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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • PRMT4-IN-1
    Targetmol
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    PRMT4-IN-1

    CAS:
    <p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>
    Formula:C23H28FN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:381.49

    Ref: TM-T68378

  • SMYD2-IN-1
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    SMYD2-IN-1

    CAS:
    <p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>
    Formula:C25H25Cl2F2N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:564.41

    Ref: TM-T12939

  • EML741
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    EML741

    CAS:
    <p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>
    Formula:C31H49N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:523.75

    Ref: TM-T11185

  • EZM 2302
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    EZM 2302

    CAS:
    <p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>
    Formula:C29H37ClN6O5
    Purity:97.47% - ≥98%
    Color and Shape:Solid
    Molecular weight:585.09

    Ref: TM-T5605

  • Dot1L-IN-2
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    Dot1L-IN-2

    CAS:
    <p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>
    Formula:C27H24N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:476.53

    Ref: TM-T11082

  • Guadecitabine sodium
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    Guadecitabine sodium

    CAS:
    <p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>
    Formula:C18H24N9NaO10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:580.407

    Ref: TM-T12790

  • GNA002
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    GNA002

    CAS:
    <p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>
    Formula:C42H55NO8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:701.89

    Ref: TM-T11436

  • ZLD1039
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    ZLD1039

    CAS:
    <p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>
    Formula:C36H48N6O3
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:612.8

    Ref: TM-T29231

  • PRMT5-IN-2
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    PRMT5-IN-2

    CAS:
    <p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>
    Formula:C17H16ClFN4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:394.78

    Ref: TM-T16577

  • Tetrahydrouridine
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    Tetrahydrouridine

    CAS:
    <p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>
    Formula:C9H16N2O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:248.23

    Ref: TM-T17059

  • DC_517
    Targetmol
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    DC_517

    CAS:
    <p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>
    Formula:C33H35N3O2
    Color and Shape:Solid
    Molecular weight:505.65

    Ref: TM-T15081

  • DW14800
    Targetmol
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    DW14800

    CAS:
    <p>DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.</p>
    Formula:C31H36N4O3
    Purity:99.55% - 99.68%
    Color and Shape:Solid
    Molecular weight:512.64

    Ref: TM-T11131

  • Cedazuridine
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    Cedazuridine

    CAS:
    <p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>
    Formula:C9H14F2N2O5
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:268.21

    Ref: TM-T26972

  • Procainamide
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    Procainamide

    CAS:
    <p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>
    Formula:C13H21N3O
    Purity:99.92% - 99.92%
    Color and Shape:Solid
    Molecular weight:235.33

    Ref: TM-T60322

  • TM2-115
    Targetmol
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    TM2-115

    CAS:
    <p>TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].</p>
    Formula:C28H38N6O2
    Purity:97.67%
    Color and Shape:Solid
    Molecular weight:490.64

    Ref: TM-T9004

  • CARM1-IN-1
    Targetmol
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    CARM1-IN-1

    CAS:
    <p>CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 &gt; 600 μM.</p>
    Formula:C26H21Br2NO3
    Purity:98.24%
    Color and Shape:Solid
    Molecular weight:555.26

    Ref: TM-T10682L

  • WDR5-0102
    Targetmol
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    WDR5-0102

    CAS:
    <p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>
    Formula:C18H19ClN4O3
    Purity:98.03%
    Color and Shape:Solid
    Molecular weight:374.82

    Ref: TM-T67947

  • UNC0321
    Targetmol
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    UNC0321

    CAS:
    <p>UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.</p>
    Formula:C27H45N7O3
    Purity:99.80%
    Color and Shape:Solid
    Molecular weight:515.69

    Ref: TM-T17204

  • TNG908
    Targetmol
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    TNG908

    CAS:
    <p>TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.</p>
    Formula:C21H23N5O2S
    Purity:98.08% - 98.24%
    Color and Shape:Solid
    Molecular weight:409.51

    Ref: TM-T73494

  • MS0124
    Targetmol
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    MS0124

    CAS:
    <p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>
    Formula:C20H29N5O3
    Purity:98.97%
    Color and Shape:Solid
    Molecular weight:387.48

    Ref: TM-T28112