CymitQuimica logo
Endocrinology/Hormones

Endocrinology/Hormones

Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.

Subcategories of "Endocrinology/Hormones"

Show 6 more subcategories

Found 3178 products of "Endocrinology/Hormones"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • SJ1008066
    Targetmol
    + Info

    SJ1008066

    CAS:
    <p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>
    Formula:C21H22N4
    Color and Shape:Solid
    Molecular weight:330.43

    Ref: TM-T201713

  • Glucocorticoid receptor agonist-5
    Targetmol
    + Info

    Glucocorticoid receptor agonist-5

    CAS:
    <p>Glucocorticoid Receptoragonist-5 (compound 4) is an effective glucocorticoid molecule acting as a potent agonist for glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive activities and serves as an ADC cytotoxin.</p>
    Formula:C36H40O7
    Color and Shape:Solid
    Molecular weight:584.7

    Ref: TM-T201729

  • 22-Hydroxy mifepristone
    Targetmol
    + Info

    22-Hydroxy mifepristone

    CAS:
    <p>22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.</p>
    Formula:C29H35NO3
    Color and Shape:Solid
    Molecular weight:445.59

    Ref: TM-T201780

  • Galaxolide
    Targetmol
    + Info

    Galaxolide

    CAS:
    <p>Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).</p>
    Formula:C18H26O
    Color and Shape:Solid
    Molecular weight:258.40

    Ref: TM-T201465

  • Erα-IN-1
    Targetmol
    + Info

    Erα-IN-1

    <p>Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.</p>
    Formula:C16H11FN2
    Color and Shape:Solid
    Molecular weight:250.27

    Ref: TM-T201461

  • Estrogen receptor antagonist 7
    Targetmol
    + Info

    Estrogen receptor antagonist 7

    CAS:
    <p>ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.</p>
    Formula:C23H17N3O4
    Color and Shape:Solid
    Molecular weight:399.4

    Ref: TM-T61909

  • Amoitone B
    Targetmol
    + Info

    Amoitone B

    CAS:
    <p>Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].</p>
    Formula:C22H34O5
    Color and Shape:Solid
    Molecular weight:378.5

    Ref: TM-T85646

  • JDTic Dihydrochloride
    Targetmol
    + Info

    JDTic Dihydrochloride

    CAS:
    <p>JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.</p>
    Formula:C28H41Cl2N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.55

    Ref: TM-T11721L

  • AR antagonist 11
    Targetmol
    + Info

    AR antagonist 11

    CAS:
    <p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>
    Formula:C20H17ClN2O
    Color and Shape:Solid
    Molecular weight:336.815

    Ref: TM-T206875

  • ERβ agonist-1
    Targetmol
    + Info

    ERβ agonist-1

    CAS:
    <p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>
    Formula:C25H36O2
    Color and Shape:Solid
    Molecular weight:368.55

    Ref: TM-T207458

  • Androstatrione
    Targetmol
    + Info

    Androstatrione

    CAS:
    <p>Androstatrione is an androgenic compound.</p>
    Formula:C19H26O3
    Color and Shape:Solid
    Molecular weight:302.41

    Ref: TM-T207371

  • BNTX
    Targetmol
    + Info

    BNTX

    CAS:
    <p>BNTX (7-Benzylidenenaltrexone) is a selective δ1-opioid receptor antagonist. It competitively counteracts the antisecretory effects of DPDPE, Deltorphin 2, and DAMGO. BNTX is applicable in research focused on antinociceptive effects.</p>
    Formula:C27H27NO4
    Color and Shape:Solid
    Molecular weight:429.508

    Ref: TM-T206469

  • Estrogen receptor antagonist 4
    Targetmol
    + Info

    Estrogen receptor antagonist 4

    CAS:
    <p>Estrogen receptor antagonist 4 blocks ER, impacting cell growth and cancer research potential.</p>
    Formula:C23H29BF4N4O2
    Color and Shape:Solid
    Molecular weight:480.31

    Ref: TM-T63106

  • ORIC-101
    Targetmol
    + Info

    ORIC-101

    CAS:
    <p>ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.</p>
    Formula:C34H47NO2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:501.74

    Ref: TM-T16404

  • Estrone acetate
    Targetmol
    + Info

    Estrone acetate

    CAS:
    <p>Estrone acetate (Hogival) is an estrogen derivative and an activator of estrogen receptors (ER). This compound can enhance breast development, stimulate the secretion of pituitary prolactin, and induce both the proliferation and activation of lactotrophs, evidenced by the reduction in prolactin storage granule size and the increase in the volume density of the rough endoplasmic reticulum and Golgi apparatus. Estrone acetate holds potential for endocrinological research and for investigating the mechanisms by which estrogen influences pituitary function, prolactin regulation, and breast tumor models.</p>
    Formula:C20H24O3
    Color and Shape:Solid
    Molecular weight:312.403

