Endocrinology/Hormones
Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.
Subcategories of "Endocrinology/Hormones"
- Androgen Receptor(229 products)
- Annexin A(16 products)
- Aromatase(22 products)
- Estrogen/progestogen Receptor(56 products)
- GPR(1 products)
- Glucocorticoid Receptor(166 products)
- LHRH(1 products)
- Opioid Receptor(326 products)
- Prostaglandin Receptor(122 products)
- RAAS(90 products)
- Reductase(50 products)
- Somatostatin(57 products)
- Thyroid hormone receptor(THR)(32 products)
- Vasopressin Receptor(48 products)
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Found 3371 products of "Endocrinology/Hormones"
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C108297
CAS:C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.Formula:C30H36FN3O4SPurity:98%Color and Shape:SolidMolecular weight:553.69LNS8801
CAS:LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.Formula:C21H18BrNO3Color and Shape:SolidMolecular weight:412.277Dazucorilant
CAS:Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.Formula:C29H22F4N4O3SColor and Shape:SolidMolecular weight:582.57GPR81 agonist 2
CAS:GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.Formula:C26H27ClN6O5S2Color and Shape:SolidMolecular weight:603.11GLPG0492 (R enantiomer)
CAS:GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.Formula:C19H14F3N3O3Color and Shape:SolidMolecular weight:389.33AVE 0991
CAS:AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.Formula:C29H32N4O5S2Purity:99.73%Color and Shape:SolidMolecular weight:580.72AP5 sodium
CAS:AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.Formula:C28H27FNNaO4Color and Shape:SolidMolecular weight:483.515Estrone acetate
CAS:Estrone acetate (Hogival) is an estrogen derivative and an activator of estrogen receptors (ER). This compound can enhance breast development, stimulate the secretion of pituitary prolactin, and induce both the proliferation and activation of lactotrophs, evidenced by the reduction in prolactin storage granule size and the increase in the volume density of the rough endoplasmic reticulum and Golgi apparatus. Estrone acetate holds potential for endocrinological research and for investigating the mechanisms by which estrogen influences pituitary function, prolactin regulation, and breast tumor models.Formula:C20H24O3Color and Shape:SolidMolecular weight:312.403ORIC-101
CAS:ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.Formula:C34H47NO2Purity:98%Color and Shape:SolidMolecular weight:501.74Estrogen receptor antagonist 4
CAS:Estrogen receptor antagonist 4 blocks ER, impacting cell growth and cancer research potential.Formula:C23H29BF4N4O2Color and Shape:SolidMolecular weight:480.31Androstatrione
CAS:<p>Androstatrione is an androgenic compound.</p>Formula:C19H26O3Color and Shape:SolidMolecular weight:302.41Metahexestrol
CAS:Metahexestrol is an inhibitor of the estrogen receptor (E2R) with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cell line with an ED50 of 1.0 μM. Additionally, Metahexestrol shows inhibitory activity in estrogen receptor-negative MDA-MB-231 cell lines, and its antiproliferative effect is not reversed by estrogen, suggesting that its mechanism may be partially independent of the E2R pathway. Metahexestrol is applicable in research on estrogen-dependent breast cancer.Formula:C18H22O2Color and Shape:SolidMolecular weight:270.366GC 14
CAS:GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.Formula:C26H27NO6Purity:98%Color and Shape:SolidMolecular weight:449.5LIT-001 free base
CAS:LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.Formula:C28H33N7O2SPurity:98%Color and Shape:SolidMolecular weight:531.67Opioid receptor antagonist 1
CAS:<p>Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.</p>Formula:C24H29ClF3NO4Color and Shape:SolidMolecular weight:487.94CH5447240
CAS:CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.Formula:C26H39N5O4SPurity:98%Color and Shape:SolidMolecular weight:517.68ERβ agonist-1
CAS:ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.Formula:C25H36O2Color and Shape:SolidMolecular weight:368.55ID11916
CAS:ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.Formula:C29H27F3N8O3SColor and Shape:SolidMolecular weight:624.637AR antagonist 11
CAS:AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.Formula:C20H17ClN2OColor and Shape:SolidMolecular weight:336.815LEO 134310
CAS:LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.Formula:C34H40N2O8Color and Shape:SolidMolecular weight:604.69
