Endocrinology/Hormones
Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.
Subcategories of "Endocrinology/Hormones"
- Androgen Receptor(229 products)
- Annexin A(16 products)
- Aromatase(23 products)
- Estrogen/progestogen Receptor(66 products)
- GPR(1 products)
- Glucocorticoid Receptor(165 products)
- LHRH(2 products)
- Opioid Receptor(327 products)
- Prostaglandin Receptor(122 products)
- RAAS(89 products)
- Reductase(51 products)
- Somatostatin(57 products)
- Thyroid hormone receptor(THR)(33 products)
- Vasopressin Receptor(48 products)
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Found 3420 products of "Endocrinology/Hormones"
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Nurr1 agonist 8
CAS:Nurr1 agonist 8 is a low-affinity Nurr1 agonist that can be used to study neurological diseases such as Parkinson's.Formula:C14H10Cl2O3Purity:99.79%Color and Shape:SolidMolecular weight:297.13UFP-512
CAS:UFP-512 is a selective delta-opioid (DOP) receptor agonist.Formula:C31H33N5O5Purity:98%Color and Shape:SolidMolecular weight:555.62YXG-158
CAS:YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1Formula:C30H36FN3OPurity:98%Color and Shape:SolidMolecular weight:473.62Triiodothyronine Sulfate
CAS:Triiodothyronine sulfate: Hypothyroidism prodrug, metabolizes into active thyroid hormone T3, binds and activates TRβ1.Formula:C15H11I3NNaO7SPurity:98%Color and Shape:SolidMolecular weight:753.02GPR40 Agonist 2
CAS:GPR40 Agonist 2 is a GPR40 agonist. It can be used in the research of diabetes.Formula:C24H30O3Purity:98%Color and Shape:SolidMolecular weight:366.49ES 8891
CAS:ES 8891 is an inhibitor of renin.Formula:C42H60N6O6SPurity:98%Color and Shape:SolidMolecular weight:777.03RTI-13951-33
CAS:RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).Formula:C28H33N3O3Purity:98%Color and Shape:SolidMolecular weight:459.58Estrogen receptor antagonist 5
CAS:Compound 165: Potent estrogen receptor antagonist; useful for metastatic disease research.Formula:C25H31F3N2O3Color and Shape:SolidMolecular weight:464.52Androgen receptor antagonist 5
CAS:AR antagonist 5 blocks AR (IC50: 6.17 μM), hinders LNCaP cell growth, and has anti-tumor effects in mouse models.Formula:C21H15F4N5O3SColor and Shape:SolidMolecular weight:493.43MB-07344
CAS:MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC).Formula:C19H25O5PPurity:99.32%Color and Shape:SolidMolecular weight:364.37Icalcaprant
CAS:Icalcaprant is a kappa-opioid receptor antagonist [1].Formula:C23H26N4O3Purity:98%Color and Shape:SolidMolecular weight:406.48DPI-3290
CAS:DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potentFormula:C30H34FN3O2Purity:98%Color and Shape:SolidMolecular weight:487.61SQ 32970
CAS:SQ 32970 is a potent Endothia aspartic proteinase inhibitor.Formula:C33H51N5O4SColor and Shape:SolidMolecular weight:613.85DS08210767
CAS:DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.Formula:C31H39N5O2Purity:98.79%Color and Shape:SolidMolecular weight:513.67Giredestrant tartrate
CAS:Giredestrant tartrate: a new oral, selective non-steroidal ER antagonist, inhibits ER-mediated gene activation and degrades ER protein, treating tumors.Formula:C31H37F5N4O7Purity:97.01%Color and Shape:SolidMolecular weight:672.64GW-803430
CAS:GW-803430: potent MCH R1 antagonist, pIC50=9.3, orally effective against obesity in animals.Formula:C25H24ClN3O3SPurity:98.07% - 98.97%Color and Shape:SolidMolecular weight:481.99MB-07811
CAS:MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity.Formula:C28H32ClO5PPurity:99.74% - 99.94%Color and Shape:SolidMolecular weight:514.98Ranirestat