    Ref: TM-T206611

  • AP5 sodium
    Targetmol
    + Info

    AP5 sodium

    CAS:
    <p>AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.</p>
    Formula:C28H27FNNaO4
    Color and Shape:Solid
    Molecular weight:483.515

    Ref: TM-T63202

  • AVE 0991
    Targetmol
    + Info

    AVE 0991

    CAS:
    <p>AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.</p>
    Formula:C29H32N4O5S2
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:580.72

    Ref: TM-TQ0057

  • BMS-986118
    Targetmol
    + Info

    BMS-986118

    CAS:
    <p>BMS-986118 is a GPR40 full agonist targeting type II diabetes, prompting insulin release without hypoglycemia risk.</p>
    Formula:C25H28ClF3N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:540.96

    Ref: TM-T26868

  • (±)-J 113397
    Targetmol
    + Info

    (±)-J 113397

    CAS:
    <p>(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist (K(i): cloned human ORL1=1.8 nM).</p>
    Formula:C24H37N3O2
    Color and Shape:Solid
    Molecular weight:399.57

    Ref: TM-T21999

  • LX1
    Targetmol
    + Info

    LX1

    CAS:
    <p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>
    Formula:C22H15F6NO2
    Color and Shape:Solid
    Molecular weight:439.35

    Ref: TM-T200147

  • GLPG0492 (R enantiomer)
    Targetmol
    + Info

    GLPG0492 (R enantiomer)

    CAS:
    <p>GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.</p>
    Formula:C19H14F3N3O3
    Color and Shape:Solid
    Molecular weight:389.33

    Ref: TM-T11410

  • GPR81 agonist 2
    Targetmol
    + Info

    GPR81 agonist 2

    CAS:
    <p>GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.</p>
    Formula:C26H27ClN6O5S2
    Color and Shape:Solid
    Molecular weight:603.11

    Ref: TM-T72772

  • Dazucorilant
    Targetmol
    + Info

    Dazucorilant

    CAS:
    <p>Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i &lt;1 nM, useful for neurological research.</p>
    Formula:C29H22F4N4O3S
    Color and Shape:Solid
    Molecular weight:582.57

    Ref: TM-T38983

  • TD-0212
    Targetmol
    + Info

    TD-0212

    CAS:
    <p>TD-0212: Oral dual antagonist for AT1 (pKi 8.9) &amp; NEP inhibitor (pIC50 9.2).</p>
    Formula:C28H34FN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:527.65

    Ref: TM-T13125

  • LNS8801
    Targetmol
    + Info

    LNS8801

    CAS:
    <p>LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.</p>
    Formula:C21H18BrNO3
    Color and Shape:Solid
    Molecular weight:412.277

    Ref: TM-T206565

  • C108297
    Targetmol
    + Info

    C108297

    CAS:
    <p>C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.</p>
    Formula:C30H36FN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.69

    Ref: TM-T26935

  • FSH receptor antagonist 1
    Targetmol
    + Info

    FSH receptor antagonist 1

    CAS:
    <p>FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.</p>
    Formula:C33H32N2O2
    Color and Shape:Solid
    Molecular weight:488.619

    Ref: TM-T204299

  • SDM25N hydrochloride
    Targetmol
    + Info

    SDM25N hydrochloride

    CAS:
    <p>δ receptor antagonist</p>
    Formula:C26H27ClN2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:450.96

    Ref: TM-T23341

  • Estrogen receptor-agonist-1
    Targetmol
    + Info

    Estrogen receptor-agonist-1

    CAS:
    <p>Estrogen receptor-agonist-1 (compound 4e) is an estrogen receptor (ER) agonist that binds to ERα with high affinity.</p>
    Formula:C24H22N2O2
    Color and Shape:Solid
    Molecular weight:370.444

    Ref: TM-T204741

  • CymitQuimica logo
    Targetmol
    + Info

    ERRγ agonist-1

    <p>ERRγ agonist-1 can be used in neuropsychological disorders research.</p>
    Formula:C17H21N5O
    Color and Shape:Solid
    Molecular weight:311.38

    Ref: TM-T60772

  • TRβ agonist 1
    Targetmol
    + Info

    TRβ agonist 1

    CAS:
    <p>TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM.</p>
    Formula:C29H25FN2O8
    Color and Shape:Solid
    Molecular weight:548.52

    Ref: TM-T63876

  • PD 134922
    Targetmol
    + Info

    PD 134922

    CAS:
    <p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>
    Formula:C37H61N5O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:719.97

    Ref: TM-T28329

  • rel-SB-612111 hydrochloride
    Targetmol
    + Info

    rel-SB-612111 hydrochloride

    CAS:
    <p>NOP receptor antagonist</p>
    Formula:C24H30Cl3NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.86

