cells and is suitable for cancer research [1].Formula:C18H22Cl2N2OMolecular weight:353.29(1-Nitroethene-1,2-diyl)dibenzene
CAS:(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formula:C14H11NO2Color and Shape:SolidMolecular weight:225.24MU1656
CAS:MU1656 is a selective inhibitor of histone methyltransferase DOT1L, which significantly inhibits cancer cell proliferation in hematological malignancies.Formula:C32H45N7O2Purity:96.92%Color and Shape:SolidMolecular weight:559.75MM-589
CAS:MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C28H44N8O5Purity:98%Color and Shape:SolidMolecular weight:572.70PRMT5-IN-32
CAS:PRMT5-IN-32, an inhibitor of PRMT5, inhibits HCT116 cell proliferation with an IC50 of 0.13 μM [1].Formula:C27H21F4N5O2Molecular weight:523.48EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Formula:C22H29FN4O2Purity:99.58%Color and Shape:SolidMolecular weight:400.49LLY-283
CAS:LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.Formula:C17H18N4O4Purity:99.49%Color and Shape:SolidMolecular weight:342.35AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Formula:C22H19F3N4O3Purity:99.52%Color and Shape:SolidMolecular weight:444.41GSK3368715 dihydrochloride
CAS:GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.Formula:C20H40Cl2N4O2Purity:99.66% - 99.66%Color and Shape:SolidMolecular weight:439.46ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formula:C26H25FN6OPurity:98.08%Color and Shape:SolidMolecular weight:456.52Sinefungin
CAS:Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFormula:C15H23N7O5Purity:98% - 98.12%Color and Shape:SolidMolecular weight:381.39BRD0639
CAS:BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Formula:C21H22ClN5O4SPurity:99.85%Color and Shape:SolidMolecular weight:475.95EHMT2-IN-2
CAS:EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.Formula:C21H22N6OColor and Shape:SolidMolecular weight:374.44CARM1-IN-1 hydrochloride
CAS:CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.Formula:C26H22Br2ClNO3Color and Shape:SolidMolecular weight:591.72BLL5 Maleate
CAS:BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.Formula:C21H21N3Purity:98%Color and Shape:SolidMolecular weight:315.41Igermetostat
CAS:<p>Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].</p>Formula:C32H46N4O4Purity:98%Color and Shape:SolidMolecular weight:550.73BBDDL2059
CAS:<p>BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.</p>Formula:C27H36N4O4SPurity:98%Color and Shape:SolidMolecular weight:512.66
