Endocrinology/Hormones
Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.
Subcategories of "Endocrinology/Hormones"
- Androgen Receptor(229 products)
- Annexin A(16 products)
- Aromatase(23 products)
- Estrogen/progestogen Receptor(66 products)
- GPR(1 products)
- Glucocorticoid Receptor(165 products)
- LHRH(2 products)
- Opioid Receptor(327 products)
- Prostaglandin Receptor(122 products)
- RAAS(89 products)
- Reductase(51 products)
- Somatostatin(57 products)
- Thyroid hormone receptor(THR)(33 products)
- Vasopressin Receptor(48 products)
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Found 3420 products of "Endocrinology/Hormones"
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BMS-986118
CAS:BMS-986118 is a GPR40 full agonist targeting type II diabetes, prompting insulin release without hypoglycemia risk.Formula:C25H28ClF3N4O4Purity:98%Color and Shape:SolidMolecular weight:540.96(±)-J 113397
CAS:(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist (K(i): cloned human ORL1=1.8 nM).Formula:C24H37N3O2Color and Shape:SolidMolecular weight:399.57Amoitone B
CAS:Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].Formula:C22H34O5Color and Shape:SolidMolecular weight:378.5(Rac)-Fidarestat
CAS:(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.Formula:C12H10FN3O4Color and Shape:SolidMolecular weight:279.224Riminkefon
CAS:Riminkefon is a kappa opioid receptor agonist .Formula:C38H57N7O6Color and Shape:SolidMolecular weight:707.9Mu opioid receptor antagonist 8
CAS:Muopioid Receptor Antagonist 8 (368) serves as an antagonist to the μ-opioid receptor, significantly inhibiting the activation of Gi induced by met-enkephalin at the µOR.Formula:C36H35N3O4SColor and Shape:SolidMolecular weight:605.756β-Naltrexol
CAS:6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.Formula:C20H25NO4Purity:99.933%Color and Shape:SolidMolecular weight:343.42KR31173
CAS:KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.Formula:C31H30N8O2Color and Shape:SolidMolecular weight:546.62DS34942424
DS34942424 is an orally potent analgesic which did not exhibit mu opioid receptor agonist activity.Formula:C15H17FN2OColor and Shape:SolidMolecular weight:260.31Mu opioid receptor antagonist 5
Compound NAP: MOR antagonist, crosses blood-brain barrier, EC50: 1.14 nM, Ki: 0.37 nM, useful for OUD research.Formula:C26H29N3O4Color and Shape:SolidMolecular weight:447.53NOP agonist-1
CAS:NOP agonist-1 (compound 4) is a nociceptin opioid receptor (NOP) partial agonist that attenuates Parkinsonian disabilities in 6-OHDA hemilesioned rats [1].Formula:C22H34N2Molecular weight:326.52GPR84 antagonist 1
GPR84 antagonist 1 is a highly selective, high-affinity competitive antagonist of human GPR84.Formula:C26H22N4O2Color and Shape:SolidMolecular weight:422.48Mopivabil
Mopivabil is the angiotensin II receptor antagonist[1].Formula:C14H20O3Color and Shape:SolidMolecular weight:236.31(S)-MCOPPB
CAS:(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.Formula:C26H40N4Color and Shape:SolidMolecular weight:408.623Mepixetil
Mepixetil is a potent angiotensin II receptor antagonist[1].Formula:C12H18N2O3Color and Shape:SolidMolecular weight:238.28Win 45164
CAS:Win 45164 is an orally active ligand for the glucocorticoid receptor (Glucocorticoid Receptor), exhibiting activity that inhibits the pituitary-adrenal axis. It enhances liver glycogen deposition and thymolysis in adrenalectomized male rats. Additionally, Win 45164 possesses anti-inflammatory properties and is applicable in research related to inflammation and neurological disorders.Formula:C26H27FN2O2Molecular weight:418.503JTP-117968
CAS:JTP-117968: Non-steroidal SGRM, glucocorticoid receptor modulator, IC50 = 6.8 nM, offers better inhibitory/activatory balance.Formula:C31H31F3N2O2Color and Shape:SolidMolecular weight:520.59Anticancer agent 257
CAS:Anticanceragent 257 (compound of formula (I)) is an anticancer agent that regulates Nur77 and Nurr1.Formula:C15H9Cl2N3Color and Shape:SolidMolecular weight:302.1585α-reductase-IN-1
CAS:5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase.Formula:C31H37NO5Purity:98%Color and Shape:SolidMolecular weight:503.63Glucocorticoid receptor activator 1
CAS:Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.Formula:C11H15Cl2NO2Color and Shape:SolidMolecular weight:264.15ERα degrader 5
ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.Formula:C29H25F4N3O2SColor and Shape:SolidMolecular weight:555.59AR antagonist 4
AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).Formula:C29H36N4OColor and Shape:SolidMolecular weight:456.62TD-0212
CAS:TD-0212: Oral dual antagonist for AT1 (pKi 8.9) & NEP inhibitor (pIC50 9.2).Formula:C28H34FN3O4SPurity:98%Color and Shape:SolidMolecular weight:527.65Norbinaltorphimine dihydrochloride
