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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • Bobcat339 hydrochloride
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    Bobcat339 hydrochloride

    CAS:
    <p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>
    Formula:C16H13Cl2N3O
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:334.2

    Ref: TM-T61012

  • CPUY074020
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    CPUY074020

    CAS:
    <p>CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.</p>
    Formula:C25H28N4O2
    Purity:98.64%
    Color and Shape:Solid
    Molecular weight:416.52

    Ref: TM-T10882

  • LEM-14
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    LEM-14

    CAS:
    <p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>
    Formula:C25H26N4O4S
    Purity:98.3%
    Color and Shape:Solid
    Molecular weight:478.56

    Ref: TM-T9006

  • EZH2-IN-13
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    EZH2-IN-13

    CAS:
    <p>EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.</p>
    Formula:C34H45N5O3
    Purity:98.3%
    Color and Shape:Solid
    Molecular weight:571.75

    Ref: TM-T64043

  • GSK-A
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    GSK-A

    CAS:
    <p>GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.</p>
    Formula:C21H25N5O2
    Color and Shape:Solid
    Molecular weight:379.46

    Ref: TM-T25471

  • PRMT5-IN-25
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    PRMT5-IN-25

    CAS:
    <p>PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1</p>
    Formula:C24H21F3N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:466.46

    Ref: TM-T78152

  • MAK683-CH2CH2COOH
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    MAK683-CH2CH2COOH

    CAS:
    <p>MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.</p>
    Formula:C23H21FN6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.45

    Ref: TM-T13765

  • DNMT-IN-3
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    DNMT-IN-3

    CAS:
    <p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>
    Formula:C37H39N7O
    Color and Shape:Solid
    Molecular weight:597.75

    Ref: TM-T86293

  • CM-579 trihydrochloride (1846570-40-8 free base)
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    CM-579 trihydrochloride (1846570-40-8 free base)

    <p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>
    Formula:C29H43Cl3N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.04

    Ref: TM-T10840

  • EPZ011989 HCl(1598383-40-4 Free base)
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    EPZ011989 HCl(1598383-40-4 Free base)

    CAS:
    <p>EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value &lt;3 nM.</p>
    Formula:C35H51N5O4·HCl
    Color and Shape:Solid
    Molecular weight:642.27

    Ref: TM-T2435L

  • PRMT5-IN-29
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    PRMT5-IN-29

    CAS:
    <p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>
    Formula:C18H20Cl3N5O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:492.74

    Ref: TM-T78172

  • CARM1-IN-3
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    CARM1-IN-3

    CAS:
    <p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>
    Formula:C24H32N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:408.54

    Ref: TM-T79007

  • MS67
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    MS67

    CAS:
    <p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>
    Formula:C52H59F4N9O7S
    Color and Shape:Solid
    Molecular weight:1030.14

    Ref: TM-T39976

  • WM-586
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    WM-586

    CAS:
    <p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>
    Formula:C20H20F3N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:467.47

    Ref: TM-T79120

  • Bisegliptin
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    Bisegliptin

    CAS:
    <p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>
    Formula:C18H26FN3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:351.42

    Ref: TM-T30472

  • PRMT5-IN-28
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    PRMT5-IN-28

    CAS:
    <p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>
    Formula:C18H19ClN4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:406.82

    Ref: TM-T79035

  • SMYD3-IN-1
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    SMYD3-IN-1

    CAS:
    <p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>
    Formula:C28H31ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:507.02

    Ref: TM-T12940

  • RK-701
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    RK-701

    CAS:
    <p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>
    Formula:C26H30N4O3
    Color and Shape:Solid
    Molecular weight:446.54

    Ref: TM-T73517

  • DY-46-2
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    DY-46-2

    CAS:
    <p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>
    Formula:C19H22N6O5S
    Purity:99.12% - 99.12%
    Color and Shape:Solid
    Molecular weight:446.48

    Ref: TM-T62643

  • RK-0133114
    Targetmol
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    RK-0133114

    <p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>
    Formula:C26H30N4O3
    Color and Shape:Solid
    Molecular weight:446.54

    Ref: TM-T73188