DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Found 422 products of "DNA Methyltransferase"
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(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formula:C19H14N2O4Color and Shape:SolidMolecular weight:334.326CARM1-IN-3 dihydrochloride
<p>CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).</p>Formula:C24H34Cl2N4O2Color and Shape:SolidMolecular weight:481.46W4275
CAS:<p>W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.</p>Formula:C25H36N6O3Color and Shape:SolidMolecular weight:468.59AMI-408
CAS:<p>AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.</p>Formula:C20H13Cl2N6NaO5SColor and Shape:SolidMolecular weight:543.32PRMT5-IN-1
CAS:<p>PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).</p>Formula:C19H19ClN4O5Purity:98%Color and Shape:SolidMolecular weight:418.83Dot1L-IN-1
CAS:<p>The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.</p>Formula:C32H36ClN9O2SPurity:98%Color and Shape:SolidMolecular weight:646.21GSK3368715
CAS:<p>GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s</p>Formula:C20H38N4O2Purity:98%Color and Shape:SolidMolecular weight:366.54MM-589 TFA
CAS:<p>MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>Formula:C30H45F3N8O7Purity:98%Color and Shape:SolidMolecular weight:686.72PRMT5-IN-18
CAS:<p>PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.</p>Formula:C32H42N4O4Color and Shape:SolidMolecular weight:546.70PRMT5-IN-48
CAS:<p>PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).</p>Formula:C30H37N5O3Color and Shape:SolidMolecular weight:515.646AMG-193
CAS:<p>AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.</p>Formula:C22H19F3N4O3Purity:99.52%Color and Shape:SolidMolecular weight:444.41ORIC-944
CAS:<p>ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.</p>Formula:C26H25FN6OPurity:98.08%Color and Shape:SolidMolecular weight:456.52EZM0414
CAS:<p>EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.</p>Formula:C22H29FN4O2Purity:99.58%Color and Shape:SolidMolecular weight:400.49LLY-283
CAS:<p>LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.</p>Formula:C17H18N4O4Purity:99.49%Color and Shape:SolidMolecular weight:342.35GSK3368715 dihydrochloride
CAS:<p>GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.</p>Formula:C20H40Cl2N4O2Purity:99.66% - 99.66%Color and Shape:SolidMolecular weight:439.46BRD0639
CAS:<p>BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.</p>Formula:C21H22ClN5O4SPurity:99.85%Color and Shape:SolidMolecular weight:475.95Sinefungin
CAS:<p>Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral</p>Formula:C15H23N7O5Purity:98.12%Color and Shape:SolidMolecular weight:381.39EHMT2-IN-2
CAS:<p>EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.</p>Formula:C21H22N6OColor and Shape:SolidMolecular weight:374.44CARM1-IN-1 hydrochloride
CAS:<p>CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.</p>Formula:C26H22Br2ClNO3Color and Shape:SolidMolecular weight:591.72BLL5 Maleate
CAS:<p>BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.</p>Formula:C21H21N3Purity:98%Color and Shape:SolidMolecular weight:315.41
