NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 398 products of "NF-κB"
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Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Formula:C18H19F3N2O2SeMolecular weight:432.0563812-Oxo phytodienoic acid
CAS:12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.
Formula:C18H28O3Purity:98%Color and Shape:SolidMolecular weight:292.41Halleridone
CAS:Halleridone, a natural product, is identified in Teuanchum decipiens and Abeliophyllum distichum.Formula:C8H10O3Color and Shape:SolidMolecular weight:154.165SN50M
CAS:SN50M (NF-κB Control) is a synthetic peptide containing a hydrophobic region and mutant nuclear localization sequences that can enter cells.Formula:C123H215N33O30SColor and Shape:SolidMolecular weight:2668.29BIZ 114
CAS:BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.Formula:C24H40O3Color and Shape:SolidMolecular weight:376.57IRAK4-IN-10
CAS:IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.Formula:C22H24N8Purity:98.55%Color and Shape:SolidMolecular weight:400.48Hesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formula:C29H36O15Purity:99.53%Color and Shape:Yellow PowderMolecular weight:624.59DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Color and Shape:SolidMolecular weight:525.6ML 120B dihydrochloride
CAS:MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Formula:C19H17Cl3N4O2Color and Shape:SolidMolecular weight:439.72SEMBL
CAS:SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.Formula:C12H11NO4Purity:98%Color and Shape:SolidMolecular weight:233.22RS 09
CAS:TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.Formula:C31H49N9O9Purity:98%Color and Shape:SolidMolecular weight:691.78Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Formula:C37H42Cl2N2O6Purity:95% - 99.99%Color and Shape:SolidMolecular weight:681.65Ginsenoside Rg2
CAS:Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Formula:C42H72O13Purity:99.77% - 99.78%Color and Shape:SolidMolecular weight:785.01Ref: TM-T2873
2mg37.00€5mg52.00€10mg88.00€25mg131.00€50mg188.00€100mg279.00€500mg658.00€1mL*10mM (DMSO)87.00€Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purity:97.79% - >99.99%Color and Shape:Yellow SolidMolecular weight:384.24Ref: TM-T2399
5mg50.00€10mg60.00€25mg75.00€50mg92.00€100mg137.00€200mg213.00€500mg353.00€1mL*10mM (DMSO)50.00€IRAK-4 protein kinase inhibitor 2
CAS:IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Formula:C14H10N4O3Purity:99.5%Color and Shape:SolidMolecular weight:282.25Ginsenoside Rg6
CAS:Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cellsFormula:C42H70O12Purity:97.34%Color and Shape:SolidMolecular weight:767Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formula:C24H30O14Purity:99.86% - >99.99%Color and Shape:SolidMolecular weight:542.49Ref: TM-T4S2326
1mg96.00€5mg264.00€10mg415.00€25mg677.00€50mg935.00€100mg1,254.00€500mg2,527.00€1mL*10mM (DMSO)315.00€Benzoyloxypaeoniflorin
CAS:Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Formula:C30H32O13Purity:98.52% - 99.96%Color and Shape:SolidMolecular weight:600.57Ref: TM-T4S1658
1mg120.00€5mg281.00€10mg409.00€25mg660.00€50mg888.00€100mg1,224.00€1mL*10mM (DMSO)358.00€Pyrrolidinedithiocarbamate ammonium
CAS:Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxideFormula:C5H12N2S2Purity:98% - >99.99%Color and Shape:Off-White To Pale Yellow CrystalsMolecular weight:164.29Myrislignan
CAS:Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.
Formula:C21H26O6Purity:98.77% - 99.41%Color and Shape:SolidMolecular weight:374.43Stachydrine
CAS:Stachydrine, found in leonurus herb, aids blood flow, blocks NF-κB pathway, and indicates citrus intake.
Formula:C7H13NO2Purity:99.94% - ≥95%Color and Shape:SolidMolecular weight:143.18Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormula:C31H30O8Purity:99.03%Color and Shape:SolidMolecular weight:530.57Ref: TM-T9105
1mg166.00€5mg341.00€10mg550.00€25mg898.00€50mg1,216.00€100mg1,644.00€1mL*10mM (DMSO)398.00€Berbamine
CAS:Berbamine is a natural product extracted from Phellodendron amurense.Formula:C37H40N2O6Purity:98.92% - 99.67%Color and Shape:White Crystal PowderMolecular weight:608.72Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Formula:C13H15NO2SPurity:99.76% - 99.94%Color and Shape:White SolidMolecular weight:249.33Ref: TM-T1934
2mg35.00€5mg50.00€10mg66.00€25mg85.00€50mg124.00€100mg197.00€200mg255.00€1mL*10mM (DMSO)62.00€BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formula:C14H17N5Purity:99.36% - 99.74%Color and Shape:SolidMolecular weight:255.32Sulfuretin
CAS:Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.