CAS:Ranirestat (AS-3201) is an AR inhibitor with neuroprotective properties that improves peripheral nerve dysfunction in rats with advanced diabetic polyneuropathyFormula:C17H11BrFN3O4Purity:96.10% - 99.44%Color and Shape:SolidMolecular weight:420.19Rovatirelin
CAS:Rovatirelin (S-0373) is a TRH analog that improves motor dysfunction in a rat model of cytosine arabinoside-induced spinal cerebellar degeneration.Formula:C16H22N4O4SPurity:99.59%Color and Shape:SolidMolecular weight:366.43Baxdrostat
CAS:Baxdrostat is an aldosterone synthase inhibitor.Formula:C22H25N3O2Purity:99.8%Color and Shape:SolidMolecular weight:363.45Ref: TM-T61373
1mg71.00€5mg152.00€10mg236.00€25mg393.00€50mg550.00€100mg707.00€200mg982.00€1mL*10mM (DMSO)167.00€CO23
CAS:CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.Formula:C19H18I2N2O4Purity:98.08%Color and Shape:SolidMolecular weight:592.17AMG 837 calcium hydrate
CAS:AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.Formula:C52H44CaF6O8Purity:98.07%Color and Shape:SolidMolecular weight:950.97LX1
CAS:LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Formula:C22H15F6NO2Color and Shape:SolidMolecular weight:439.35AR ligand-44
CAS:AR ligand-44 is an androgen receptor (androgen receptor) ligand that can be utilized in the synthesis of PROTACs such as [ARD-2051].Formula:C23H24ClN3O2Color and Shape:SolidMolecular weight:409.91FSH receptor antagonist 1
CAS:FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.Formula:C33H32N2O2Color and Shape:SolidMolecular weight:488.619AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Formula:C24H20N2O4Color and Shape:SolidMolecular weight:400.43C108297
CAS:C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.Formula:C30H36FN3O4SPurity:98%Color and Shape:SolidMolecular weight:553.69ERRα antagonist-2
CAS:ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.Formula:C19H16N2O6SPurity:99.26%Color and Shape:SolidMolecular weight:400.41LNS8801
CAS:LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.Formula:C21H18BrNO3Color and Shape:SolidMolecular weight:412.277Dazucorilant
CAS:Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.Formula:C29H22F4N4O3SColor and Shape:SolidMolecular weight:582.57A4B17
A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.Formula:C14H7F4NSColor and Shape:SolidMolecular weight:297.27ER degrader 10
CAS:ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.Formula:C28H29F2NO3SColor and Shape:SolidMolecular weight:497.597GPR81 agonist 2
CAS:GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.Formula:C26H27ClN6O5S2Color and Shape:SolidMolecular weight:603.11MB-07344 sodium
"MB-07344 sodium is a TR-β agonist with a 2.17 nM Ki, boosts Atorvastatin's cholesterol-lowering effects in various animals."Formula:C19H25NaO5PPurity:98%Color and Shape:SolidMolecular weight:387.36EN171
CAS:EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.Formula:C17H22N2OColor and Shape:SolidMolecular weight:270.37KF-19418
CAS:KF-19418 is a follicle stimulant that directly activates follicles in vitro and promotes hair growth in vivo.Formula:C21H14N4OColor and Shape:SolidMolecular weight:338.36Allyphenyline oxalate
CAS:The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.Formula:C16H20N2O5Color and Shape:SolidMolecular weight:320.34BU09059
CAS:BU09059 is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR).Formula:C28H37N3O5Purity:98%Color and Shape:SolidMolecular weight:495.61ACT 178882
CAS:ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM).Formula:C33H38Cl3N3O4Purity:98%Color and Shape:SolidMolecular weight:647.03GLPG0492 (R enantiomer)
CAS:GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.Formula:C19H14F3N3O3Color and Shape:SolidMolecular weight:389.33AVE 0991
