Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 88 products of "Sirtuin"
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Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formula:C11H15N2O5Purity:98.82% - 99.58%Color and Shape:SolidMolecular weight:255.25Resveratrol
CAS:<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Formula:C14H12O3Purity:99.82% - 99.96%Color and Shape:Off-White To Tan PowderMolecular weight:228.24MC3482
CAS:<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Formula:C33H38N4O8Purity:98% - 99.90%Color and Shape:SoildMolecular weight:618.68SIRT-IN-2
CAS:<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49SIRT5 inhibitor 9
CAS:<p>SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.</p>Formula:C24H29ClN8O4SPurity:98.68%Color and Shape:SolidMolecular weight:561.06Z26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formula:C17H15FN2OPurity:99.63%Color and Shape:SolidMolecular weight:282.31Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formula:C34H46N6O6SPurity:99.52%Color and Shape:SolidMolecular weight:666.83SIRT-IN-5
<p>SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.</p>Color and Shape:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formula:C14H16N2OPurity:99.58%Color and Shape:SolidMolecular weight:228.29SIRT5 inhibitor 8
CAS:<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Formula:C22H25ClN8O2SPurity:99.56%Color and Shape:SolidMolecular weight:501SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Purity:98%Color and Shape:Odour SolidSIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Formula:C55H91N9O15SColor and Shape:SolidMolecular weight:1150.43BML-278
CAS:<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formula:C24H25NO4Purity:99.53%Color and Shape:SolidMolecular weight:391.46SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5SJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Color and Shape:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Formula:C20H15N3O2SPurity:99.32%Color and Shape:SolidMolecular weight:361.42SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Formula:C24H15N3O2SColor and Shape:SolidMolecular weight:409.46MIND4-19
CAS:<p>MIND4-19 is an inhibitor of SIRT2 with antitumor activity.</p>Formula:C22H19N3OSPurity:99.9%Color and Shape:SolidMolecular weight:373.47Sirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formula:C19H15N3O2SPurity:99.67%Color and Shape:SolidMolecular weight:349.41Sirt1/2-IN-4
<p>Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (</p>Formula:C21H20N4O3S2Purity:98%Color and Shape:SolidMolecular weight:440.54WAY-323061
CAS:<p>WAY-323061 is a SIRT2 inhibitor.</p>Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53SIRT5 inhibitor 3
CAS:<p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35ADTL-SA1215
CAS:<p>ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.</p>Formula:C26H29I2NO3Purity:99.23%Color and Shape:SolidMolecular weight:657.32Thiomyristoyl
CAS:<p>Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.</p>Formula:C34H51N3O3SPurity:99.16%Color and Shape:SolidMolecular weight:581.85Selisistat S-enantiomer
CAS:<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Formula:C13H13ClN2OPurity:99.86%Color and Shape:SolidMolecular weight:248.71Suramin Sodium Salt
CAS:<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15CAY10602
CAS:<p>CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.</p>Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44Nicotinamide riboside chloride
CAS:<p>NR, also SRT647, is a B3 vitamin form; precursor to NAD+.</p>Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7AK-1
CAS:<p>AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.</p>Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45E1231
CAS:<p>E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.</p>Formula:C21H21N3O3Purity:98.45%Color and Shape:SolidMolecular weight:363.41YK-3-237
CAS:<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Formula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Scopolin
CAS:<p>Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.</p>Formula:C16H18O9Purity:98.97% - ≥95%Color and Shape:SolidMolecular weight:354.31Agrimol B
CAS:<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.753-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formula:C7H6N4Purity:99.16% - >99.99%Color and Shape:SolidMolecular weight:146.15Tenovin-1
CAS:<p>Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.</p>Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.48Dihydrocoumarin
CAS:<p>Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).</p>Formula:C9H8O2Purity:98.46%Color and Shape:Leaflets Room Temperature (Ntp 1992)Molecular weight:148.16Gardenia yellow
CAS:<p>Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.</p>Formula:C44H64O24Purity:98.24% - 98.82%Color and Shape:Orange Yellow To Reddish Yellow PowderMolecular weight:976.96Tenovin-6
CAS:<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Formula:C25H34N4O2SPurity:97.71% - >99.99%Color and Shape:SolidMolecular weight:454.63Selisistat
CAS:<p>Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).</p>Formula:C13H13ClN2OPurity:98.53% - 99.94%Color and Shape:SolidMolecular weight:248.71SRT1720 hydrochloride
CAS:<p>SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).</p>Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22SRT 1720 dihydrochloride
CAS:<p>SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).</p>Formula:C25H25Cl2N7OSPurity:98.58%Color and Shape:SolidMolecular weight:542.48Ginkgolide C
CAS:<p>Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.</p>Formula:C20H24O11Purity:99.71% - 99.98%Color and Shape:White PowderMolecular weight:440.4SirReal2
CAS:<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Formula:C22H20N4OS2Purity:98.96% - 99.75%Color and Shape:SolidMolecular weight:420.55Ganoderic acid D
CAS:<p>Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.</p>Formula:C30H42O7Purity:98.06% - 99.98%Color and Shape:SolidMolecular weight:514.65AGK2
CAS:<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27Salermide
CAS:<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Formula:C26H22N2O2Purity:97.09% - 99.55%Color and Shape:SolidMolecular weight:394.47Inauhzin
CAS:<p>Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).</p>Formula:C25H19N5OS2Purity:98% - 99.36%Color and Shape:SolidMolecular weight:469.58UBCS039
CAS:<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Formula:C16H13N3Purity:98.31%Color and Shape:SolidMolecular weight:247.29SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Selisistat R-enantiomer
CAS:<p>Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).</p>Formula:C13H13ClN2OPurity:99.8%Color and Shape:SolidMolecular weight:248.71
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