Formula:C15H10O5Purity:98.91% - 99.86%Color and Shape:SolidMolecular weight:270.241-Caffeoylquinic acid
CAS:1-Caffeoylquinic acid: a lignin precursor with anti-influenza, antioxidant properties, and moderates post-meal glucose release.Formula:C16H18O9Purity:99.15% - 99.16%Color and Shape:SolidMolecular weight:354.31BEC hydrochloride
CAS:BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.Formula:C5H12BNO4S·ClHPurity:98.65% - 99.28%Color and Shape:SolidMolecular weight:229.49Ref: TM-T6779
1mg39.00€5mg88.00€10mg153.00€25mg283.00€50mg464.00€100mg663.00€200mg919.00€1mL*10mM (DMSO)88.00€Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27% - 99.53%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64QNZ
CAS:QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.Formula:C22H20N4OPurity:99.17% - 99.18%Color and Shape:White SolidMolecular weight:356.42Ref: TM-T6204
1mg43.00€2mg57.00€5mg93.00€10mg140.00€25mg188.00€50mg329.00€100mg490.00€200mg710.00€1mL*10mM (DMSO)93.00€TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formula:C27H46ClNO2Purity:99.75% - ≥95%Color and Shape:SolidMolecular weight:452.11IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Ref: TM-T9010
1mg40.00€5mg96.00€10mg135.00€25mg226.00€50mg320.00€100mg434.00€200mg602.00€1mL*10mM (DMSO)131.00€2,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formula:C8H8O3Purity:99.75%Color and Shape:Yellow PowderMolecular weight:152.15Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formula:C25H24O6Purity:98.68% - 99.8%Color and Shape:SolidMolecular weight:420.45CAFESTOL
CAS:Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Formula:C20H28O3Purity:97.06% - 99.08%Color and Shape:SolidMolecular weight:316.43EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formula:C18H18ClMnN2O4Purity:98.39%Color and Shape:SolidMolecular weight:416.743'-Sialyllactose
CAS:3'-Sialyllactose (3'-SL), a prebiotic, supports immunity, reduces inflammation and arthritis, and is low-toxicity for research.Formula:C23H39NO19Color and Shape:SolidMolecular weight:633.55Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formula:C21H22O11Purity:98.63% - 99.54%Color and Shape:SolidMolecular weight:450.39Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFormula:C19H18NO4Purity:98.08% - 99.18%Color and Shape:SolidMolecular weight:324.35Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purity:99.12% - 99.76%Color and Shape:SolidMolecular weight:1109.29OPHIOPOGONIN D
CAS:Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Formula:C44H70O16Purity:99.46% - ≥95%Color and Shape:SolidMolecular weight:855.02Zimlovisertib
CAS:Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).Formula:C18H20FN3O4Purity:98.21%Color and Shape:SolidMolecular weight:361.372-Hydroxychalcone
CAS:2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.Formula:C15H12O2Purity:99.6%Color and Shape:SolidMolecular weight:224.25Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Formula:C17H20O5Purity:98.2% - 99.36%Color and Shape:SolidMolecular weight:304.34Ref: TM-T3S1707
1mg99.00€2mg138.00€5mg215.00€10mg319.00€25mg530.00€50mg755.00€100mg1,018.00€1mL*10mM (DMSO)234.00€(E/Z)-IT-603
CAS:(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.Formula:C11H9BrN2O3SPurity:99.35%Color and Shape:SolidMolecular weight:329.17Ref: TM-T8799
1mg56.00€5mg119.00€10mg192.00€25mg356.00€50mg565.00€100mg802.00€200mg1,099.00€1mL*10mM (DMSO)133.00€Vanillic Acid
CAS:Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.Formula:C8H8O4Purity:99.82%Color and Shape:White Odourless Crystals Or PowderMolecular weight:168.15Ginsenoside Rd
CAS:Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:99.13% - 99.92%Color and Shape:SolidMolecular weight:947.15Ref: TM-T2878
1mg37.00€5mg71.00€10mg99.00€25mg170.00€50mg260.00€100mg394.00€200mg570.00€1mL*10mM (DMSO)124.00€Flaconitine
CAS:Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.
Formula:C36H49NO12Purity:98% - 99.84%Color and Shape:SolidMolecular weight:687.77Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Formula:C27H30O14Purity:98.11% - 98.58%Color and Shape:SolidMolecular weight:578.52
