IκB/IKK
The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.
Found 58 products of "IκB/IKK"
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SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Formula:C9H8N2OS2Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:224.3BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formula:C14H17N5Purity:99.36% - 99.74%Color and Shape:SolidMolecular weight:255.32TBK1/IKKε-IN-5
CAS:TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).Formula:C28H31N7O3Purity:98.77%Color and Shape:SolidMolecular weight:513.59Ref: TM-T7951
1mg88.00€5mg182.00€10mg269.00€25mg429.00€50mg587.00€100mg837.00€200mg1,125.00€1mL*10mM (DMSO)224.00€JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formula:C17H13NaO4Purity:99.95%Color and Shape:SolidMolecular weight:304.27Ref: TM-T8951
1mg37.00€2mg50.00€5mg65.00€10mg95.00€25mg210.00€50mg339.00€100mg495.00€500mg1,099.00€1mL*10mM (DMSO)77.00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Formula:C11H10N2OSPurity:99.48%Color and Shape:SolidMolecular weight:218.27BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formula:C14H18ClN5Purity:99.13%Color and Shape:SolidMolecular weight:291.78Ref: TM-T8542
1mg38.00€2mg50.00€5mg82.00€10mg119.00€25mg212.00€50mg356.00€100mg533.00€1mL*10mM (DMSO)52.00€BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormula:C15H15NO2SPurity:99.73%Color and Shape:SolidMolecular weight:273.35Ref: TM-T8705
1mg50.00€5mg110.00€10mg170.00€25mg323.00€50mg494.00€100mg665.00€200mg893.00€1mL*10mM (DMSO)102.00€IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formula:C15H8ClF6NO2Purity:99.65% - 99.98%Color and Shape:SolidMolecular weight:383.67Ref: TM-T6141
2mg46.00€5mg63.00€10mg87.00€25mg155.00€50mg210.00€100mg294.00€500mg713.00€1mL*10mM (DMSO)65.00€NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormula:C31H30O8Purity:99.03%Color and Shape:SolidMolecular weight:530.57Ref: TM-T9105
1mg166.00€5mg341.00€10mg550.00€25mg898.00€50mg1,216.00€100mg1,644.00€1mL*10mM (DMSO)398.00€INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formula:C15H16N2OPurity:95.41%Color and Shape:SolidMolecular weight:240.3GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45Ertiprotafib
CAS:Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.
Formula:C31H27BrO3SPurity:98.70%Color and Shape:SolidMolecular weight:559.51TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFormula:C28H35N7O4Color and Shape:SolidMolecular weight:533.62PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Formula:C29H27ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:560.02DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formula:C19H17FN8Color and Shape:SolidMolecular weight:376.39IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formula:C12H11N3O2SPurity:99.83%Color and Shape:SolidMolecular weight:261.3Ref: TM-T36524
1mg108.00€5mg261.00€10mg401.00€25mg622.00€50mg837.00€100mg1,125.00€200mg1,504.00€500µg82.00€1-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Formula:C21H30O4Color and Shape:SolidMolecular weight:346.46CS12192
CAS:CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Formula:C25H23ClFN7O2Color and Shape:SolidMolecular weight:507.95
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