Endocrinology/Hormones
Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.
Subcategories of "Endocrinology/Hormones"
- Androgen Receptor(230 products)
- Annexin A(16 products)
- Aromatase(23 products)
- Estrogen/progestogen Receptor(66 products)
- GPR(1 products)
- Glucocorticoid Receptor(165 products)
- LHRH(2 products)
- Opioid Receptor(327 products)
- Prostaglandin Receptor(126 products)
- RAAS(89 products)
- Reductase(51 products)
- Somatostatin(57 products)
- Thyroid hormone receptor(THR)(34 products)
- Vasopressin Receptor(48 products)
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Found 3421 products of "Endocrinology/Hormones"
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AT1R antagonist 2
AT1R antagonist 2 is a potent AT1R selective ligand with good AT1R affinity (Ki: 26 nM).Formula:C29H37N5O4S2Color and Shape:SolidMolecular weight:583.77AKR1C3-IN-5
AKR1C3-IN-5 inhibits AKR1C3, key in prostate/breast cancers, with MCF-7 cell IC50 of 9.6 μM.Formula:C34H44N2O7Color and Shape:SolidMolecular weight:592.72U 80215
CAS:U 80215 is an enzyme-competitive inhibitor.Formula:C42H60N8O6SColor and Shape:SolidMolecular weight:805.04Saprisartan potassium
CAS:Saprisartan potassium is an Angiotensin II Type 1 receptor antagonist and antihypertensive agent.Formula:C25H21BrF3KN4O4SColor and Shape:SolidMolecular weight:649.52LNS8801
CAS:LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.Formula:C21H18BrNO3Color and Shape:SolidMolecular weight:412.277NOP agonist-1
CAS:NOP agonist-1 (compound 4) is a nociceptin opioid receptor (NOP) partial agonist that attenuates Parkinsonian disabilities in 6-OHDA hemilesioned rats [1].Formula:C22H34N2Molecular weight:326.52Win 45164
CAS:Win 45164 is an orally active ligand for the glucocorticoid receptor (Glucocorticoid Receptor), exhibiting activity that inhibits the pituitary-adrenal axis. It enhances liver glycogen deposition and thymolysis in adrenalectomized male rats. Additionally, Win 45164 possesses anti-inflammatory properties and is applicable in research related to inflammation and neurological disorders.Formula:C26H27FN2O2Molecular weight:418.503Dazucorilant
CAS:Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.Formula:C29H22F4N4O3SColor and Shape:SolidMolecular weight:582.57AR ligand-44
CAS:AR ligand-44 is an androgen receptor (androgen receptor) ligand that can be utilized in the synthesis of PROTACs such as [ARD-2051].Formula:C23H24ClN3O2Color and Shape:SolidMolecular weight:409.91AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Formula:C24H20N2O4Color and Shape:SolidMolecular weight:400.43A4B17
A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.Formula:C14H7F4NSColor and Shape:SolidMolecular weight:297.27ER degrader 10
CAS:ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.Formula:C28H29F2NO3SColor and Shape:SolidMolecular weight:497.597ErSO-DFP
ErSO-DFP activates a-UPR, targets ERα+ cancer cells with high selectivity, and effectively reduces MCF-7 tumours.Formula:C20H17F5N2O2Color and Shape:SolidMolecular weight:412.35GPR81 agonist 2
CAS:GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.Formula:C26H27ClN6O5S2Color and Shape:SolidMolecular weight:603.11Phenethyl 4-ANPP
CAS:Phenethyl 4-ANPP is a MOR (μ-opioid receptor) agonist with a structure similar to known opioids.Formula:C27H32N2Color and Shape:SolidMolecular weight:384.56LXT34
CAS:LXT34 (Example 2) is a GPR120 agonist with anti-inflammatory properties. This compound enhances GLP-1 formation in the gastrointestinal tract and improves insulin resistance in macrophages and pancreatic cells. LXT34 is applicable in studies related to inflammatory conditions, such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.Formula:C18H21NO3SColor and Shape:SolidMolecular weight:331.43THR-β agonist 4
CAS:THR-β agonist 4 is a potent agonist of THR-β.Formula:C16H11Cl2F2N5O6SColor and Shape:SolidMolecular weight:510.26THR-β agonist 5
CAS:THR-β agonist 5 (compound 54) is a potent THR-β agonist, with an EC 50 of <50 nM [1].Formula:C22H23N5O2Color and Shape:SolidMolecular weight:389.45KF-19418
CAS:KF-19418 is a follicle stimulant that directly activates follicles in vitro and promotes hair growth in vivo.Formula:C21H14N4OColor and Shape:SolidMolecular weight:338.36(E/Z)-OT-R antagonist 1
CAS:(E/Z)-OT-R antagonist 1 is a mixture of the E/Z configurations of OT-R antagonist 1. This compound is a novel, potent, selective, non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activity with an IC50 of 8 nM.Formula:C28H29N3O4Color and Shape:SolidMolecular weight:471.55
