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Endocrinology/Hormones

Endocrinology/Hormones

Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.

Subcategories of "Endocrinology/Hormones"

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Found 3180 products of "Endocrinology/Hormones"

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  • LY2066948
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    LY2066948

    CAS:
    <p>LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.</p>
    Formula:C30H31NO5S
    Color and Shape:Solid
    Molecular weight:517.64

    Ref: TM-T200177

  • Norbinaltorphimine dihydrochloride
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    Norbinaltorphimine dihydrochloride

    CAS:
    <p>Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.</p>
    Formula:C40H45Cl2N3O6
    Purity:98.17% - 99.88%
    Color and Shape:Solid
    Molecular weight:734.71

    Ref: TM-T12241

  • CCG258747
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    CCG258747

    CAS:
    <p>CCG258747 is a novel, selective inhibitor of the GRK2 subfamily.</p>
    Formula:C28H27FN4O4
    Color and Shape:Solid
    Molecular weight:502.54

    Ref: TM-T63411

  • ERRα antagonist-2
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    ERRα antagonist-2

    CAS:
    <p>ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.</p>
    Formula:C19H16N2O6S
    Purity:99.26%
    Color and Shape:Solid
    Molecular weight:400.41

    Ref: TM-T61923

  • ERβ agonist-1
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    ERβ agonist-1

    CAS:
    <p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>
    Formula:C25H36O2
    Color and Shape:Solid
    Molecular weight:368.55

    Ref: TM-T207458

  • MK-6913
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    MK-6913

    CAS:
    <p>MK-6913 is a potent and selective agonist of estrogen receptor β.</p>
    Formula:C25H27N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.5

    Ref: TM-T13136

  • ID11916
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    ID11916

    CAS:
    <p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>
    Formula:C29H27F3N8O3S
    Color and Shape:Solid
    Molecular weight:624.637

    Ref: TM-T206742

  • AR antagonist 11
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    AR antagonist 11

    CAS:
    <p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>
    Formula:C20H17ClN2O
    Color and Shape:Solid
    Molecular weight:336.815

    Ref: TM-T206875

  • JDTic Dihydrochloride
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    JDTic Dihydrochloride

    CAS:
    JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.
    Formula:C28H41Cl2N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.55

    Ref: TM-T11721L

  • Elacestrant S enantiomer dihydrochloride
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    Elacestrant S enantiomer dihydrochloride

    <p>Elacestrant (RAD1901) dihydrochloride, an oral ERR degrader, has IC50 of 48 nM (ERα) and 870 nM (ERβ). Its S enantiomer has low activity.</p>
    Formula:C30H40Cl2N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:531.56

    Ref: TM-T11173L

  • Estrogen receptor antagonist 7
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    Estrogen receptor antagonist 7

    CAS:
    <p>ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.</p>
    Formula:C23H17N3O4
    Color and Shape:Solid
    Molecular weight:399.4

    Ref: TM-T61909

  • (+)-JJ-74-138
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    (+)-JJ-74-138

    CAS:
    <p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>
    Formula:C22H22F8N2OS
    Color and Shape:Solid
    Molecular weight:514.48

    Ref: TM-T200319

  • LEO 134310
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    LEO 134310

    CAS:
    <p>LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.</p>
    Formula:C34H40N2O8
    Color and Shape:Solid
    Molecular weight:604.69

    Ref: TM-T69930

  • A 74273
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    A 74273

    CAS:
    <p>A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.</p>
    Formula:C44H74N4O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:787.08

    Ref: TM-T26439

  • EN1441
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    EN1441

    CAS:
    <p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>
    Formula:C13H13ClN2O2
    Color and Shape:Solid
    Molecular weight:264.708

    Ref: TM-T206982

  • Estrogen receptor antagonist 6
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    Estrogen receptor antagonist 6

    CAS:
    <p>Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)</p>
    Formula:C25H31F3N2O3
    Color and Shape:Solid
    Molecular weight:464.52

    Ref: TM-T62953

  • AR antagonist 10
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    AR antagonist 10

    CAS:
    <p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>
    Formula:C18H17ClN4O3S
    Color and Shape:Solid
    Molecular weight:404.871

    Ref: TM-T205420

  • PBPE hydrochloride
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    PBPE hydrochloride

    CAS:
    <p>PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.</p>
    Formula:C19H24ClNO
    Color and Shape:Solid
    Molecular weight:317.853

    Ref: TM-T204972

  • Estrogen receptor modulator 11
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    Estrogen receptor modulator 11

    CAS:
    <p>Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.</p>
    Formula:C21H18FNO
    Color and Shape:Solid
    Molecular weight:319.372

    Ref: TM-T205569

  • CymitQuimica logo
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    Mu opioid receptor antagonist 4

    <p>Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki &amp; EC50: 0.38 nM; useful for OUD research.</p>
    Formula:C25H28N2O4S
    Color and Shape:Solid
    Molecular weight:452.57

    Ref: TM-T62768