    Ref: TM-T23324

  • JNJ-1250132
    Targetmol
    + Info

    JNJ-1250132

    CAS:
    <p>JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.</p>
    Formula:C33H41NO4
    Color and Shape:Solid
    Molecular weight:515.68

    Ref: TM-T27662

  • GPR84 antagonist 3
    Targetmol
    + Info

    GPR84 antagonist 3

    CAS:
    <p>Potent GPR84 antagonist 3 (compound 42), pIC50 8.28, inhibits GTPγS, with good pharmacokinetics.</p>
    Formula:C29H27N5O
    Color and Shape:Solid
    Molecular weight:461.56

    Ref: TM-T62918

  • Androgen receptor degrader-5
    Targetmol
    + Info

    Androgen receptor degrader-5

    CAS:
    <p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>
    Formula:C29H25F4N5O2
    Color and Shape:Solid
    Molecular weight:551.53

    Ref: TM-T200197

  • Sunobinop
    Targetmol
    + Info

    Sunobinop

    CAS:
    <p>Sunobinop (S 117957) is an opioid receptor-like orphan receptor (ORL1) modulator.</p>
    Formula:C26H33N3O3
    Color and Shape:Solid
    Molecular weight:435.56

    Ref: TM-T62482

  • Norbinaltorphimine dihydrochloride
    Targetmol
    + Info

    Norbinaltorphimine dihydrochloride

    CAS:
    <p>Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.</p>
    Formula:C40H45Cl2N3O6
    Purity:98.17% - 99.88%
    Color and Shape:Solid
    Molecular weight:734.71

    Ref: TM-T12241

  • SC13
    Targetmol
    + Info

    SC13

    CAS:
    <p>SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.</p>
    Formula:C26H30N2O5
    Color and Shape:Solid
    Molecular weight:450.53

    Ref: TM-T62722

  • FL442
    Targetmol
    + Info

    FL442

    CAS:
    <p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>
    Formula:C15H13F3N2O
    Color and Shape:Solid
    Molecular weight:294.27

    Ref: TM-T200138

  • LY2066948
    Targetmol
    + Info

    LY2066948

    CAS:
    <p>LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.</p>
    Formula:C30H31NO5S
    Color and Shape:Solid
    Molecular weight:517.64

    Ref: TM-T200177

  • CCG258747
    Targetmol
    + Info

    CCG258747

    CAS:
    <p>CCG258747 is a novel, selective inhibitor of the GRK2 subfamily.</p>
    Formula:C28H27FN4O4
    Color and Shape:Solid
    Molecular weight:502.54

    Ref: TM-T63411

  • MK-6913
    Targetmol
    + Info

    MK-6913

    CAS:
    <p>MK-6913 is a potent and selective agonist of estrogen receptor β.</p>
    Formula:C25H27N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.5

    Ref: TM-T13136

  • Elacestrant S enantiomer dihydrochloride
    Targetmol
    + Info

    Elacestrant S enantiomer dihydrochloride

    <p>Elacestrant (RAD1901) dihydrochloride, an oral ERR degrader, has IC50 of 48 nM (ERα) and 870 nM (ERβ). Its S enantiomer has low activity.</p>
    Formula:C30H40Cl2N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:531.56

    Ref: TM-T11173L

  • A 74273
    Targetmol
    + Info

    A 74273

    CAS:
    <p>A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.</p>
    Formula:C44H74N4O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:787.08

    Ref: TM-T26439

  • Estrogen receptor antagonist 6
    Targetmol
    + Info

    Estrogen receptor antagonist 6

    CAS:
    <p>Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)</p>
    Formula:C25H31F3N2O3
    Color and Shape:Solid
    Molecular weight:464.52

    Ref: TM-T62953

  • (+)-JJ-74-138
    Targetmol
    + Info

    (+)-JJ-74-138

    CAS:
    <p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>
    Formula:C22H22F8N2OS
    Color and Shape:Solid
    Molecular weight:514.48

    Ref: TM-T200319

  • CymitQuimica logo
    Targetmol
    + Info

    Mu opioid receptor antagonist 4

    <p>Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki &amp; EC50: 0.38 nM; useful for OUD research.</p>
    Formula:C25H28N2O4S
    Color and Shape:Solid
    Molecular weight:452.57

    Ref: TM-T62768

  • CymitQuimica logo
    Targetmol
    + Info

    σ1 Receptor/μ Opioid receptor modulator 2

    CAS:
    <p>Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.</p>
    Formula:C23H31N3O
    Molecular weight:365.51

    Ref: TM-T208835

  • RJG-2051
    Targetmol
    + Info

    RJG-2051

    CAS:
    <p>RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.</p>
    Formula:C26H31N5O4S
    Color and Shape:Solid
    Molecular weight:509.62

    Ref: TM-T206799