TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
Found 58 products of "TGF-beta/Smad"
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Halofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formula:C16H17BrClN3O3Purity:99.53%Color and Shape:Off-White SolidMolecular weight:414.68Chromenone 1
CAS:<p>Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).</p>Formula:C18H10F3N3O2Purity:99.83% - 99.93%Color and Shape:SolidMolecular weight:357.29Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formula:C16H17BrClN3O3·HBrPurity:97.01% - 99.73%Color and Shape:SolidMolecular weight:495.59CJJ300
CAS:<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Formula:C30H33N3Purity:99.80%Color and Shape:SolidMolecular weight:435.6(Rac)-SIS3 free base
CAS:<p>SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.</p>Formula:C28H27N3O3Purity:98%Color and Shape:SolidMolecular weight:453.53TGFβRI-IN-1
CAS:<p>TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,</p>Formula:C20H14D3N5O2Purity:98%Color and Shape:SolidMolecular weight:362.4SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Formula:C14H14ClFN2O2Purity:99.94%Color and Shape:SolidMolecular weight:296.723,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formula:C17H14O4Purity:98%Color and Shape:SolidMolecular weight:282.29DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Formula:C89H130N20O29S2Purity:98%Color and Shape:SolidMolecular weight:2008.23TGFβ-IN-5
CAS:<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Formula:C20H16N4Purity:99.29% - 99.5%Color and Shape:SolidMolecular weight:312.37Myristoyl tetrapeptide-12
CAS:<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Formula:C32H63N7O5Purity:98%Color and Shape:SolidMolecular weight:625.89TP0427736
CAS:<p>TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.</p>Formula:C14H10N4S2Purity:97.26%Color and Shape:SolidMolecular weight:298.39(+)-ITD-1
CAS:<p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>Formula:C27H29NO3Color and Shape:SolidMolecular weight:415.52CDD-1431
CAS:<p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Formula:C33H38N8O5SColor and Shape:SolidMolecular weight:658.77TGFβ1-IN-1
CAS:<p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>Formula:C22H24N2O3Purity:99.89% - 99.89%Color and Shape:SolidMolecular weight:364.438TGFβRI-IN-3
CAS:<p>TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.</p>Formula:C28H23N3O2SPurity:99.85%Color and Shape:SoildMolecular weight:465.57Luspatercept
CAS:<p>Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].</p>Color and Shape:LiquidDCN1-IN-2
CAS:<p>DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.</p>Formula:C18H14ClF3N4OSColor and Shape:SolidMolecular weight:426.84
