Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 86 products of "Sirtuin"
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MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formula:C33H38N4O8Purity:98% - 99.90%Color and Shape:SoildMolecular weight:618.68Ref: TM-T11962
1mg50.00€2mg71.00€5mg105.00€10mg170.00€25mg268.00€50mg423.00€100mg685.00€500mg1,378.00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-
Formula:C11H15N2O5Purity:98.82% - 99.58%Color and Shape:SolidMolecular weight:255.25SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49Ref: TM-T12919
1mg92.00€5mg215.00€10mg344.00€25mg587.00€50mg803.00€100mg1,099.00€200mg1,468.00€1mL*10mM (DMSO)236.00€Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Formula:C14H12O3Purity:99.82% - 99.96%Color and Shape:Off-White To Tan PowderMolecular weight:228.24Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.67%Color and Shape:SolidMolecular weight:349.41Et-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Formula:C34H46N6O6SPurity:99.52%Color and Shape:SolidMolecular weight:666.83WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Color and Shape:Odour SolidZ26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Formula:C17H15FN2OPurity:99.54%Color and Shape:SolidMolecular weight:282.31Ref: TM-T77653
1mg34.00€2mg77.00€5mg77.00€10mg105.00€25mg187.00€50mg269.00€100mg398.00€500mg1,333.00€Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formula:C20H15N3O2SPurity:99.32%Color and Shape:SolidMolecular weight:361.42SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.Formula:C24H15N3O2SColor and Shape:SolidMolecular weight:409.46SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Formula:C55H91N9O15SColor and Shape:SolidMolecular weight:1150.43SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formula:C14H16N2OPurity:99.58%Color and Shape:SolidMolecular weight:228.29Ref: TM-T9648
1mg92.00€5mg192.00€10mg295.00€25mg505.00€50mg708.00€100mg964.00€200mg1,288.00€1mL*10mM (DMSO)195.00€MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formula:C22H19N3OSPurity:99.9%Color and Shape:SolidMolecular weight:373.47SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Purity:98%Color and Shape:Odour SolidSIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurity:99.56%Color and Shape:SolidMolecular weight:501Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Formula:C21H20N4O3S2Purity:98%Color and Shape:SolidMolecular weight:440.54SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurity:98.68%Color and Shape:SolidMolecular weight:561.06ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formula:C26H29I2NO3Purity:99.23%Color and Shape:SolidMolecular weight:657.32SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:285.73Ref: TM-T39233
1mg96.00€5mg235.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)259.00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg39.00€2mg51.00€5mg70.00€10mg88.00€25mg140.00€50mg226.00€100mg376.00€1mL*10mM (DMSO)73.00€Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purity:99.71% - 99.98%Color and Shape:White PowderMolecular weight:440.40SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:99.52% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg39.00€2mg50.00€5mg79.00€10mg107.00€25mg197.00€50mg311.00€100mg505.00€1mL*10mM (DMSO)90.00€Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Formula:C9H8O2Purity:98.46%Color and Shape:Leaflets Room Temperature (Ntp 1992)Molecular weight:148.16Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.483-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purity:99.16% - >99.99%Color and Shape:SolidMolecular weight:146.15Ref: TM-T4108
2mg39.00€5mg52.00€10mg93.00€25mg166.00€50mg248.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)52.00€Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purity:98.06% - 99.98%Color and Shape:SolidMolecular weight:514.65AGK2
CAS:AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Formula:C26H22N2O2Purity:97.09% - 99.55%Color and Shape:SolidMolecular weight:394.47B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purity:99.66%Color and Shape:SolidMolecular weight:396.83E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Formula:C21H21N3O3Purity:98.45%Color and Shape:SolidMolecular weight:363.41Ref: TM-T9106
1mg34.00€5mg70.00€10mg99.00€25mg195.00€50mg311.00€100mg449.00€500mg888.00€1mL*10mM (DMSO)94.00€Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purity:98% - 99.36%Color and Shape:SolidMolecular weight:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:98.31%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg38.00€5mg77.00€10mg110.00€25mg215.00€50mg306.00€100mg429.00€200mg600.00€1mL*10mM (DMSO)95.00€Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.75SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurity:99.16%Color and Shape:SolidMolecular weight:581.85Ref: TM-T3447
1mg54.00€2mg73.00€5mg92.00€10mg117.00€25mg215.00€50mg360.00€100mg537.00€1mL*10mM (DMSO)117.00€SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurity:98.58%Color and Shape:SolidMolecular weight:542.48Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurity:98.53% - 99.94%Color and Shape:SolidMolecular weight:248.71Ref: TM-T6111
5mg48.00€10mg54.00€25mg87.00€50mg133.00€100mg222.00€200mg330.00€500mg535.00€1mL*10mM (DMSO)50.00€Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
Formula:C13H13ClN2OPurity:99.86%Color and Shape:SolidMolecular weight:248.71Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Formula:C16H18O9Purity:98.97% - ≥95%Color and Shape:SolidMolecular weight:354.31AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:98.89% - >99.99%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg38.00€5mg57.00€10mg93.00€25mg170.00€50mg289.00€100mg507.00€200mg655.00€500mg1,018.00€1mL*10mM (DMSO)63.00€Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.8%Color and Shape:SolidMolecular weight:248.71Ref: TM-T15263
1mg106.00€2mg159.00€5mg259.00€10mg376.00€25mg630.00€50mg880.00€100mg1,169.00€1mL*10mM (DMSO)284.00€Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
Formula:C44H70O16Purity:99.77%Color and Shape:SolidMolecular weight:855.02SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Formula:C26H24N6O2S2Purity:98.34% - 99.82%Color and Shape:SolidMolecular weight:516.64Ref: TM-T6679
1g1,558.00€1mg43.00€5mg93.00€10mg124.00€25mg219.00€50mg358.00€100mg533.00€200mg763.00€500mg1,161.00€
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