DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Found 422 products of "DNA Methyltransferase"
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PRMT5-IN-10
CAS:<p>PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.</p>Formula:C13H17N5O4Color and Shape:SolidMolecular weight:307.31EZH2-IN-7
CAS:<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Formula:C31H37D2N5O3SColor and Shape:SolidMolecular weight:563.755-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Formula:C8H12N4O3SColor and Shape:SolidMolecular weight:244.27Lobelane Hydrochloride
CAS:<p>Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.</p>Formula:C22H30ClNColor and Shape:SolidMolecular weight:343.93Fagaronine chloride
CAS:<p>Fagaronine chloride is a potent inhibitor of Topoisomerases I.</p>Formula:C21H20ClNO4Color and Shape:SolidMolecular weight:385.84DC_501
CAS:<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Formula:C25H23Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:452.38Prospasmine
CAS:<p>Prospasmine is an anticholinergic.</p>Formula:C17H28ClNO2Purity:98%Color and Shape:SolidMolecular weight:313.87Setin-1
CAS:<p>Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.</p>Formula:C29H21F3N2O2Purity:98%Color and Shape:SolidMolecular weight:486.48DCE_254
CAS:<p>DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Formula:C21H17N9OSPurity:98%Color and Shape:SolidMolecular weight:443.48GSK926
CAS:<p>GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.</p>Formula:C29H35N7O2Color and Shape:SolidMolecular weight:513.63Arazine
CAS:<p>Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.</p>Formula:C20H33NO3SPurity:90%Color and Shape:SolidMolecular weight:367.55JNJ-7925476 free base
CAS:<p>JNJ-7925476 is an TRI antidepressant agent.</p>Formula:C20H19NPurity:98%Color and Shape:SolidMolecular weight:273.37(R)-OR-S1
CAS:<p>(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.</p>Formula:C26H34BrN3O4Purity:98%Color and Shape:SolidMolecular weight:532.47MS453
CAS:<p>MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.</p>Formula:C20H27N5O3Color and Shape:SolidMolecular weight:385.46S-Aristeromycinylhomocysteine
CAS:<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>Formula:C15H22N6O4SColor and Shape:SolidMolecular weight:382.44ZLD10A
CAS:<p>ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.</p>Formula:C37H48N4O4Purity:98%Color and Shape:SolidMolecular weight:612.8LEM-14-1189
CAS:<p>LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.</p>Formula:C35H34N6O5S2Purity:98.06%Color and Shape:SolidMolecular weight:682.81Valemetostat tosylate
CAS:<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Formula:C33H42ClN3O7SPurity:98%Color and Shape:SolidMolecular weight:660.22MM-102
CAS:<p>MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.</p>Formula:C35H49F2N7O4Purity:98.77% - 99.99%Color and Shape:SolidMolecular weight:669.8EPZ032597
CAS:<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Formula:C20H23N7OPurity:99.70%Color and Shape:SolidMolecular weight:377.44PRMT4-IN-1
CAS:<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Formula:C23H28FN3OPurity:98%Color and Shape:SolidMolecular weight:381.49SMYD2-IN-1
CAS:<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Formula:C25H25Cl2F2N7O2Purity:98%Color and Shape:SolidMolecular weight:564.41EML741
CAS:<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Formula:C31H49N5O2Purity:98%Color and Shape:SolidMolecular weight:523.75EZM 2302
CAS:<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Formula:C29H37ClN6O5Purity:97.47% - ≥98%Color and Shape:SolidMolecular weight:585.09Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Formula:C27H24N8OPurity:98%Color and Shape:SolidMolecular weight:476.53Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Formula:C18H24N9NaO10PPurity:98%Color and Shape:SolidMolecular weight:580.407GNA002
CAS:<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Formula:C42H55NO8Purity:98%Color and Shape:SolidMolecular weight:701.89ZLD1039
CAS:<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Formula:C36H48N6O3Purity:99.5%Color and Shape:SolidMolecular weight:612.8PRMT5-IN-2
CAS:<p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>Formula:C17H16ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:394.78Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Formula:C9H16N2O6Purity:98%Color and Shape:SolidMolecular weight:248.23DC_517
CAS:<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Formula:C33H35N3O2Color and Shape:SolidMolecular weight:505.65DW14800
CAS:<p>DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.</p>Formula:C31H36N4O3Purity:99.55% - 99.68%Color and Shape:SolidMolecular weight:512.64Cedazuridine
