DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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GSK3368715 3HCl
CAS:2227587-26-8
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, …
Formula:
C20H41Cl3N4O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
475.92
Ref: TM-T22342
| 25mg | 2,515.00 € | ||
| 50mg | 3,348.00 € | ||
| 100mg | 4,583.00 € |
Estimated delivery in United States, on Thursday 6 Mar 2025
EZM0414
CAS:2411748-50-8
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM …
Formula:
C22H29FN4O2
Purity:
98.9%
Color and Shape:
Liquid
Molecular weight:
400.49
Ref: TM-T9969
| 1mg | 260.00 € | ||
| 5mg | 642.00 € | ||
| 10mg | 909.00 € | ||
| 25mg | 1,364.00 € | ||
| 50mg | 1,821.00 € | ||
| 100mg | 2,460.00 € |
Estimated delivery in United States, on Thursday 6 Mar 2025
PF-06726304 acetate
CAS:2080306-28-9
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
Formula:
C24H25Cl2N3O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
506.38
Ref: TM-T12428
| 10mg | 513.00 € |
Estimated delivery in United States, on Thursday 6 Mar 2025
LLY-283
CAS:2040291-27-6
LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.
Formula:
C17H18N4O4
Purity:
98.79%
Color and Shape:
Solid
Molecular weight:
342.35
Ref: TM-T15767
| 1mg | 40.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Thursday 6 Mar 2025
PRMT5-IN-1
CAS:2366149-83-7
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for …
Formula:
C19H19ClN4O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
418.83
Ref: TM-T12541
| 25mg | 8,881.00 € | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Thursday 6 Mar 2025
Sinefungin
CAS:58944-73-3
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral
Formula:
C15H23N7O5
Purity:
98.12%
Color and Shape:
Solid
Molecular weight:
381.39
Ref: TM-T16886
| 1mg | 124.00 € | ||
| 5mg | 291.00 € | ||
| 10mg | 462.00 € | ||
| 25mg | 984.00 € | ||
| 50mg | 1,726.00 € | ||
| 100mg | 3,036.00 € |
Estimated delivery in United States, on Thursday 20 Mar 2025
BRD0639
CAS:2760881-74-9
BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.
Formula:
C21H22ClN5O4S
Purity:
99.85%
Color and Shape:
Solid
Molecular weight:
475.95
Ref: TM-T9329
| 1mg | 56.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 188.00 € | ||
| 25mg | 392.00 € | ||
| 50mg | 534.00 € | ||
| 100mg | 748.00 € | ||
| 1mL*10mM (DMSO) | 131.00 € |
Estimated delivery in United States, on Thursday 20 Mar 2025
PF-06821497
CAS:1844849-10-0
PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.Cost-effective and quality-assured.
Formula:
C22H24Cl2N2O5
Purity:
97.88%
Color and Shape:
Solid
Molecular weight:
467.34
Ref: TM-T12430
| 1mg | 94.00 € | ||
| 5mg | 223.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 523.00 € | ||
| 50mg | 732.00 € | ||
| 100mg | 918.00 € | ||
| 1mL*10mM (DMSO) | 207.00 € |
Estimated delivery in United States, on Thursday 20 Mar 2025
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide
CAS:2238820-26-1
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and selective Enhancer of Zeste Homolog 2 (EZH2) inhibitor with IC50 …
Formula:
C32H38N4O4
Purity:
99.03%
Color and Shape:
Soild
Molecular weight:
542.67
Ref: TM-T60194
| 1mg | Discontinued | Request information | |
| 2mg | Discontinued | Request information | |
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information | |
| 500mg | Discontinued | Request information |
EZH2-IN-2
CAS:2238821-31-1
EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM.
Formula:
C36H46N6O3
Purity:
98.23%
Color and Shape:
Solid
Molecular weight:
610.79
Ref: TM-T9700
| 1mg | Discontinued | Request information | |
| 2mg | Discontinued | Request information | |
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information | |
| 500mg | Discontinued | Request information | |
| 1ml*10 (DMSO) | Discontinued | Request information |
CMP 10
CAS:2565705-02-2
CMP 10 (Dot1L-IN-4) is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.
Formula:
C28H27ClF2N8O5S
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
661.08
Ref: TM-T8881
| 1mg | Discontinued | Request information | |
| 2mg | Discontinued | Request information | |
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information | |
| 1ml*10 (DMSO) | Discontinued | Request information |
