DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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UNC8153 TFA
CAS:2929304-61-8
UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and …
Formula:
C35H38F3N5O7
Purity:
96.44%
Color and Shape:
Liquid
Molecular weight:
697.7
Ref: TM-T83867
| 1mg | 78.00 € | ||
| 5mg | 216.00 € | ||
| 10mg | 352.00 € | ||
| 25mg | 579.00 € | ||
| 50mg | 820.00 € |
Estimated delivery in United States, on Thursday 17 Apr 2025
BBDDL2059
CAS:2691174-27-1
BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against …
Formula:
C27H36N4O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
512.66
Ref: TM-T79200
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Thursday 17 Apr 2025
Antitumor agent-101
CAS:2848632-52-8
Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of …
Formula:
C26H38N6O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
482.62
Ref: TM-T79249
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Thursday 17 Apr 2025
CARM1-IN-3
CAS:912970-67-3
CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting …
Formula:
C24H32N4O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
408.54
Ref: TM-T79007
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 17 Apr 2025
AMI-408
CAS:78866-14-5
AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia …
Formula:
C20H13Cl2N6NaO5S
Color and Shape:
Liquid
Molecular weight:
543.32
Ref: TM-T200391
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 15 May 2025
EZM0414
CAS:2411748-50-8
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM …
Formula:
C22H29FN4O2
Purity:
98.9%
Color and Shape:
Liquid
Molecular weight:
400.49
Ref: TM-T9969
| 1mg | 260.00 € | ||
| 5mg | 642.00 € | ||
| 10mg | 909.00 € | ||
| 25mg | 1,364.00 € | ||
| 50mg | 1,821.00 € | ||
| 100mg | 2,460.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
W4275
CAS:3051650-00-8
W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of …
Formula:
C25H36N6O3
Color and Shape:
Liquid
Molecular weight:
468.59
Ref: TM-T200598
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 15 May 2025
AMG-193
CAS:2790567-82-5
AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of …
Formula:
C22H19F3N4O3
Color and Shape:
Liquid
Molecular weight:
444.41
Ref: TM-T85645
| 1mg | 182.00 € | ||
| 5mg | 451.00 € | ||
| 10mg | 646.00 € | ||
| 25mg | 1,008.00 € | ||
| 50mg | 1,391.00 € | ||
| 100mg | 1,839.00 € | ||
| 1mL*10mM (DMSO) | 578.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
PRMT5-IN-1
CAS:2366149-83-7
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for …
Formula:
C19H19ClN4O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
418.83
Ref: TM-T12541
| 25mg | 8,881.00 € | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Thursday 15 May 2025
GSK3368715
CAS:1629013-22-4
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases …
Formula:
C20H38N4O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
366.54
Ref: TM-T11500
| 25mg | 2,523.00 € | ||
| 50mg | 3,348.00 € | ||
| 100mg | 4,583.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
ORIC-944
CAS:2369769-29-7
ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study …
Formula:
C26H25FN6O
Color and Shape:
Liquid
Molecular weight:
456.52
Ref: TM-T87073
| 1mg | To inquire | ||
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Thursday 15 May 2025
PF-06726304 acetate
CAS:2080306-28-9
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
Formula:
C24H25Cl2N3O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
506.38
Ref: TM-T12428
| 10mg | 513.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
GSK3368715 3HCl
CAS:2227587-26-8
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, …
Formula:
C20H41Cl3N4O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
475.92
Ref: TM-T22342
| 25mg | 2,515.00 € | ||
| 50mg | 3,348.00 € | ||
| 100mg | 4,583.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
LLY-283
CAS:2040291-27-6
LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.
Formula:
C17H18N4O4
Purity:
98.79%
Color and Shape:
Solid
Molecular weight:
342.35
Ref: TM-T15767
| 1mg | 40.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
GSK3368715 dihydrochloride
CAS:1628925-77-8
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study …
Formula:
C20H40Cl2N4O2
Purity:
99.66% - 99.66%
Color and Shape:
Solid
Molecular weight:
439.46
Ref: TM-T11500L
| 1mg | 61.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
Dot1L-IN-1
CAS:2088518-50-5
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L …
Formula:
C32H36ClN9O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
646.21
Ref: TM-T11081
| 25mg | 2,523.00 € | ||
| 50mg | 3,346.00 € | ||
| 100mg | 4,580.00 € |
Estimated delivery in United States, on Thursday 15 May 2025
HLCL-61
CAS:586395-74-6
HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).
Formula:
C23H24N2O
Molecular weight:
344.45
Ref: TM-T200932
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 15 May 2025
BRD0639
CAS:2760881-74-9
BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.
Formula:
C21H22ClN5O4S
Purity:
99.85%
Color and Shape:
Solid
Molecular weight:
475.95
Ref: TM-T9329
| 1mg | 56.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 188.00 € | ||
| 25mg | 392.00 € | ||
| 50mg | 534.00 € | ||
| 100mg | 748.00 € | ||
| 1mL*10mM (DMSO) | 131.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
PF-06821497
CAS:1844849-10-0
PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.Cost-effective and quality-assured.
Formula:
C22H24Cl2N2O5
Purity:
97.88%
Color and Shape:
Solid
Molecular weight:
467.34
Ref: TM-T12430
| 1mg | 94.00 € | ||
| 5mg | 223.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 523.00 € | ||
| 50mg | 732.00 € | ||
| 100mg | 918.00 € | ||
| 1mL*10mM (DMSO) | 207.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
Sinefungin
CAS:58944-73-3
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral
Formula:
C15H23N7O5
Purity:
98.12%
Color and Shape:
Solid
Molecular weight:
381.39
Ref: TM-T16886
| 1mg | 124.00 € | ||
| 5mg | 291.00 € | ||
| 10mg | 462.00 € |
Estimated delivery in United States, on Thursday 29 May 2025
