Endocrinology/Hormones

Procymidone is a broad-spectrum fungicide that inhibits fungal glycerol triester synthesis, thereby disrupting hyphal growth. androgen receptor (AR) antagonist

JNJ-37654032: orally active, nonsteroidal SARM. Mixed AR agonist/antagonist. Selective for muscle, grows levator ani, max at 3mg/kg, ED(50) 0.8mg/kg.

4'-Raloxifene-β-D-glucopyranoside is a metabolite of Raloxifene.

Timobesone is a topical corticosteroid.

Diisopropyl phthalate is widely used as an additive in plastics and consumer products in the chemical industries.

Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor.

<p>D-Kynurenine, ZINC901103, metabolizes from D-tryptophan, activates AhR, changes epithelium to mesenchyme, and tests for D-amino acid oxidase.</p>

Flumethasone pivalate: antipruritic, anti-inflammatory, and vasoconstrictor; for adrenocortical suppression, skin atrophy, and telangiectasia studies.

Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).

<p>Lipidated Oxytocin analog with long-lasting activities. Product has the following disulfide bonds: Cys1-Cys6 and is available as a 0.5mg vial.</p>

<p>Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 is in the glucagon family. Exendin 3 stimulates vasoactive intestinal peptide (VIP) receptors in high concentrations. This leads to increased cAMP levels and amylase secretion in the pancreas. However, low exendin-3 exposure only increases cAMP levels. In applications, exendin-3 was found to induce hypotension by relaxation of cardiac, smooth muscle. Using a tag, exendin-3 is being investigated as a stable agonist for GLP1R to detect insulinomas, a pancreatic B cell-derived cancer with high GLP1R expression. Exendin 3 has also been used on mouse models to assess its effect on glucose-stimulated insulin secretion in glucagon receptor knockout (Gcgr-/-) backgrounds. Understanding the interplay between exendin 3 and metabolism could provide new insights into the obesity crisis.</p>

Fluticasone furoate (Avamys), a potent, trifluorinated steroid with anti-inflammatory effects, treats allergic rhinitis.

<p>Liraglutide is sold under the brand name €˜Victoza' and is a medication used to treat diabetes mellitus type 2 and obesity.Liraglutide binds to and activates the GLP-1 (glucagon-like peptide-1) receptor to bring about an increase in insulin secretion and a decrease in glucagon secretion and gastric emptying.</p>

OT antagonist 1 is a potent and selective antagonist of Oxytocin(Ki of 50 nM)

<p>Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1].</p>

MK-3984 is a selective androgen receptor modulator, used in the study of conditions caused by androgen deficiency.

OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.

Capesaris (GTX-758) is an oral estrogen receptor α agonist, used in prostate cancer research.

PF-4455242 HCl is a selective and orally available κ-opioid receptor antagonist that exhibiting antidepressant effects.