Nrf2
Nrf2 is a transcription factor that regulates the expression of antioxidant proteins and detoxification enzymes, playing a pivotal role in cellular defense against oxidative stress and inflammation. Activation of Nrf2 signaling provides protection against various diseases, including cancer, neurodegeneration, and cardiovascular disorders. Nrf2 modulators are being explored for their potential therapeutic applications in reducing oxidative damage and inflammation. At CymitQuimica, we provide a range of high-quality Nrf2 pathway modulators to support your research in oxidative stress, inflammation, and disease prevention.
Found 82 products of "Nrf2"
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(+)-DHMEQ
CAS:(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.Formula:C13H11NO5Color and Shape:SolidMolecular weight:261.23AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFormula:C11H13ClO3S2Purity:98%Color and Shape:SolidMolecular weight:292.8MSU38225
CAS:MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.Formula:C21H19N3Color and Shape:SolidMolecular weight:313.4Nrf2-Activator-12G
CAS:Nrf2-Activator-12G is a potent Nrf-2 activator.Formula:C15H13ClO3SPurity:98%Color and Shape:SolidMolecular weight:308.78WN1316
CAS:WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Formula:C20H26Cl3N5OColor and Shape:SolidMolecular weight:458.81Nrf2 activator-5
CAS:Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.Formula:C25H30Cl2O6Color and Shape:SolidMolecular weight:497.41Keap1-Nrf2-IN-14
CAS:Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Formula:C30H29NO8SColor and Shape:SolidMolecular weight:563.62Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Formula:C8H16O2S2Purity:97.51%Color and Shape:Yellow To Orange LiquidMolecular weight:208.34Nrf2 activator-4
CAS:Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.Formula:C23H24ClF3N2O3Purity:98.53%Color and Shape:SolidMolecular weight:468.9Stigmane B
Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.Formula:C21H30O4Color and Shape:SolidMolecular weight:346.46K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Formula:C29H30N2O7S2Purity:98.43%Color and Shape:SolidMolecular weight:582.69Keap1-Nrf2-IN-12
CAS:eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.Formula:C26H28N2O10S2Color and Shape:SolidMolecular weight:592.64Keap1-Nrf2-IN-13
CAS:Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.Formula:C28H32N2O10S2Color and Shape:SolidMolecular weight:620.69MIND4-17
CAS:MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.Formula:C20H15N5O3SColor and Shape:SolidMolecular weight:405.43SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Formula:C18H23NO4Purity:98%Color and Shape:SolidMolecular weight:317.38NXPZ-2
CAS:NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.Formula:C27H27N5O7S2Color and Shape:SolidMolecular weight:597.66CDDO-EA
CAS:CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Formula:C33H46N2O3Purity:99.66%Color and Shape:SolidMolecular weight:518.73Ref: TM-T10733
1mg85.00€5mg169.00€10mg298.00€25mg512.00€50mg732.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)187.00€DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Formula:C14H9F2N3OPurity:99.85%Color and Shape:SolidMolecular weight:273.24WRR139
CAS:WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1Formula:C25H32N2O4SColor and Shape:SolidMolecular weight:456.6Keap1-Nrf2-IN-6
Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nMFormula:C30H34N4O8SColor and Shape:SolidMolecular weight:610.68Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFormula:C39H35N3O12S2Color and Shape:SolidMolecular weight:801.84Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Formula:C73H114N16O26Color and Shape:SolidMolecular weight:1631.78Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Formula:C35H32N2O11S2Color and Shape:SolidMolecular weight:720.77Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Formula:C21H22ClN3O2Purity:95.00% - 99.68%Color and Shape:SolidMolecular weight:383.87Ref: TM-T12253
1mg74.00€2mg97.00€5mg160.00€10mg219.00€25mg364.00€50mg512.00€100mg727.00€200mg938.00€1mL*10mM (DMSO)301.00€Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Formula:C22H26N4O4SPurity:98.07%Color and Shape:SolidMolecular weight:442.53Ref: TM-T78841
1mg62.00€5mg133.00€10mg207.00€25mg393.00€50mg540.00€100mg747.00€200mg1,074.00€1mL*10mM (DMSO)145.00€Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formula:C31H37ClFN5O5Color and Shape:SolidMolecular weight:614.11Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formula:C23H30N4O6SColor and Shape:SolidMolecular weight:490.57CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formula:C6H6S3Color and Shape:SolidMolecular weight:174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formula:C20H17BrO3Color and Shape:SolidMolecular weight:385.25VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formula:C17H17ClN4O2Purity:99.01% - 99.92%Color and Shape:SolidMolecular weight:344.8Ref: TM-T88838
1mg141.00€5mg339.00€10mg494.00€25mg789.00€50mg1,046.00€100mg1,429.00€1mL*10mM (DMSO)370.00€KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formula:C28H30N4O6SPurity:99.74%Color and Shape:SolidMolecular weight:550.63Ref: TM-T11758L
1mg144.00€5mg298.00€10mg445.00€25mg747.00€50mg1,074.00€100mg1,549.00€200mg2,072.00€1mL*10mM (DMSO)360.00€NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formula:C22H26Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:421.36
