DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Read more
LEM-14-1189
CAS:2987501-17-5
LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood …
Formula:
C35H34N6O5S2
Purity:
97.98%
Color and Shape:
Liquid
Molecular weight:
682.81
Ref: TM-T72979
| 1mg | 333.00 € | ||
| 5mg | 922.00 € | ||
| 10mg | 1,140.00 € | ||
| 25mg | 1,510.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
CM-579
CAS:1846570-40-8
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a …
Formula:
C29H40N4O3
Purity:
99.62%
Color and Shape:
Solid
Molecular weight:
492.65
Ref: TM-T10840L
| 1mg | 55.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 217.00 € | ||
| 50mg | 319.00 € | ||
| 100mg | 472.00 € | ||
| 1mL*10mM (DMSO) | 124.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
WDR5-0102
CAS:824960-50-1
WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 …
Formula:
C18H19ClN4O3
Purity:
97.16%
Color and Shape:
Liquid
Molecular weight:
374.82
Ref: TM-T67947
| 1mg | 77.00 € | ||
| 5mg | 169.00 € | ||
| 10mg | 274.00 € | ||
| 25mg | 550.00 € | ||
| 50mg | 792.00 € | ||
| 100mg | 1,093.00 € | ||
| 500mg | 2,175.00 € | ||
| 1mL*10mM (DMSO) | 215.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Guadecitabine sodium
CAS:929904-85-8
Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .
Formula:
C18H24N9NaO10P
Purity:
98%
Color and Shape:
Solid
Molecular weight:
580.407
Ref: TM-T12790
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Dot1L-IN-2
CAS:1940206-71-2
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 …
Formula:
C27H24N8O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
476.53
Ref: TM-T11082
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
MI-2-2
CAS:1454920-20-7
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 …
Formula:
C17H20F3N5S2
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
415.5
Ref: TM-T28036
| 1mg | 64.00 € | ||
| 5mg | To inquire |
Estimated delivery in United States, on Tuesday 22 Apr 2025
GNA002
CAS:1385035-79-9
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor …
Formula:
C42H55NO8
Purity:
98%
Color and Shape:
Solid
Molecular weight:
701.89
Ref: TM-T11436
| 25mg | 1,130.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
ZLD1039
CAS:1826865-46-6
ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts …
Formula:
C36H48N6O3
Purity:
99.82%
Color and Shape:
Solid
Molecular weight:
612.8
Ref: TM-T29231
| 1mg | 35.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 226.00 € | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Bobcat339 hydrochloride
CAS:2436747-44-1
Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and …
Formula:
C16H13Cl2N3O
Color and Shape:
Liquid
Molecular weight:
334.2
Ref: TM-T61012
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 160.00 € | ||
| 50mg | 250.00 € | ||
| 100mg | 373.00 € | ||
| 200mg | 547.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
TNG908
CAS:2760481-53-4
TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, …
Formula:
C21H23N5O2S
Purity:
98.24% - 99.79%
Color and Shape:
Liquid
Molecular weight:
409.51
Ref: TM-T73494
| 1mg | 298.00 € | ||
| 5mg | 645.00 € | ||
| 10mg | 1,008.00 € | ||
| 25mg | 1,568.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Antitumor agent-101
CAS:2848632-52-8
Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of …
Formula:
C26H38N6O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
482.62
Ref: TM-T79249
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Tuesday 6 May 2025
PRMT5-IN-28
CAS:2242753-66-6
PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, …
Formula:
C18H19ClN4O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
406.82
Ref: TM-T79035
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 6 May 2025
PRMT5-IN-25
CAS:2691869-82-4
PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) …
Formula:
C24H21F3N6O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
466.46
Ref: TM-T78152
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 6 May 2025
SMYD3-IN-1
CAS:2095160-79-3
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of …
Formula:
C28H31ClN4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
507.02
Ref: TM-T12940
| 25mg | 1,730.00 € | ||
| 50mg | 2,262.00 € | ||
| 100mg | 2,945.00 € |
Estimated delivery in United States, on Tuesday 6 May 2025
Igermetostat
CAS:2409538-60-7
Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research …
Formula:
C32H46N4O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
550.73
Ref: TM-T79849
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 6 May 2025
GSK-3484862
CAS:2170136-65-7
Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.
Formula:
C19H19N5OS
Purity:
100% - 97.83%
Color and Shape:
Solid
Molecular weight:
365.45
Ref: TM-T11469
| 1mg | 50.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 187.00 € | ||
| 25mg | 335.00 € | ||
| 50mg | 512.00 € | ||
| 100mg | 730.00 € | ||
| 500mg | 1,473.00 € | ||
| 1mL*10mM (DMSO) | 215.00 € |
Estimated delivery in United States, on Tuesday 6 May 2025
UNC8153 TFA
CAS:2929304-61-8
UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and …
Formula:
C35H38F3N5O7
Purity:
96.44%
Color and Shape:
Liquid
Molecular weight:
697.7
Ref: TM-T83867
| 1mg | 79.00 € | ||
| 5mg | 216.00 € | ||
| 10mg | 354.00 € | ||
| 25mg | 582.00 € | ||
| 50mg | 825.00 € |
Estimated delivery in United States, on Tuesday 6 May 2025
PRMT5-IN-29
CAS:2242788-69-6
PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 …
Formula:
C18H20Cl3N5O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
492.74
Ref: TM-T78172
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 6 May 2025
EPZ031686
CAS:1808011-22-4
EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and …
Formula:
C26H34ClF3N4O4S
Purity:
97.91%
Color and Shape:
Solid
Molecular weight:
591.09
Ref: TM-TQ0263
| 1mg | 111.00 € | ||
| 5mg | 250.00 € | ||
| 10mg | 376.00 € | ||
| 25mg | 748.00 € | ||
| 50mg | 1,074.00 € | ||
| 100mg | 1,444.00 € | ||
| 1mL*10mM (DMSO) | 341.00 € |
Estimated delivery in United States, on Tuesday 6 May 2025
CARM1-IN-3
CAS:912970-67-3
CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting …
Formula:
C24H32N4O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
408.54
Ref: TM-T79007
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 6 May 2025
