TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
Found 58 products of "TGF-beta/Smad"
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Oxymatrine
CAS:<p>Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.</p>Formula:C15H24N2O2Purity:98.72% - 99.72%Color and Shape:SolidMolecular weight:264.36Garetosmab
CAS:<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:146 kDaPonsegromab
CAS:<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Purity:100% (SEC-HPLC) - > 95%Color and Shape:LiquidMolecular weight:146.08 kDaIsoviolanthin
CAS:<p>Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.</p>Formula:C27H30O14Purity:99.25% - 99.66%Color and Shape:SolidMolecular weight:578.52Hydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formula:C7H8ClN3O4S2Purity:99.43% - 99.50%Color and Shape:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Molecular weight:297.74Rilogrotug
<p>Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Color and Shape:Odour LiquidALK5-IN-83
<p>ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.</p>Formula:C20H23N7O2SColor and Shape:SolidMolecular weight:425.51SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:<p>SLLK is a control peptide for LSKL.</p>Formula:C21H41N5O6Purity:98%Color and Shape:SolidMolecular weight:459.58TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.582CBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Formula:C18H20ClN3OColor and Shape:SolidMolecular weight:329.82Cirevetmab
CAS:<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Color and Shape:LiquidTubastatin
CAS:<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Formula:C21H22N2O2Purity:98.23%Color and Shape:SolidMolecular weight:334.41Sotatercept
CAS:<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Purity:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Color and Shape:LiquidEmugrobart
<p>Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Color and Shape:Odour LiquidFresolimumab
CAS:<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:144.4 kDaLinavonkibart
CAS:<p>Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.</p>Purity:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidLerdelimumab
CAS:<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Color and Shape:LiquidBintrafusp alfa
CAS:<p>Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.</p>Purity:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Color and Shape:LiquidITD-1
CAS:<p>ITD-1 is a potent and highly selective TGFβ pathway inhibitor.</p>Formula:C27H29NO3Purity:99.89% - >99.99%Color and Shape:SolidMolecular weight:415.52Kartogenin
CAS:<p>Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.</p>Formula:C20H15NO3Purity:96.25% - 97.79%Color and Shape:SolidMolecular weight:317.34
