TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
Found 70 products for "TGF-beta/Smad".
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Sotatercept
CAS:Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.Purity:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Color and Shape:Transparent LiquidMolecular weight:38.94 kDaLinavonkibart
CAS:Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.Purity:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.68 kDaDepiperazine-DM3189
CAS:Depiperazine-DM3189 inhibits the phosphorylation of SMAD 1/5/8 induced by bone morphogenetic protein 4 and can be used in biochemical experiments .Formula:C21H14N4Purity:99.69%Molecular weight:322.36Bintrafusp alfa
CAS:Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.Purity:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Color and Shape:LiquidMolecular weight:177.25 kDaSRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formula:C20H31N3OPurity:98.64%Color and Shape:SolidMolecular weight:329.48SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formula:C20H32ClN3OPurity:99.32% - 99.41%Color and Shape:SolidMolecular weight:365.94Ref: TM-T5129
1mg34.00€2mg44.00€5mg66.00€1mL*10mM (DMSO)73.00€10mg105.00€25mg215.00€50mg334.00€100mg497.00€200mg755.00€Asiaticoside
CAS:Asiaticoside, in Centella asiatica, may treat wounds/burns.Formula:C48H78O19Purity:98% - 99.96%Color and Shape:Red SolidMolecular weight:959.12Chebulinic acid
CAS:Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Formula:C41H32O27Purity:98.91% - 99.71%Color and Shape:SolidMolecular weight:956.68Ref: TM-TQ0184
1mg66.00€5mg145.00€10mg203.00€1mL*10mM (DMSO)215.00€25mg409.00€50mg595.00€100mg833.00€(E)-SIS3
CAS:(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!Formula:C28H27N3O3·HClPurity:95.64% - 98%Color and Shape:Yellow SolidMolecular weight:489.99Ref: TM-T3636
1mg40.00€2mg54.00€5mg105.00€1mL*10mM (DMSO)114.00€10mg164.00€25mg326.00€50mg485.00€100mg692.00€500mg1,395.00€R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurity:99.61%Color and Shape:SolidMolecular weight:363.39Ref: TM-T16708
1mg44.00€1mL*10mM (DMSO)92.00€5mg93.00€10mg130.00€25mg250.00€50mg378.00€100mg537.00€200mg762.00€SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Formula:C16H15FN2O4Purity:99.66%Color and Shape:SolidMolecular weight:318.3Ref: TM-T4662
1mg34.00€2mg44.00€5mg63.00€1mL*10mM (DMSO)71.00€10mg100.00€25mg205.00€50mg349.00€100mg557.00€200mg790.00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formula:C25H44F6N6O9Purity:99.75%Color and Shape:SolidMolecular weight:686.64Ref: TM-T7676
2mg42.00€5mg54.00€10mg84.00€1mL*10mM (DMSO)93.00€25mg138.00€50mg207.00€100mg316.00€200mg442.00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formula:C20H15NO3Purity:96.25% - 98%Color and Shape:White SolidMolecular weight:317.34ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formula:C27H29NO3Purity:99.89% - >99.99%Color and Shape:Yellow SolidMolecular weight:415.52Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formula:C22H19N5OPurity:97.09% - 99.98%Color and Shape:White SolidMolecular weight:369.42Ref: TM-T2510
5mg46.00€10mg52.00€1mL*10mM (DMSO)52.00€25mg84.00€50mg114.00€100mg178.00€200mg269.00€500mg442.00€1g657.00€Alantolactone
CAS:Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.Formula:C15H20O2Purity:99.02% - 99.66%Color and Shape:SolidMolecular weight:232.32BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formula:C14H10BrNOSPurity:99.48% - 99.80%Color and Shape:SolidMolecular weight:320.2Ref: TM-T7799
5mg44.00€1mL*10mM (DMSO)48.00€10mg57.00€25mg94.00€50mg119.00€100mg177.00€200mg268.00€500mg465.00€BMS986260
CAS:BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Formula:C18H12ClFN6OPurity:97.67%Color and Shape:SolidMolecular weight:382.78BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formula:C17H13N5Purity:99.87%Color and Shape:SolidMolecular weight:287.32Ref: TM-T8330
1mg48.00€5mg96.00€1mL*10mM (DMSO)131.00€10mg133.00€25mg259.00€50mg371.00€100mg527.00€200mg713.00€Trimethylamine N-oxide dihydrate
CAS:TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.Formula:C3H13NO3Purity:98.75%Color and Shape:White CrystalMolecular weight:111.14
