Endocrinology/Hormones

DPC-AJ1951 TFA is a 14 amino acid peptide, potent PTH/PPR agonist, tested in bone resorption assays.

Piperidylthiambutene hydrochloride is an opioid compound that exhibits analgesic effects in animal models.

Methylpiperidino pyrazole is an ERα inhibitor and can prevent the BPS-induced Rb phosphorylation and cell cycle progression.

Norethynodrel, a synthetic hormone, mimics progesterone, treats uterine bleeding/endometriosis, and is used with mestranol as a contraceptive.

(Glu2)-TRH: Stable TRH analog; reduces TRH's cholinergic action; no thyroliberinase metabolism; neuroprotective with antidepressant, anticonvulsant effects.

Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting

Compound 13, a Nurr1 agonist, exhibits a dissociation constant (Kd) of 1.5 μM and an effective concentration for 50% response (EC50) of 3 μM [1].

TF-505, a steroid 5α-reductase inhibitor, is used potentially for the treatment of benign prostatic hyperplasia.

DBPR116 is a prodrug of BPRMU191 that can penetrate the blood-brain barrier. It significantly enhances the delivery efficiency of drugs targeting the central nervous system. When combined with the antagonist Naltrexone, DBPR116 demonstrates superior safety and analgesic effects compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing promise as a safer opioid analgesic.

NH-3, an orally active THR antagonist with a 55 nM IC50, blocks thyroid hormone binding and cofactor recruitment.

Isomer-Turosteride, a novel 5α-reductase inhibitor, reduces prostate DHT and has anticancer properties without raising T levels.

AT-121 hydrochloride: dual nociception/mu-opioid agonist, Ki 3.67/16.49 nM, safe, non-addictive pain reliever with analgesic effects.

Deacylcortivazol is a potent glucocorticoid that inhibits growth in glucocorticoid-resistant leukemia cells without receptor mediation.

μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.

α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin.

7α-(Thiomethyl)spironolactone is a steroid receptor antagonist and major spironolactone metabolite, steroid metabolism, nuclear receptor, and coronavirus.

PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein.

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II

3,5-Diiodothyroacetic acid is a thyroid hormone analog that has been found to reduce cholesterol concentrations and may be used in the study of hypothyroidism.

PU-WS13 hydrobromide is a GRP94 inhibitor with anti-inflammatory activity and inhibits the proliferation of M2-like macrophages in mouse TNBC tumors.