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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 422 products of "DNA Methyltransferase"

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  • MS023 trihydrochloride
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    MS023 trihydrochloride

    CAS:
    <p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>
    Formula:C17H28Cl3N3O
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:396.78

    Ref: TM-T77787

  • EZH2-IN-14
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    EZH2-IN-14

    CAS:
    <p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has &gt;200-fold specificity over EZH1, reducing H3K27me3 levels.</p>
    Formula:C31H39N7O2
    Color and Shape:Solid
    Molecular weight:541.69

    Ref: TM-T73134

  • PRT543
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    PRT543

    CAS:
    <p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>
    Formula:C17H17ClN4O4
    Color and Shape:Solid
    Molecular weight:376.79

    Ref: TM-T84861

  • PRMT5-IN-16
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    PRMT5-IN-16

    CAS:
    <p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>
    Formula:C25H34N8O2
    Color and Shape:Solid
    Molecular weight:478.59

    Ref: TM-T63138

  • EPZ-030456
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    EPZ-030456

    CAS:
    <p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>
    Formula:C28H34ClN5O4S
    Color and Shape:Solid
    Molecular weight:572.12

    Ref: TM-T24038

  • GSK-3484862
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    GSK-3484862

    CAS:
    <p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>
    Formula:C19H19N5OS
    Purity:99.87% - 99.963%
    Color and Shape:Solid
    Molecular weight:365.45

    Ref: TM-T11469

  • UNC8153 TFA
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    UNC8153 TFA

    CAS:
    <p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>
    Formula:C35H38F3N5O7
    Purity:96.44%
    Color and Shape:Solid
    Molecular weight:697.7

    Ref: TM-T83867

  • EPZ031686
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    EPZ031686

    CAS:
    <p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>
    Formula:C26H34ClF3N4O4S
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:591.09

    Ref: TM-TQ0263

  • PF-06726304 acetate
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    PF-06726304 acetate

    CAS:
    <p>PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.</p>
    Formula:C24H25Cl2N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:506.38

    Ref: TM-T12428

  • GSK3368715 3HCl
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    GSK3368715 3HCl

    CAS:
    <p>GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81</p>
    Formula:C20H41Cl3N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:475.92

    Ref: TM-T22342

  • HLCL-61
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    HLCL-61

    CAS:
    <p>HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).</p>
    Formula:C23H24N2O
    Color and Shape:Solid
    Molecular weight:344.45

    Ref: TM-T200932

  • (1-Nitroethene-1,2-diyl)dibenzene
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    (1-Nitroethene-1,2-diyl)dibenzene

    CAS:
    <p>(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.</p>
    Formula:C14H11NO2
    Color and Shape:Solid
    Molecular weight:225.24

    Ref: TM-T200869

  • RL5a
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    RL5a

    CAS:
    <p>RL5a (compound C23) is a novel inhibitor of SETD8.</p>
    Formula:C17H19N3O
    Color and Shape:Solid
    Molecular weight:281.35

    Ref: TM-T200589

  • MMSET-IN-1
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    MMSET-IN-1

    CAS:
    <p>MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .</p>
    Formula:C18H29N7O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.47

    Ref: TM-T12083

  • CymitQuimica logo
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    Octyl-α-hydroxyglutarate

    CAS:
    <p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>
    Formula:C13H24O5
    Molecular weight:260.33

    Ref: TM-T208704

  • CymitQuimica logo
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    SGC6870N

    CAS:
    <p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>
    Formula:C23H21BrN2O2S
    Molecular weight:469.39

    Ref: TM-T208658

  • PRMT5-IN-50
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    PRMT5-IN-50

    CAS:
    <p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>
    Formula:C26H23F3N6O
    Color and Shape:Solid
    Molecular weight:492.496

    Ref: TM-T206754

  • RK-0080552
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    RK-0080552

    CAS:
    <p>RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.</p>
    Formula:C12H6N6O2
    Color and Shape:Solid
    Molecular weight:266.215

    Ref: TM-T206998

  • TDI-015051
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    TDI-015051

    CAS:
    <p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>
    Formula:C22H22FN5O4S
    Color and Shape:Solid
    Molecular weight:471.505

    Ref: TM-T204648

  • PRMT5-IN-37
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    PRMT5-IN-37

    CAS:
    <p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>
    Formula:C21H15F4N5O2
    Color and Shape:Solid
    Molecular weight:445.37

    Ref: TM-T88137