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NF-κB

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.

Found 445 products of "NF-κB"

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  • PS 1145 dihydrochloride
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    PS 1145 dihydrochloride

    CAS:
    <p>IκB kinase (IKK) inhibitor</p>
    Formula:C17H13Cl3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.67

    Ref: TM-T23191

  • Nasunin
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    Nasunin

    CAS:
    <p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>
    Formula:C42H47ClO23
    Color and Shape:Solid
    Molecular weight:955.26

    Ref: TM-T31371

  • Cyclo(L-Pro-L-Val)
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    Cyclo(L-Pro-L-Val)

    CAS:
    <p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>
    Formula:C10H16N2O2
    Purity:98.18%
    Color and Shape:Solid
    Molecular weight:196.25

    Ref: TM-T125120

  • Ginger extract
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    Ginger extract

    CAS:
    <p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>
    Color and Shape:Solid

    Ref: TM-T40939

  • TBK1/IKKε-IN-6
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    TBK1/IKKε-IN-6

    CAS:
    <p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>
    Formula:C31H36F2N8O4
    Color and Shape:Solid
    Molecular weight:622.678

    Ref: TM-T39841

  • NF-κΒ activator 1
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    NF-κΒ activator 1

    CAS:
    <p>NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.</p>
    Formula:C16H11FN2O2S
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:314.33

    Ref: TM-T39965

  • CAY10657
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    CAY10657

    CAS:
    <p>CAY10657 has a wide range of applications in life science related research.</p>
    Formula:C17H20N4O3S
    Color and Shape:Solid
    Molecular weight:360.43

    Ref: TM-T38368

  • CymitQuimica logo
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    PROTAC STING degrader-3

    <p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206857

  • Lemnalol
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    Lemnalol

    CAS:
    <p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>
    Formula:C15H24O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:220.35

    Ref: TM-T25658

  • Pratensein
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    Pratensein

    CAS:
    <p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>
    Formula:C16H12O6
    Purity:99.90%
    Color and Shape:Solid
    Molecular weight:300.26

    Ref: TM-TN2100

  • Gliotoxin
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    Gliotoxin

    CAS:
    <p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>
    Formula:C13H14N2O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-TN1694

  • NF-κB Signaling Compound Library
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    NF-κB Signaling Compound Library

    <p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>
    Color and Shape:Odour Solid

    Ref: TM-L3800

  • CymitQuimica logo
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    MJ210

    <p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206491

  • CymitQuimica logo
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    NF-κB-IN-12

    <p>NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].</p>
    Formula:C30H26N6O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:582.63

    Ref: TM-T78882

  • N-Acetyldopamine dimer-2
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    N-Acetyldopamine dimer-2

    CAS:
    <p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>
    Formula:C20H20N2O6
    Color and Shape:Solid
    Molecular weight:384.38

    Ref: TM-T75537

  • SN50 TFA
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    SN50 TFA

    <p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>
    Formula:C129H230N36O29S·XCF3COOH
    Color and Shape:Solid
    Molecular weight:2781.5 (free base)

    Ref: TM-T38153

  • Diprovocim-1
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    Diprovocim-1

    CAS:
    <p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 &amp; CTLs against tumors with anti-PD-L1 in mice.</p>
    Formula:C56H56N6O6
    Color and Shape:Solid
    Molecular weight:909.1

    Ref: TM-T37722

  • CymitQuimica logo
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    Anti-osteoporosis agent-8

    <p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>
    Formula:C18H19F3N2O2Se
    Molecular weight:432.05638

    Ref: TM-T209668

  • IRAK4-IN-8
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    IRAK4-IN-8

    CAS:
    <p>IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.</p>
    Formula:C23H23F2N7O2S
    Purity:99.33%
    Color and Shape:Solid
    Molecular weight:499.54

    Ref: TM-T63388

  • IRAK4-IN-10
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    IRAK4-IN-10

    CAS:
    <p>IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.</p>
    Formula:C22H24N8
    Purity:98.55%
    Color and Shape:Solid
    Molecular weight:400.48

    Ref: TM-T61931

  • IRAK inhibitor 2
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    IRAK inhibitor 2

    CAS:
    <p>IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.</p>
    Formula:C17H14N4O2
    Purity:97.90% - 99.58%
    Color and Shape:Solid
    Molecular weight:306.32

    Ref: TM-T7368

  • DTP3
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    DTP3

    CAS:
    <p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>
    Formula:C26H35N7O5
    Color and Shape:Solid
    Molecular weight:525.6

    Ref: TM-T22319

  • Hesperidin methylchalcone
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    Hesperidin methylchalcone

    CAS:
    <p>Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.</p>
    Formula:C29H36O15
    Purity:99.53%
    Color and Shape:Yellow Powder
    Molecular weight:624.59

    Ref: TM-T7980

  • ML 120B dihydrochloride
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    ML 120B dihydrochloride

    CAS:
    <p>MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.</p>
    Formula:C19H17Cl3N4O2
    Color and Shape:Solid
    Molecular weight:439.72

    Ref: TM-T39199

  • BIZ 114
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    BIZ 114

    CAS:
    <p>BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.</p>
    Formula:C24H40O3
    Color and Shape:Solid
    Molecular weight:376.57

    Ref: TM-T13583

  • Edecesertib
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    Edecesertib

    CAS:
    <p>Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.</p>
    Formula:C22H22FN7O2
    Purity:98.84% - 99.94%
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T62473

  • RS 09
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    RS 09

    CAS:
    <p>TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.</p>
    Formula:C31H49N9O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:691.78