CAS:<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Formula:C9H14F2N2O5Purity:99.66%Color and Shape:SolidMolecular weight:268.21Procainamide
CAS:<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Formula:C13H21N3OPurity:99.92% - 99.92%Color and Shape:SolidMolecular weight:235.33TM2-115
CAS:<p>TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].</p>Formula:C28H38N6O2Purity:97.67%Color and Shape:SolidMolecular weight:490.64CARM1-IN-1
CAS:<p>CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.</p>Formula:C26H21Br2NO3Purity:98.24%Color and Shape:SolidMolecular weight:555.26WDR5-0102
CAS:<p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>Formula:C18H19ClN4O3Purity:98.03%Color and Shape:SolidMolecular weight:374.82UNC0321
CAS:<p>UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.</p>Formula:C27H45N7O3Purity:99.80%Color and Shape:SolidMolecular weight:515.69TNG908
CAS:<p>TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.</p>Formula:C21H23N5O2SPurity:98.08% - 98.24%Color and Shape:SolidMolecular weight:409.51MS0124
CAS:<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Formula:C20H29N5O3Purity:98.97%Color and Shape:SolidMolecular weight:387.48Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Formula:C16H13Cl2N3OPurity:99.22%Color and Shape:SolidMolecular weight:334.2CPUY074020
CAS:<p>CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.</p>Formula:C25H28N4O2Purity:98.64%Color and Shape:SolidMolecular weight:416.52LEM-14
CAS:<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Formula:C25H26N4O4SPurity:98.3%Color and Shape:SolidMolecular weight:478.56EZH2-IN-13
CAS:<p>EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.</p>Formula:C34H45N5O3Purity:98.3%Color and Shape:SolidMolecular weight:571.75GSK-A
CAS:<p>GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.</p>Formula:C21H25N5O2Color and Shape:SolidMolecular weight:379.46PRMT5-IN-25
CAS:<p>PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1</p>Formula:C24H21F3N6OPurity:98%Color and Shape:SolidMolecular weight:466.46MAK683-CH2CH2COOH
CAS:<p>MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.</p>Formula:C23H21FN6O3Purity:98%Color and Shape:SolidMolecular weight:448.45DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formula:C37H39N7OColor and Shape:SolidMolecular weight:597.75CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Formula:C29H43Cl3N4O3Purity:98%Color and Shape:SolidMolecular weight:602.04EPZ011989 HCl(1598383-40-4 Free base)
CAS:<p>EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.</p>Formula:C35H51N5O4·HClColor and Shape:SolidMolecular weight:642.27PRMT5-IN-29
CAS:<p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>Formula:C18H20Cl3N5O5Purity:98%Color and Shape:SolidMolecular weight:492.74CARM1-IN-3
CAS:<p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>Formula:C24H32N4O2Purity:98%Color and Shape:SolidMolecular weight:408.54MS67
CAS:<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Formula:C52H59F4N9O7SColor and Shape:SolidMolecular weight:1030.14WM-586
CAS:<p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>Formula:C20H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:467.47Bisegliptin
CAS:<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Formula:C18H26FN3O3Purity:98%Color and Shape:SolidMolecular weight:351.42PRMT5-IN-28
CAS:<p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>Formula:C18H19ClN4O5Purity:98%Color and Shape:SolidMolecular weight:406.82SMYD3-IN-1
CAS:<p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>Formula:C28H31ClN4O3Purity:98%Color and Shape:SolidMolecular weight:507.02RK-701
CAS:<p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>Formula:C26H30N4O3Color and Shape:SolidMolecular weight:446.54DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Formula:C19H22N6O5SPurity:99.12% - 99.12%Color and Shape:SolidMolecular weight:446.48RK-0133114
<p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>Formula:C26H30N4O3Color and Shape:SolidMolecular weight:446.54MS023 trihydrochloride
CAS:<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Formula:C17H28Cl3N3OPurity:99.81%Color and Shape:SolidMolecular weight:396.78EZH2-IN-14
CAS:<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Formula:C31H39N7O2Color and Shape:SolidMolecular weight:541.69PRT543
CAS:<p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>Formula:C17H17ClN4O4Color and Shape:SolidMolecular weight:376.79PRMT5-IN-16
CAS:<p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>Formula:C25H34N8O2Color and Shape:SolidMolecular weight:478.59EPZ-030456
CAS:<p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>Formula:C28H34ClN5O4SColor and Shape:SolidMolecular weight:572.12GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Formula:C19H19N5OSPurity:99.87% - 99.963%Color and Shape:SolidMolecular weight:365.45UNC8153 TFA
