TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
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Isoviolanthin
CAS:40788-84-9
Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal …
Formula:
C27H30O14
Purity:
99.25% - 99.61%
Color and Shape:
Solid
Molecular weight:
578.52
Ref: TM-T13741
| 1mg | 92.00 € | ||
| 2mg | 131.00 € | ||
| 5mg | 187.00 € | ||
| 10mg | 354.00 € | ||
| 25mg | 597.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 283.00 € |
Estimated delivery in United States, on Wednesday 9 Apr 2025
Hydrochlorothiazide
CAS:58-93-5
Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药,可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能,减少纤维化并具有降压作用。
Formula:
C7H8ClN3O4S2
Purity:
99.43% - 99.50%
Color and Shape:
Crystals Physical Description Crystals Or White Powder (Ntp 1992)
Molecular weight:
297.74
Ref: TM-T1449
| 50mg | 34.00 € |
Estimated delivery in United States, on Wednesday 9 Apr 2025
Oxymatrine
CAS:16837-52-8
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.
Formula:
C15H24N2O2
Purity:
99.72%
Color and Shape:
Solid
Molecular weight:
264.36
Ref: TM-T2754
| 1g | 170.00 € | ||
| 50mg | 48.00 € | ||
| 100mg | 65.00 € | ||
| 200mg | 87.00 € | ||
| 500mg | 126.00 € | ||
| 1mL*10mM (DMSO) | 71.00 € |
Estimated delivery in United States, on Wednesday 9 Apr 2025
Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as …
Ref: TM-T9901A-440
| 1mg | To inquire | ||
| 5mg | To inquire |
Estimated delivery in United States, on Thursday 10 Apr 2025
ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses …
Formula:
C20H23N7O2S
Color and Shape:
Liquid
Molecular weight:
425.51
Ref: TM-T201033
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 10 Apr 2025
Tubastatin
CAS:1239034-70-8
Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.
Formula:
C21H22N2O2
Purity:
98.23%
Color and Shape:
Solid
Molecular weight:
334.41
Ref: TM-T29023
| 1mg | 48.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 130.00 € | ||
| 25mg | 208.00 € | ||
| 50mg | 311.00 € | ||
| 100mg | 465.00 € | ||
| 500mg | 1,035.00 € |
Estimated delivery in United States, on Thursday 10 Apr 2025
CBT-295
CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and …
Formula:
C18H20ClN3O
Color and Shape:
Liquid
Molecular weight:
329.82
Ref: TM-T89861
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 10 Apr 2025
Rilogrotug
Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being …
Ref: TM-T9901A-392
| 1mg | To inquire | ||
| 5mg | To inquire |
Estimated delivery in United States, on Thursday 10 Apr 2025
ITD-1
CAS:1099644-42-4
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
Formula:
C27H29NO3
Purity:
100% - 99.89%
Color and Shape:
Solid
Molecular weight:
415.52
Ref: TM-T2273
| 2mg | 39.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 124.00 € | ||
| 50mg | 166.00 € | ||
| 100mg | 248.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
Galunisertib
CAS:700874-72-2
Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. …
Formula:
C22H19N5O
Purity:
97.09% - 99.98%
Color and Shape:
Solid
Molecular weight:
369.42
Ref: TM-T2510
| 1g | 692.00 € | ||
| 5mg | 48.00 € | ||
| 10mg | 55.00 € | ||
| 25mg | 88.00 € | ||
| 50mg | 120.00 € | ||
| 100mg | 188.00 € | ||
| 200mg | 284.00 € | ||
| 500mg | 467.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
Alantolactone
CAS:546-43-0
Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective …
Formula:
C15H20O2
Purity:
99.02% - 99.91%
Color and Shape:
Crystalline Powder
Molecular weight:
232.32
Ref: TM-T2896
| 5mg | 55.00 € | ||
| 10mg | 71.00 € | ||
