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DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.

Found 448 products of "DNA Methyltransferase"

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  • HLCL-61 hydrochloride
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    HLCL-61 hydrochloride

    CAS:
    HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
    Formula:C23H24N2O·ClH
    Purity:99.88% - 99.95%
    Color and Shape:Solid
    Molecular weight:380.91

    Ref: TM-T6857

  • CM-272
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    CM-272

    CAS:
    CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
    Formula:C28H38N4O3
    Purity:97.83%
    Color and Shape:Solid
    Molecular weight:478.63

    Ref: TM-T7194

  • OICR-9429
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    OICR-9429

    CAS:
    <p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>
    Formula:C29H32F3N5O3
    Purity:97.07% - 99.93%
    Color and Shape:Solid
    Molecular weight:555.59

    Ref: TM-T6916

  • SETDB1-TTD-IN-1
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    SETDB1-TTD-IN-1

    CAS:
    SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.
    Formula:C28H31N5O2
    Purity:98.26% - 99.96%
    Color and Shape:Solid
    Molecular weight:469.58

    Ref: TM-T9742

  • EPZ015666
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    EPZ015666

    CAS:
    EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.
    Formula:C20H25N5O3
    Purity:98% - 99.64%
    Color and Shape:Solid
    Molecular weight:383.44

    Ref: TM-T6076

  • GSK126
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    GSK126

    CAS:
    <p>GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).</p>
    Formula:C31H38N6O2
    Purity:98% - 99.67%
    Color and Shape:Solid
    Molecular weight:526.67

    Ref: TM-T2079

  • SGC707
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    SGC707

    CAS:
    SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
    Formula:C16H18N4O2
    Purity:99.75% - 99.89%
    Color and Shape:Solid
    Molecular weight:298.34

    Ref: TM-T3084

  • GSK503
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    GSK503

    CAS:
    GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.
    Formula:C31H38N6O2
    Purity:98% - 99.89%
    Color and Shape:Solid
    Molecular weight:526.67

    Ref: TM-T1775

  • MIV-6R
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    MIV-6R

    CAS:
    <p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>
    Formula:C27H35N3O
    Purity:99.81% - 99.88%
    Color and Shape:Solid
    Molecular weight:417.59

    Ref: TM-T24472

  • BI-9321 trihydrochloride
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    BI-9321 trihydrochloride

    CAS:
    BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.
    Formula:C22H24Cl3FN4
    Purity:99.12% - 99.34%
    Color and Shape:Solid
    Molecular weight:469.81

    Ref: TM-T10538L

  • CBHcy
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    CBHcy

    CAS:
    <p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>
    Formula:C9H17NO4S
    Purity:>99.99% - >99.99%
    Color and Shape:Solid
    Molecular weight:235.3

    Ref: TM-T25210

  • (S)-HH2853
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    (S)-HH2853

    CAS:
    (S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.
    Formula:C31H36F3N7O3
    Purity:97.18% - 99.74%
    Color and Shape:Solid
    Molecular weight:611.66

    Ref: TM-T73115

  • MS023 dihydrochloride
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    MS023 dihydrochloride

    CAS:
    MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.
    Formula:C17H27Cl2N3O
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:360.32

    Ref: TM-T61338

  • TNG-462
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    TNG-462

    CAS:
    TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).
    Formula:C28H36N6O2S
    Purity:98.7%
    Color and Shape:Solid
    Molecular weight:520.69

    Ref: TM-T79873

  • MRK-740
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    MRK-740

    CAS:
    <p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>
    Formula:C25H32N6O3
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:464.56

    Ref: TM-T62957

  • PFI-2
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    PFI-2

    CAS:
    <p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>
    Formula:C23H25F4N3O3S
    Purity:99.38%
    Color and Shape:Solid
    Molecular weight:499.52

    Ref: TM-T1987

  • GSK2807 Trifluoroacetate
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    GSK2807 Trifluoroacetate

    CAS:
    <p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>
    Formula:C21H33F3N8O7
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:566.53

    Ref: TM-T11486

  • TETi76
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    TETi76

    CAS:
    TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.
    Formula:C10H16O5
    Color and Shape:Solid
    Molecular weight:216.23

    Ref: TM-T200365

  • Acedapsone
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    Acedapsone

    CAS:
    Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.
    Formula:C16H16N2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:332.37

    Ref: TM-T26549

  • Tazemetostat trihydrochloride
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    Tazemetostat trihydrochloride

    CAS:
    Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.
    Formula:C34H47Cl3N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:682.12

    Ref: TM-T15240