CAS:AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.Formula:C29H32N4O5S2Purity:99.73%Color and Shape:SolidMolecular weight:580.72AP5 sodium
CAS:AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.Formula:C28H27FNNaO4Color and Shape:SolidMolecular weight:483.515JDTic Dihydrochloride
CAS:JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.Formula:C28H41Cl2N3O3Purity:98%Color and Shape:SolidMolecular weight:538.55ADX61623
CAS:ADX61623 is an effective negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR). It also exhibits activity on the luteinizing hormone receptor (LH-R) but is inactive on the thyroid-stimulating hormone (TSH) receptor. ADX61623 can be utilized in research on estrogen-dependent diseases.Formula:C19H20N2O3Color and Shape:SolidMolecular weight:324.37ERα degrader 11
CAS:ERα degrader11 (compound B16) is a selective estrogen receptor degrader designed for use as a probe in examining the ER status within ER-positive breast cancer cells.Formula:C28H27F3N2O3Color and Shape:SolidMolecular weight:496.52Estrone acetate
CAS:Estrone acetate (Hogival) is an estrogen derivative and an activator of estrogen receptors (ER). This compound can enhance breast development, stimulate the secretion of pituitary prolactin, and induce both the proliferation and activation of lactotrophs, evidenced by the reduction in prolactin storage granule size and the increase in the volume density of the rough endoplasmic reticulum and Golgi apparatus. Estrone acetate holds potential for endocrinological research and for investigating the mechanisms by which estrogen influences pituitary function, prolactin regulation, and breast tumor models.Formula:C20H24O3Color and Shape:SolidMolecular weight:312.403ORIC-101
CAS:ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.Formula:C34H47NO2Purity:98%Color and Shape:SolidMolecular weight:501.74Pentomone
CAS:Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formula:C24H26O5Color and Shape:SolidMolecular weight:394.46Estrogen receptor antagonist 4
CAS:Estrogen receptor antagonist 4 blocks ER, impacting cell growth and cancer research potential.Formula:C23H29BF4N4O2Color and Shape:SolidMolecular weight:480.3122-Hydroxy mifepristone
CAS:22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.Formula:C29H35NO3Color and Shape:SolidMolecular weight:445.59Androstatrione
CAS:Androstatrione is an androgenic compound.Formula:C19H26O3Color and Shape:SolidMolecular weight:302.41Metahexestrol
CAS:Metahexestrol is an inhibitor of the estrogen receptor (E2R) with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cell line with an ED50 of 1.0 μM. Additionally, Metahexestrol shows inhibitory activity in estrogen receptor-negative MDA-MB-231 cell lines, and its antiproliferative effect is not reversed by estrogen, suggesting that its mechanism may be partially independent of the E2R pathway. Metahexestrol is applicable in research on estrogen-dependent breast cancer.Formula:C18H22O2Color and Shape:SolidMolecular weight:270.366GC 14
CAS:GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.Formula:C26H27NO6Purity:98%Color and Shape:SolidMolecular weight:449.5LIT-001 free base
CAS:LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.Formula:C28H33N7O2SPurity:98%Color and Shape:SolidMolecular weight:531.67Androgen receptor ligand 1
CAS:Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.Formula:C19H16F4N2OColor and Shape:SolidMolecular weight:364.34ErSO-DFP
ErSO-DFP activates a-UPR, targets ERα+ cancer cells with high selectivity, and effectively reduces MCF-7 tumours.Formula:C20H17F5N2O2Color and Shape:SolidMolecular weight:412.35Opioid receptor antagonist 1
CAS:Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.
