Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 88 products of "Sirtuin"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
SIRT-IN-2
CAS:<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formula:C11H15N2O5Purity:98.82% - 99.58%Color and Shape:SolidMolecular weight:255.25Resveratrol
CAS:<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Formula:C14H12O3Purity:99.82% - 99.96%Color and Shape:Off-White To Tan PowderMolecular weight:228.24MC3482
CAS:<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Formula:C33H38N4O8Purity:98% - 99.90%Color and Shape:SoildMolecular weight:618.68MIND4-19
CAS:<p>MIND4-19 is an inhibitor of SIRT2 with antitumor activity.</p>Formula:C22H19N3OSPurity:99.9%Color and Shape:SolidMolecular weight:373.47SIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Formula:C55H91N9O15SColor and Shape:SolidMolecular weight:1150.43SIRT5 inhibitor 8
CAS:<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Formula:C22H25ClN8O2SPurity:99.56%Color and Shape:SolidMolecular weight:501Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formula:C34H46N6O6SPurity:99.52%Color and Shape:SolidMolecular weight:666.83Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Formula:C20H15N3O2SPurity:99.32%Color and Shape:SolidMolecular weight:361.42WAY-323061
CAS:<p>WAY-323061 is a SIRT2 inhibitor.</p>Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53BML-278
CAS:<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formula:C24H25NO4Purity:99.53%Color and Shape:SolidMolecular weight:391.46SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Formula:C24H15N3O2SColor and Shape:SolidMolecular weight:409.46SJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Color and Shape:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formula:C14H16N2OPurity:99.58%Color and Shape:SolidMolecular weight:228.29Sirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formula:C19H15N3O2SPurity:99.67%Color and Shape:SolidMolecular weight:349.41SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5SIRT-IN-5
<p>SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.</p>Color and Shape:Odour SolidZ26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formula:C17H15FN2OPurity:99.63%Color and Shape:SolidMolecular weight:282.31SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Purity:98%Color and Shape:Odour SolidSirt1/2-IN-4
<p>Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (</p>Formula:C21H20N4O3S2Purity:98%Color and Shape:SolidMolecular weight:440.54
![Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT60001.webp&w=3840&q=75)