    Ref: TM-TP1938

  • TOMATIDINE HYDROCHLORIDE
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    TOMATIDINE HYDROCHLORIDE

    CAS:
    <p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>
    Formula:C27H46ClNO2
    Purity:99.75% - ≥95%
    Color and Shape:Solid
    Molecular weight:452.11

    Ref: TM-T4592

  • QNZ
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    QNZ

    CAS:
    <p>QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.</p>
    Formula:C22H20N4O
    Purity:99.17% - 99.18%
    Color and Shape:White Solid
    Molecular weight:356.42

    Ref: TM-T6204

  • BEC hydrochloride
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    BEC hydrochloride

    CAS:
    <p>BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.</p>
    Formula:C5H12BNO4S·ClH
    Purity:98.65% - 99.28%
    Color and Shape:Solid
    Molecular weight:229.49

    Ref: TM-T6779

  • Neochlorogenic acid
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    Neochlorogenic acid

    CAS:
    <p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>
    Formula:C16H18O9
    Purity:99.12% - 99.54%
    Color and Shape:White Powder
    Molecular weight:354.31

    Ref: TM-T6S1538

  • CAFESTOL
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    CAFESTOL

    CAS:
    <p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>
    Formula:C20H28O3
    Purity:97.06% - 99.08%
    Color and Shape:Solid
    Molecular weight:316.43

    Ref: TM-T5727

  • Demethyleneberberine
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    Demethyleneberberine

    CAS:
    <p>Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either</p>
    Formula:C19H18NO4
    Purity:98.08% - 99.18%
    Color and Shape:Solid
    Molecular weight:324.35

    Ref: TM-T4S0800

  • Morusin
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    Morusin

    CAS:
    <p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>
    Formula:C25H24O6
    Purity:98.68% - 99.8%
    Color and Shape:Solid
    Molecular weight:420.45

    Ref: TM-T5S1607

  • EUK-134
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    EUK-134

    CAS:
    <p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>
    Formula:C18H18ClMnN2O4
    Purity:98.39%
    Color and Shape:Solid
    Molecular weight:416.74

    Ref: TM-T6495

  • Flavanomarein
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    Flavanomarein

    CAS:
    <p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>
    Formula:C21H22O11
    Purity:98.63% - 99.54%
    Color and Shape:Solid
    Molecular weight:450.39

    Ref: TM-TN1644

  • Articaine
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    Articaine

    CAS:
    <p>Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-</p>
    Formula:C13H20N2O3S
    Color and Shape:Solid
    Molecular weight:284.37

    Ref: TM-T73337

  • Triacetylresveratrol
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    Triacetylresveratrol

    CAS:
    <p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>
    Formula:C20H18O6
    Purity:99.81%
    Color and Shape:Off White Powder
    Molecular weight:354.35

    Ref: TM-T5668

  • 3'-Sialyllactose
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    3'-Sialyllactose

    CAS:
    <p>3'-Sialyllactose (3'-SL), a prebiotic, supports immunity, reduces inflammation and arthritis, and is low-toxicity for research.</p>
    Formula:C23H39NO19
    Color and Shape:Solid
    Molecular weight:633.55

    Ref: TM-T72655

  • OPHIOPOGONIN D
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    OPHIOPOGONIN D

    CAS:
    <p>Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.</p>
    Formula:C44H70O16
    Purity:99.46% - ≥95%
    Color and Shape:Solid
    Molecular weight:855.02

    Ref: TM-T5701

  • yangonin
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    yangonin

    CAS:
    <p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>
    Formula:C15H14O4
    Purity:98.82% - 99.55%
    Color and Shape:Pale Yellow Powder
    Molecular weight:258.27

    Ref: TM-T3S0738

  • BI-69A11
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    BI-69A11

    CAS:
    <p>BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.</p>
    Formula:C25H16ClN3O2
    Purity:96.97%
    Color and Shape:Solid
    Molecular weight:425.87

    Ref: TM-T25150

  • Iron sucrose
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    Iron sucrose

    CAS:
    <p>Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.</p>
    Formula:C18H24Fe2O24
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:736.1

    Ref: TM-T8132

  • IMM-H007
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    IMM-H007

    CAS:
    <p>IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression</p>
    Formula:C22H23N5O8
    Purity:97.73%
    Color and Shape:Solid
    Molecular weight:485.45

    Ref: TM-T9010

  • Sulfuretin
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    Sulfuretin

    CAS:
    <p>Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.</p>
    Formula:C15H10O5
    Purity:98.91% - 99.86%
    Color and Shape:Solid
    Molecular weight:270.24

    Ref: TM-TN2244

  • Flaconitine
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    Flaconitine

    CAS:
    <p>Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.</p>
    Formula:C36H49NO12
    Purity:98% - 99.84%
    Color and Shape:Solid
    Molecular weight:687.77

    Ref: TM-T5S1891

  • Vanillic Acid
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    Vanillic Acid

    CAS:
    <p>Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.</p>
    Formula:C8H8O4
    Purity:99.82%
    Color and Shape:White Odourless Crystals Or Powder
    Molecular weight:168.15

    Ref: TM-T9115

  • 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
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    2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC

    CAS:
    <p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>
    Formula:C11H10N2OS
    Purity:99.48%
    Color and Shape:Solid
    Molecular weight:218.27

    Ref: TM-T8910

  • BOT-64
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    BOT-64

    CAS:
    <p>BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole</p>
    Formula:C15H15NO2S
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:273.35

    Ref: TM-T8705

  • 18α-Glycyrrhetinic acid
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    18α-Glycyrrhetinic acid

    CAS:
    <p>18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.</p>
    Formula:C30H46O4
    Purity:98.54% - 99.68%
    Color and Shape:Solid
    Molecular weight:470.68

    Ref: TM-T2745