| 25mg | 141.00 € | ||
| 50mg | 221.00 € | ||
| 100mg | 399.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
BMP signaling agonist sb4
CAS:100874-08-6
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) …
Formula:
C14H10BrNOS
Purity:
99.48% - 99.94%
Color and Shape:
Solid
Molecular weight:
320.2
Ref: TM-T7799
| 5mg | 47.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 88.00 € | ||
| 50mg | 126.00 € | ||
| 100mg | 187.00 € | ||
| 200mg | 283.00 € | ||
| 500mg | 490.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
BMS986260
CAS:2001559-19-7
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
Formula:
C18H12ClFN6O
Purity:
97.67%
Color and Shape:
Solid
Molecular weight:
382.78
Ref: TM-T8730
| 1mg | 88.00 € | ||
| 5mg | 160.00 € | ||
| 10mg | 230.00 € | ||
| 25mg | 378.00 € | ||
| 50mg | 568.00 € | ||
| 100mg | 805.00 € | ||
| 1mL*10mM (DMSO) | 188.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
BIO-013077-01
CAS:746667-48-1
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
Formula:
C17H13N5
Purity:
99.87%
Color and Shape:
Solid
Molecular weight:
287.32
Ref: TM-T8330
| 1mg | 50.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 140.00 € | ||
| 25mg | 273.00 € | ||
| 50mg | 393.00 € | ||
| 100mg | 557.00 € | ||
| 200mg | 753.00 € | ||
| 1mL*10mM (DMSO) | 138.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
SRI-011381 hydrochloride
CAS:2070014-88-7
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment …
Formula:
C20H32ClN3O
Purity:
98.24% - 99.59%
Color and Shape:
Solid
Molecular weight:
365.94
Ref: TM-T5129
| 2mg | 47.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 227.00 € | ||
| 50mg | 378.00 € | ||
| 100mg | 560.00 € | ||
| 500mg | 1,216.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
SD-208
CAS:627536-09-8
SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity …
Formula:
C17H10ClFN6
Purity:
98.72% - 99.65%
Color and Shape:
Solid
Molecular weight:
352.75
Ref: TM-T2109
| 1mg | 40.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 101.00 € | ||
| 25mg | 205.00 € | ||
| 50mg | 310.00 € | ||
| 100mg | 485.00 € | ||
| 1mL*10mM (DMSO) | 111.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
Trimethylamine N-oxide dihydrate
CAS:62637-93-8
TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.
Formula:
C3H13NO3
Purity:
98%
Color and Shape:
White Crystal
Molecular weight:
111.14
Ref: TM-T5247
| 1g | 48.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
LY3200882
CAS:1898283-02-7
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
Formula:
C24H29N5O3
Purity:
98.37% - 99.46%
Color and Shape:
Solid
Molecular weight:
435.52
Ref: TM-T5125
| 1mg | 47.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 144.00 € | ||
| 25mg | 274.00 € | ||
| 50mg | 432.00 € | ||
| 100mg | 655.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
Asiaticoside
CAS:16830-15-2
Asiaticoside, in Centella asiatica, may treat wounds/burns.
Formula:
C48H78O19
Purity:
98% - 99.96%
Color and Shape:
Powder
Molecular weight:
959.12
Ref: TM-T3025
| 20mg | 55.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
Chebulinic acid
CAS:18942-26-2
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit …
Formula:
C41H32O27
Purity:
98.4% - 99.54%
Color and Shape:
Solid
Molecular weight:
956.68
Ref: TM-TQ0184
| 1mg | 73.00 € | ||
| 5mg | 155.00 € | ||
| 10mg | 219.00 € | ||
| 25mg | 465.00 € | ||
| 50mg | 692.00 € | ||
| 100mg | 938.00 € | ||
| 500mg | 1,882.00 € | ||
| 1mL*10mM (DMSO) | 266.00 € |
Estimated delivery in United States, on Wednesday 16 Apr 2025
