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Nrf2

Nrf2

Nrf2 is a transcription factor that regulates the expression of antioxidant proteins and detoxification enzymes, playing a pivotal role in cellular defense against oxidative stress and inflammation. Activation of Nrf2 signaling provides protection against various diseases, including cancer, neurodegeneration, and cardiovascular disorders. Nrf2 modulators are being explored for their potential therapeutic applications in reducing oxidative damage and inflammation. At CymitQuimica, we provide a range of high-quality Nrf2 pathway modulators to support your research in oxidative stress, inflammation, and disease prevention.

Found 79 products of "Nrf2"

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  • MSU38225
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    MSU38225

    CAS:
    <p>MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.</p>
    Formula:C21H19N3
    Color and Shape:Solid
    Molecular weight:313.4

    Ref: TM-T79146

  • (+)-DHMEQ
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    (+)-DHMEQ

    CAS:
    <p>(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.</p>
    Formula:C13H11NO5
    Color and Shape:Solid
    Molecular weight:261.23

    Ref: TM-T13462

  • Dihydrolipoic acid
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    Dihydrolipoic acid

    CAS:
    <p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>
    Formula:C8H16O2S2
    Purity:97.51%
    Color and Shape:Yellow To Orange Liquid
    Molecular weight:208.34

    Ref: TM-T21233

  • Keap1-Nrf2-IN-12
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    Keap1-Nrf2-IN-12

    CAS:
    <p>eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.</p>
    Formula:C26H28N2O10S2
    Color and Shape:Solid
    Molecular weight:592.64

    Ref: TM-T64190

  • Keap1-Nrf2-IN-13
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    Keap1-Nrf2-IN-13

    CAS:
    <p>Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.</p>
    Formula:C28H32N2O10S2
    Color and Shape:Solid
    Molecular weight:620.69

    Ref: TM-T72706

  • Nrf2 activator-5
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    Nrf2 activator-5

    CAS:
    <p>Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.</p>
    Formula:C25H30Cl2O6
    Color and Shape:Solid
    Molecular weight:497.41

    Ref: TM-T63364

  • Keap1-Nrf2-IN-14
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    Keap1-Nrf2-IN-14

    CAS:
    <p>Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.</p>
    Formula:C30H29NO8S
    Color and Shape:Solid
    Molecular weight:563.62

    Ref: TM-T63987

  • NXPZ-2
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    NXPZ-2

    CAS:
    <p>NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.</p>
    Formula:C27H27N5O7S2
    Color and Shape:Solid
    Molecular weight:597.66

    Ref: TM-T64214

  • SPC-180002
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    SPC-180002

    CAS:
    <p>SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.</p>
    Formula:C18H23NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:317.38

    Ref: TM-T79601

  • Stigmane B
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    Stigmane B

    <p>Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.</p>
    Formula:C21H30O4
    Color and Shape:Solid
    Molecular weight:346.46

    Ref: TM-T73201

  • BPK-29
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    BPK-29

    CAS:
    <p>BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.</p>
    Formula:C26H32ClN3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:470

    Ref: TM-T13586

  • AI-3
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    AI-3

    CAS:
    <p>Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor</p>
    Formula:C11H13ClO3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:292.8

    Ref: TM-T22556

  • Nrf2 activator-4
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    Nrf2 activator-4

    CAS:
    <p>Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.</p>
    Formula:C23H24ClF3N2O3
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:468.9

    Ref: TM-T63016

  • K67
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    K67

    CAS:
    <p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>
    Formula:C29H30N2O7S2
    Purity:98.43%
    Color and Shape:Solid
    Molecular weight:582.69

    Ref: TM-T27709

  • DDO-7263
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    DDO-7263

    CAS:
    <p>DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.</p>
    Formula:C14H9F2N3O
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:273.24

    Ref: TM-T60487

  • CDDO-EA
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    CDDO-EA

    CAS:
    <p>CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.</p>
    Formula:C33H46N2O3
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:518.73

    Ref: TM-T10733

  • Keap1-Nrf2-IN-15
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    Keap1-Nrf2-IN-15

    CAS:
    <p>Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence</p>
    Formula:C39H35N3O12S2
    Color and Shape:Solid
    Molecular weight:801.84

    Ref: TM-T78697

  • Keap1-Nrf2-IN-16
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    Keap1-Nrf2-IN-16

    CAS:
    <p>Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.</p>
    Formula:C73H114N16O26
    Color and Shape:Solid
    Molecular weight:1631.78

    Ref: TM-T80260

  • Keap1-Nrf2-IN-6
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    Keap1-Nrf2-IN-6

    <p>Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM</p>
    Formula:C30H34N4O8S
    Color and Shape:Solid
    Molecular weight:610.68

    Ref: TM-T72760

  • Nrf2-IN-1
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    Nrf2-IN-1

    CAS:
    <p>Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).</p>
    Formula:C21H22ClN3O2
    Purity:95.00% - 99.68%
    Color and Shape:Solid
    Molecular weight:383.87

    Ref: TM-T12253

  • Nrf2 activator-7
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    Nrf2 activator-7

    CAS:
    <p>Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.</p>
    Formula:C35H32N2O11S2
    Color and Shape:Solid
    Molecular weight:720.77

    Ref: TM-T78696

  • Nrf2-IN-3
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    Nrf2-IN-3

    CAS:
    <p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>
    Formula:C22H26N4O4S
    Purity:98.07%
    Color and Shape:Solid
    Molecular weight:442.53

    Ref: TM-T78841

  • CPDT
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    CPDT

    CAS:
    <p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>
    Formula:C6H6S3
    Color and Shape:Solid
    Molecular weight:174.307

    Ref: TM-T204763

  • CymitQuimica logo
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    Nrf2 activator-2

    <p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>
    Formula:C20H17BrO3
    Color and Shape:Solid
    Molecular weight:385.25

    Ref: TM-T61688

  • Nrf2 activator-6
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    Nrf2 activator-6

    CAS:
    <p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>
    Formula:C31H37ClFN5O5
    Color and Shape:Solid
    Molecular weight:614.11

    Ref: TM-T72697

  • Keap1-Nrf2-IN-5
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    Keap1-Nrf2-IN-5

    CAS:
    <p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>
    Formula:C23H30N4O6S
    Color and Shape:Solid
    Molecular weight:490.57

    Ref: TM-T63294

  • VVD-130037
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    VVD-130037

    CAS:
    <p>VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.</p>
    Formula:C17H17ClN4O2
    Purity:99.01% - 99.92%
    Color and Shape:Solid
    Molecular weight:344.8

    Ref: TM-T88838

  • KI696
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    KI696

    CAS:
    <p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>
    Formula:C28H30N4O6S
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:550.63

    Ref: TM-T11758L

  • NSC23925
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    NSC23925

    CAS:
    NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
    Formula:C22H26Cl2N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:421.36

    Ref: TM-T16352

    1mg
    Discontinued
    Discontinued product