TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
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Isoviolanthin
CAS:40788-84-9
Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal …
Formula:
C27H30O14
Purity:
99.25% - 99.61%
Color and Shape:
Solid
Molecular weight:
578.52
Ref: TM-T13741
| 1mg | 90.00 € | ||
| 2mg | 128.00 € | ||
| 5mg | 183.00 € | ||
| 10mg | 347.00 € | ||
| 25mg | 587.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 281.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Hydrochlorothiazide
CAS:58-93-5
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of …
Formula:
C7H8ClN3O4S2
Purity:
99.43% - 99.9%
Color and Shape:
Crystals Physical Description Crystals Or White Powder (Ntp 1992)
Molecular weight:
297.74
Ref: TM-T1449
| 500mg | 51.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Oxymatrine
CAS:16837-52-8
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.
Formula:
C15H24N2O2
Purity:
99.84%
Color and Shape:
Solid
Molecular weight:
264.36
Ref: TM-T2754
| 1g | 171.00 € | ||
| 50mg | 48.00 € | ||
| 100mg | 64.00 € | ||
| 200mg | 96.00 € | ||
| 500mg | 123.00 € | ||
| 1mL*10mM (DMSO) | 71.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Sotatercept
CAS:1001080-50-7
Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.
Color and Shape:
Liquid
Ref: TM-T76995
| 1mg | 541.00 € | ||
| 5mg | 1,382.00 € | ||
| 10mg | 2,231.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Tubastatin
CAS:1239034-70-8
Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.
Formula:
C21H22N2O2
Purity:
98.23%
Color and Shape:
Solid
Molecular weight:
334.41
Ref: TM-T29023
| 1mg | 47.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 127.00 € | ||
| 25mg | 204.00 € | ||
| 50mg | 305.00 € | ||
| 100mg | 454.00 € | ||
| 500mg | 1,012.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
CBT-295
CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and …
Formula:
C18H20ClN3O
Color and Shape:
Liquid
Molecular weight:
329.82
Ref: TM-T89861
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
P17 Peptide
CAS:846546-36-9
P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.
Formula:
C95H139N27O21
Color and Shape:
Liquid
Molecular weight:
1995.29
Ref: TM-TP2844
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Kartogenin
CAS:4727-31-5
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of …
Formula:
C20H15NO3
Purity:
96.25% - 97.79%
Color and Shape:
Solid
Molecular weight:
317.34
Ref: TM-T1748
| 2mg | 40.00 € | ||
| 5mg | 55.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 166.00 € | ||
| 100mg | 274.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
ITD-1
CAS:1099644-42-4
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
Formula:
C27H29NO3
Purity:
100% - 99.89%
Color and Shape:
Solid
Molecular weight:
415.52
Ref: TM-T2273
| 2mg | 39.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 163.00 € | ||
| 100mg | 244.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Galunisertib
CAS:700874-72-2
Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. …
Formula:
C22H19N5O
Purity:
100% - 99.98%
Color and Shape:
Solid
Molecular weight:
369.42
Ref: TM-T2510
| 1g | 677.00 € | ||
| 5mg | 47.00 € | ||
| 10mg | 54.00 € | ||
| 25mg | 87.00 € | ||
| 50mg | 119.00 € | ||
| 100mg | 184.00 € | ||
| 200mg | 279.00 € | ||
| 500mg | 456.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Alantolactone
CAS:546-43-0
Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective …
Formula:
C15H20O2
Purity:
99.02% - 99.91%
Color and Shape:
Crystalline Powder
Molecular weight:
232.32
Ref: TM-T2896
| 5mg | 54.00 € | ||
| 10mg | 70.00 € | ||
| 25mg | 139.00 € | ||
| 50mg | 217.00 € | ||
| 100mg | 390.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
R-268712
CAS:879487-87-3
R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type …
Formula:
C20H18FN5O
Purity:
99.77%
Color and Shape:
Solid
Molecular weight:
363.39
Ref: TM-T16708
| 1mg | 46.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 135.00 € | ||
| 25mg | 261.00 € | ||
| 50mg | 393.00 € | ||
| 100mg | 559.00 € | ||
| 200mg | 795.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SRI-011381 hydrochloride
CAS:2070014-88-7
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment …
Formula:
C20H32ClN3O
Purity:
98% - 99.59%
Color and Shape:
Solid
Molecular weight:
365.94
Ref: TM-T5129
| 2mg | 46.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 223.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 547.00 € | ||
| 500mg | 1,196.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Asiaticoside
CAS:16830-15-2
Asiaticoside, in Centella asiatica, may treat wounds/burns.
Formula:
C48H78O19
Purity:
98% - 99.71%
Color and Shape:
Powder
Molecular weight:
959.12
Ref: TM-T3025
| 20mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Chebulinic acid
CAS:18942-26-2
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit …
Formula:
C41H32O27
Purity:
98.4% - 98.91%
Color and Shape:
Solid
Molecular weight:
956.68
Ref: TM-TQ0184
| 1mg | 73.00 € | ||
| 5mg | 151.00 € | ||
| 10mg | 214.00 € | ||
| 25mg | 457.00 € | ||
| 50mg | 676.00 € | ||
| 100mg | 916.00 € | ||
| 500mg | 1,839.00 € | ||
| 1mL*10mM (DMSO) | 265.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
(E)-SIS3
CAS:521984-48-5
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding
Formula:
C28H27N3O3·HCl
Purity:
95.64% - 98.83%
Color and Shape:
Solid
Molecular weight:
489.99
Ref: TM-T3636
| 1mg | 42.00 € | ||
| 2mg | 56.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 170.00 € | ||
| 25mg | 337.00 € | ||
| 50mg | 502.00 € | ||
| 100mg | 716.00 € | ||
| 500mg | 1,439.00 € | ||
| 1mL*10mM (DMSO) | 121.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SJ000291942
CAS:425613-09-8
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
Formula:
C16H15FN2O4
Purity:
99.07%
Color and Shape:
Solid
Molecular weight:
318.3
Ref: TM-T4662
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 227.00 € | ||
| 50mg | 393.00 € | ||
| 100mg | 582.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
Formula:
C25H44F6N6O9
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
686.64
Ref: TM-T7676
| 2mg | 43.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 212.00 € | ||
| 100mg | 326.00 € | ||
| 200mg | 455.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
BMP signaling agonist sb4
CAS:100874-08-6
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) …
Formula:
C14H10BrNOS
Purity:
99.48% - 99.94%
Color and Shape:
Solid
Molecular weight:
320.2
Ref: TM-T7799
| 5mg | 46.00 € | ||
| 10mg | 59.00 € | ||
| 25mg | 87.00 € | ||
| 50mg | 124.00 € | ||
| 100mg | 184.00 € | ||
| 200mg | 276.00 € | ||
| 500mg | 479.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
BMS986260
CAS:2001559-19-7
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
Formula:
C18H12ClFN6O
Purity:
97.67%
Color and Shape:
Solid
Molecular weight:
382.78
Ref: TM-T8730
| 1mg | 87.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 228.00 € | ||
| 25mg | 373.00 € | ||
| 50mg | 561.00 € | ||
| 100mg | 796.00 € | ||
| 1mL*10mM (DMSO) | 186.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