CAS:Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.Formula:C40H45Cl2N3O6Purity:98.17% - 99.88%Color and Shape:SolidMolecular weight:734.71Ref: TM-T12241
1mg35.00€5mg80.00€10mg114.00€25mg224.00€50mg388.00€100mg618.00€200mg859.00€1mL*10mM (DMSO)117.00€TD-0212 TFA
CAS:TD-0212 TFA is an oral AT1 receptor antagonist & NEP inhibitor with pKi 8.9 & pIC50 9.2.Formula:C30H35F4N3O6SPurity:98%Color and Shape:SolidMolecular weight:641.67NSC 645827
CAS:NSC 645827 is an inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), with an IC50 of 0.7 μM.Formula:C17H17N5O2Color and Shape:SolidMolecular weight:323.349DS69910557
DS69910557: potent hPTHR1 antagonist, IC50 0.08 μM, oral, for hyperparathyroidism & osteoporosis research.Formula:C32H33Cl2FN4O3Color and Shape:SolidMolecular weight:611.53SB-612111 hydrochloride
SB-612111 is a potent ORL-1 antagonist, with high affinity (Ki: 0.33 nM) and µ-receptor activity (Ki: 57.6 nM), blocking Nociceptin-induced pain.Formula:C24H30Cl3NOColor and Shape:SolidMolecular weight:454.86RX 809055AX
CAS:RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.Formula:C29H29ClN2O4Color and Shape:SolidMolecular weight:505MLS000389544
CAS:MLS000389544 is a selective and potent thyroid hormone receptor β (TRβ) antagonist with a methylsulfonyl nitrobenzoic acid structure. It effectively inhibits the interaction between TRβ and steroid receptor coactivator 2 (SRC2).Formula:C20H24N2O7SColor and Shape:SolidMolecular weight:436.479S-HP210
S-HP210: selective GR modulator, blocks NF-κB (IC50: 1.92 μM), non-toxic to mouse fibroblasts.Formula:C22H19N3O2S2Color and Shape:SolidMolecular weight:421.54AKR1C3-IN-8
AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity.Formula:C23H20N4O3Color and Shape:SolidMolecular weight:400.43TUG-2181
CAS:TUG-2181 is an antagonist of GPR84, with an IC50 value of 34 nM. It inhibits reactive oxygen species (ROS) production and IL-8 secretion induced by GPR84 agonists in human neutrophils. TUG-2181 is applicable for research in inflammation and fibrosis.
Formula:C21H27NO4Color and Shape:SolidMolecular weight:357.443CI 992
CAS:CI 992 is a novel potent inhibitor of primate renin.Formula:C33H52N6O7S2Color and Shape:SolidMolecular weight:708.93BW 443C
CAS:BW 443C is a selective agonist of mu-opioid receptor.Formula:C33H46N10O10Color and Shape:SolidMolecular weight:742.791Mu opioid receptor antagonist 2
Compound 25: potent, selective MOR antagonist, crosses blood-brain barrier (Ki: 0.37 nM, EC50: 0.44 nM), for OUD research.Formula:C25H28N2O4SColor and Shape:SolidMolecular weight:452.57THR-β agonist 5
CAS:THR-β agonist 5 (compound 54) is a potent THR-β agonist, with an EC 50 of <50 nM [1].Formula:C22H23N5O2Color and Shape:SolidMolecular weight:389.45GNTI dihydrochloride
CAS:κ opioid receptor antagonistFormula:C27H30ClN5O3Purity:98%Color and Shape:SolidMolecular weight:508.01SB-612111
CAS:SB-612111: potent ORL-1 antagonist, Ki=0.33 nM; μ-, κ-, δ-receptor Ki=57.6, 160.5, 2109 nM; blocks nociceptin's pain effect.Formula:C24H29Cl2NOColor and Shape:SolidMolecular weight:418.40σ1 Receptor/μ Opioid receptor modulator 2
CAS:Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.Formula:C23H31N3OMolecular weight:365.51J-113397
CAS:J-113397 is a potent and selective NOP receptor antagonist (IC50 = 2.3 nM).Formula:C24H37N3O2Purity:98%Color and Shape:SolidMolecular weight:399.57PD 134922
CAS:PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.Formula:C37H61N5O7SPurity:98%Color and Shape:SolidMolecular weight:719.97Androgen receptor degrader-5
CAS:Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.Formula:C29H25F4N5O2Color and Shape:SolidMolecular weight:551.53SC13
CAS:SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.Formula:C26H30N2O5Color and Shape:SolidMolecular weight:450.53BMS-986034
CAS:BMS-986034 is a GPR119 agonist.Formula:C24H24Cl2N6O4Color and Shape:SolidMolecular weight:531.39PROTAC Androgen receptor degrader-1
CAS:PROTAC Androgen receptor degrader-1 is a PROTAC degrader targeting the androgen receptor (DC50 = 6 nM), prostate cancer.Formula:C43H48ClN9O2Purity:99.49%Color and Shape:SolidMolecular weight:758.35RJG-2051
CAS:RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.Formula:C26H31N5O4SColor and Shape:SolidMolecular weight:509.62FL442
CAS:FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).Formula:C15H13F3N2OColor and Shape:SolidMolecular weight:294.27Mu opioid receptor antagonist 4
Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki & EC50: 0.38 nM; useful for OUD research.Formula:C25H28N2O4SColor and Shape:SolidMolecular weight:452.57Estrogen receptor antagonist 6
CAS:Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)Formula:C25H31F3N2O3Color and Shape:SolidMolecular weight:464.52