Formula:C24H29ClF3NO4Color and Shape:SolidMolecular weight:487.94Galaxolide
CAS:Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).Formula:C18H26OColor and Shape:SolidMolecular weight:258.40MTI013
MTI013 is a selective inhibitor of SARS-CoV-2 nsp14 Mtase (IC50: 2.98 µM) and an antiviral agent (IC50: 10.33 µM in HCoV-229E infected Huh7 cells). Additionally, MTI013 demonstrates synergistic antiviral effects when used in conjunction with the RdRp inhibitor SHEN26.Formula:C24H26N6O4SColor and Shape:SolidMolecular weight:494.57OT-R agonist 1 TFA
CAS:OT-R agonist 1 TFA (compound 5) is an oxytocin receptor (OT-R) agonist with an EC50 value of 0.39 nM. It exhibits V1A antagonist activity, with an EC50 value of 2432 nM, and can be utilized in studies related to central nervous system diseases.Formula:C37H40F3N7O7SColor and Shape:SolidMolecular weight:783.82CH5447240
CAS:CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.Formula:C26H39N5O4SPurity:98%Color and Shape:SolidMolecular weight:517.68ERβ agonist-1
CAS:ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.Formula:C25H36O2Color and Shape:SolidMolecular weight:368.55Emd 52297
CAS:Emd 52297 is an inhibitor of renin.Formula:C39H59N11O7Purity:98%Color and Shape:SolidMolecular weight:793.96ID11916
CAS:ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.Formula:C29H27F3N8O3SColor and Shape:SolidMolecular weight:624.637AR antagonist 11
CAS:AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.Formula:C20H17ClN2OColor and Shape:SolidMolecular weight:336.815(E/Z)-OT-R antagonist 1
CAS:(E/Z)-OT-R antagonist 1 is a mixture of the E/Z configurations of OT-R antagonist 1. This compound is a novel, potent, selective, non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activity with an IC50 of 8 nM.Formula:C28H29N3O4Color and Shape:SolidMolecular weight:471.55Ciprokiren
CAS:Ciprokiren, a renin inhibitor by Roche, halts human renin; IC50: 0.07/0.65 nmol/L. Lowers blood pressure in animals. Preclinical development ceased.Formula:C37H55N5O8SColor and Shape:SolidMolecular weight:729.93Phenethyl 4-ANPP
CAS:Phenethyl 4-ANPP is a MOR (μ-opioid receptor) agonist with a structure similar to known opioids.Formula:C27H32N2Color and Shape:SolidMolecular weight:384.56LEO 134310
CAS:LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.Formula:C34H40N2O8Color and Shape:SolidMolecular weight:604.69Androgen receptor antagonist 13
CAS:Androgen receptor antagonist 13 (compound 8a) is an orally active androgen receptor antagonist with an IC50 of 0.20 μM. It is used in prostate cancer research.Formula:C16H15N3O3SColor and Shape:SolidMolecular weight:329.37EN1441
CAS:EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.Formula:C13H13ClN2O2Color and Shape:SolidMolecular weight:264.708Sob-AM2
CAS:Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).Formula:C21H27NO3Color and Shape:SolidMolecular weight:341.44AKR1C3-IN-5
AKR1C3-IN-5 inhibits AKR1C3, key in prostate/breast cancers, with MCF-7 cell IC50 of 9.6 μM.Formula:C34H44N2O7Color and Shape:SolidMolecular weight:592.72Estrogen receptor antagonist 7
CAS:ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.Formula:C23H17N3O4Color and Shape:SolidMolecular weight:399.4AR antagonist 10
CAS:AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.Formula:C18H17ClN4O3SColor and Shape:SolidMolecular weight:404.871PBPE hydrochloride
CAS:PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.Formula:C19H24ClNOColor and Shape:SolidMolecular weight:317.853Estrogen receptor modulator 11
CAS:Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.Formula:C21H18FNOColor and Shape:SolidMolecular weight:319.372Bromadoline