CAS:<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Formula:C35H38F3N5O7Purity:96.44%Color and Shape:SolidMolecular weight:697.7EPZ031686
CAS:<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Formula:C26H34ClF3N4O4SPurity:99.67%Color and Shape:SolidMolecular weight:591.09PF-06726304 acetate
CAS:<p>PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.</p>Formula:C24H25Cl2N3O5Purity:98%Color and Shape:SolidMolecular weight:506.38GSK3368715 3HCl
CAS:<p>GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81</p>Formula:C20H41Cl3N4O2Purity:98%Color and Shape:SolidMolecular weight:475.92HLCL-61
CAS:<p>HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).</p>Formula:C23H24N2OColor and Shape:SolidMolecular weight:344.45(1-Nitroethene-1,2-diyl)dibenzene
CAS:<p>(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.</p>Formula:C14H11NO2Color and Shape:SolidMolecular weight:225.24RL5a
CAS:<p>RL5a (compound C23) is a novel inhibitor of SETD8.</p>Formula:C17H19N3OColor and Shape:SolidMolecular weight:281.35MMSET-IN-1
CAS:<p>MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .</p>Formula:C18H29N7O5Purity:98%Color and Shape:SolidMolecular weight:423.47Octyl-α-hydroxyglutarate
CAS:<p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>Formula:C13H24O5Molecular weight:260.33SGC6870N
CAS:<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Formula:C23H21BrN2O2SMolecular weight:469.39PRMT5-IN-50
CAS:<p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>Formula:C26H23F3N6OColor and Shape:SolidMolecular weight:492.496RK-0080552
CAS:<p>RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.</p>Formula:C12H6N6O2Color and Shape:SolidMolecular weight:266.215TDI-015051
CAS:<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formula:C22H22FN5O4SColor and Shape:SolidMolecular weight:471.505PRMT5-IN-37
CAS:<p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>Formula:C21H15F4N5O2Color and Shape:SolidMolecular weight:445.37PRMT5-IN-49
CAS:<p>PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.</p>Formula:C19H22N2O2Color and Shape:SolidMolecular weight:310.39NSD2-PWWP1-IN-2
CAS:<p>NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.</p>Formula:C29H30N4Color and Shape:SolidMolecular weight:434.575PRMT5-IN-3
CAS:<p>PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.</p>Formula:C22H23F3N4O3Color and Shape:SolidMolecular weight:448.44MS117
<p>MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].</p>Formula:C17H22N4OColor and Shape:SolidMolecular weight:298.38SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formula:C20H20N6O5SColor and Shape:SolidMolecular weight:456.48EZH2-IN-12
<p>EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.</p>Formula:C23H23Cl2N3O3Color and Shape:SolidMolecular weight:460.35PRMT5-IN-19
<p>PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.</p>Formula:C25H24N4OColor and Shape:SolidMolecular weight:396.48WDR5-IN-5
CAS:<p>WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.</p>Formula:C29H29F3N6OColor and Shape:SolidMolecular weight:534.58PRMT5-IN-1 hydrochloride
<p>PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.</p>Formula:C19H20Cl2N4O5Color and Shape:SolidMolecular weight:455.29NSD2-PWWP1-IN-3
CAS:<p>NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.</p>Formula:C34H39N5O2Color and Shape:SolidMolecular weight:549.706Pociredir
CAS:<p>Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.</p>Formula:C22H18FN5O2Color and Shape:SolidMolecular weight:403.41PRMT5-MTA-IN-3
CAS:<p>PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.</p>Formula:C19H17F3N6O3Color and Shape:SolidMolecular weight:434.372MM-589
CAS:<p>MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>Formula:C28H44N8O5Purity:98%Color and Shape:SolidMolecular weight:572.70MS8511
CAS:<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formula:C28H41N5O3Color and Shape:SolidMolecular weight:495.66PRMT5-IN-21
<p>PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.</p>Formula:C18H18F2N6O3Color and Shape:SolidMolecular weight:404.37O6BTG-C8-αGlu
CAS:<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formula:C24H34BrN5O7SColor and Shape:SolidMolecular weight:616.525NSD2-PWWP1-IN-1
CAS:<p>NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.</p>Formula:C28H30N4Color and Shape:SolidMolecular weight:422.565EED ligand 1
<p>EED ligand 1: potent PRC2 inhibitor targeting EED subunit.</p>Formula:C19H19FN8OColor and Shape:SolidMolecular weight:394.41MS8815
CAS:<p>MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.</p>Formula:C65H87N9O8SColor and Shape:SolidMolecular weight:1154.51RU-0415529
CAS:<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formula:C21H29N3O4SColor and Shape:SolidMolecular weight:419.538
