Endocrinology/Hormones

<p>Pratosartan is a selective antagonist of angiotensin II receptor.</p>

<p>L 158338 is an antagonist of the angiotensin receptor.</p>

<p>RU 58642 is an effective systemic antiandrogen for androgen-dependent disorders.</p>

<p>Paraprost consists of 1-glutamic acid, alanine, and glycine. It was used in prostate hypertrophy drug therapy.</p>

<p>TPBM inhibits ERα, non-toxic, blocks E2-ERα gene binding, halts ERα+ cancer cell growth (IC50: 5-9 μM), no effect on estrogen-independent growth.</p>

<p>Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide with affinity for the glucocorticoid receptor. a glucocorticoid with anti-inflammatory.</p>

<p>GPR40 Activator 2 is a highly effective activator of the GPR40 receptor.</p>

<p>SQ 31844 is a representative of the imidazole alcohols-a novel class of renin inhibitors.</p>

<p>UR-7247 is an angiotensin type 1 receptor antagonist with a very long plasma elimination half-life.</p>

<p>MK319 is an AKR1B10 inhibitor.</p>

<p>ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, drug addiction.</p>

<p>Dunnione is an antifungal agent exerting its action primarily through initiation of redox cycling.</p>

L 156373 is an oxytocin antagonist.

<p>GW5638, a prodrug of GW7604, is a unique estrogen receptor antagonist &amp; a pseudo-SERD with potential in breast cancer therapy.</p>

<p>SB-436811 is an antagonist of human urotensin-II receptor.</p>

<p>Ici 174865 is a delta opioid receptor antagonist agent.</p>

<p>Isoflupredone, a synthetic corticosteroid, inhibits inflammation and immune response in animals.</p>

<p>LY 164929 is a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.</p>

<p>FR 62765 is a derivative of WF-3681, an aldose reductase inhibitor.</p>

<p>Paramethasone Acetate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects that can be used in the treatment of systemic lupus</p>

<p>D 15413 is an inhibitor of estrogen-dependent mammary tumors.</p>

<p>MK204 is an inhibitor of AKR1B10, a tumor marker and promising antineoplastic target.</p>

<p>Iodothiouracil is a uracil derivative. It was used as a thyroid antagonist.</p>

(Rac)-ErSO-DFP, an ErSO-DFP derivative, modulates ERα, targets ERα+ breast cancer & resistant tumors (from patent WO2022087234A1).

<p>Levormeloxifene fumarate is an osteoporosis drug and selective estrogen receptor modulator (SERM).</p>

<p>P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.</p>

<p>Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties.</p>

<p>Estredox, an estrogen receptor agonist, is used potentially for the treatment of vasomotor symptoms.</p>

<p>G36 is a cell-permeable non-steroidal antagonist of GPER.</p>

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Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

<p>Y134, an oral estrogen receptor inhibitor, is 121x more selective for ERα (Ki=0.09 nM) over ERβ (Ki=11.31 nM), and blocks ER+ breast cancer cell growth.</p>

<p>AZD9567: potent, selective SGRM, oral, IC50=3.8nM, effective in SCW joint inflammation.</p>

<p>Finrozole (MPV 2213ad) is a novel selective aromatase inhibitor that is partially reversible for breast development.</p>

<p>GLPG0492 is a novel selective androgen receptor modulator.</p>

<p>ML-335, a μ-δ targeted agonist and MOR/DOR ligand, may lead to isomer-biased drugs with pain-relief properties.</p>

<p>LY2881835 is a potent and selective GPR40 agonist.</p>

<p>GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM,</p>

<p>ADL-5747 (ADL-5747 (free base)) (free base) is a delta opioid receptor agonist used in the treatment of neurological disorders, skin and musculoskeletal</p>

<p>MEDICA16: GPR40 agonist, GPR120 partial agonist, ATP-citrate lyase inhibitor, lowers TG, boosts insulin sensitivity in muscle.</p>

<p>Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.</p>

<p>Lorundrostat is an aldosterone synthase inhibitor.</p>

<p>YL-365 is a highly potent and selective GPR34 antagonist that exhibits excellent activity in neuropathic pain models for the study of neurologic diseases.</p>

MK 1903 is a strong, selective HCA2/GPR109A agonist, reducing cAMP in CHO cells with EC50 of 12.9 nM.

<p>GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity.</p>

<p>AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively).</p>

PSB-CB5 (GPR18-IN-32)2 is a GRP18 antagonist with anti-inflammatory activity and can be used to study obesity and metabolic disorders.

<p>CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.</p>

<p>FL104 is a potent agonist of small-molecule urotensin II receptor, pEC50= 7.11.</p>

<p>ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective.</p>