CAS:Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.Formula:C15H21BrN2OColor and Shape:SolidMolecular weight:325.244Triisopropyl phosphate
CAS:Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.Formula:C9H21O4PColor and Shape:SolidMolecular weight:224.234LXT34
CAS:LXT34 (Example 2) is a GPR120 agonist with anti-inflammatory properties. This compound enhances GLP-1 formation in the gastrointestinal tract and improves insulin resistance in macrophages and pancreatic cells. LXT34 is applicable in studies related to inflammatory conditions, such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.Formula:C18H21NO3SColor and Shape:SolidMolecular weight:331.43KNT-127
CAS:KNT-127 is an agonist of δ-Opioid receptor.Formula:C24H24N2O2Purity:98%Color and Shape:SolidMolecular weight:372.46AP5
CAS:AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.Formula:C28H28FNO4Purity:98%Color and Shape:SolidMolecular weight:461.52Naltrindole 5′-isothiocyanate
CAS:Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.Formula:C27H25N3O3SColor and Shape:SolidMolecular weight:471.571Urotensin-II receptor antagonist-1
CAS:Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).Formula:C25H31Cl2N3OColor and Shape:SolidMolecular weight:460.439THR-β agonist 4
CAS:THR-β agonist 4 is a potent agonist of THR-β.Formula:C16H11Cl2F2N5O6SColor and Shape:SolidMolecular weight:510.26Androgen receptor antagonist 11
CAS:Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.Formula:C20H19F3N4O3SColor and Shape:SolidMolecular weight:452.45U 80215
CAS:U 80215 is an enzyme-competitive inhibitor.Formula:C42H60N8O6SColor and Shape:SolidMolecular weight:805.04Saprisartan potassium
CAS:Saprisartan potassium is an Angiotensin II Type 1 receptor antagonist and antihypertensive agent.Formula:C25H21BrF3KN4O4SColor and Shape:SolidMolecular weight:649.52Novokinin
CAS:Angiotensin AT2 receptor agonistFormula:C39H61N11O7Purity:98%Color and Shape:SolidMolecular weight:795.9721-Deacetoxy deflazacort
CAS:21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.Formula:C23H29NO4Color and Shape:SolidMolecular weight:383.485′-Guanidinonaltrindole
CAS:5′-Guanidinonaltrindole (GNTI) is a selective antagonist of the kappa opioid receptor.Formula:C27H29N5O3Color and Shape:SolidMolecular weight:471.551L162389
CAS:L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.Formula:C31H38N4O4SPurity:99.11% - 99.57%Color and Shape:SolidMolecular weight:562.72BMS-248360
CAS:BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.Formula:C36H45N5O5SPurity:98%Color and Shape:SolidMolecular weight:659.84GDC-0927 Racemate
CAS:GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.Formula:C28H28FNO4Purity:98%Color and Shape:SolidMolecular weight:461.52Erα-IN-1
Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.Formula:C16H11FN2Color and Shape:SolidMolecular weight:250.27BNTX
CAS:BNTX (7-Benzylidenenaltrexone) is a selective δ1-opioid receptor antagonist. It competitively counteracts the antisecretory effects of DPDPE, Deltorphin 2, and DAMGO. BNTX is applicable in research focused on antinociceptive effects.Formula:C27H27NO4Color and Shape:SolidMolecular weight:429.508OSU-ERb-12
CAS:OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].Formula:C15H30B10O2Color and Shape:SolidMolecular weight:350.51GW856464
CAS:GW856464 is an antagonist of MCHR1. It is utilized in research related to cardiovascular diseases and obesity.Formula:C23H20ClN3O3SColor and Shape:SolidMolecular weight:453.94BU72
CAS:BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.Formula:C28H32N2O2Color and Shape:SolidMolecular weight:428.57GSK866
CAS:GSK866 is a selective glucocorticoid receptor agonist (SEGRA).Formula:C23H21Cl2F4N5O3Color and Shape:SolidMolecular weight:562.34
