TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
Found 58 products of "TGF-beta/Smad"
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Asiaticoside
CAS:<p>Asiaticoside, in Centella asiatica, may treat wounds/burns.</p>Formula:C48H78O19Purity:98% - 99.96%Color and Shape:PowderMolecular weight:959.12Chebulinic acid
CAS:<p>Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.</p>Formula:C41H32O27Purity:98.91% - 99.71%Color and Shape:SolidMolecular weight:956.68(E)-SIS3
CAS:<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Formula:C28H27N3O3·HClPurity:95.64% - 98%Color and Shape:SolidMolecular weight:489.99R-268712
CAS:<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Formula:C20H18FN5OPurity:99.61%Color and Shape:SolidMolecular weight:363.39SJ000291942
CAS:<p>SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.</p>Formula:C16H15FN2O4Purity:99.66%Color and Shape:SolidMolecular weight:318.3LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formula:C25H44F6N6O9Purity:99.75%Color and Shape:SolidMolecular weight:686.64Kartogenin
CAS:<p>Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.</p>Formula:C20H15NO3Purity:96.25% - 97.79%Color and Shape:SolidMolecular weight:317.34ITD-1
CAS:<p>ITD-1 is a potent and highly selective TGFβ pathway inhibitor.</p>Formula:C27H29NO3Purity:99.89% - >99.99%Color and Shape:SolidMolecular weight:415.52Galunisertib
CAS:<p>Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C22H19N5OPurity:97.09% - 99.98%Color and Shape:SolidMolecular weight:369.42Alantolactone
CAS:<p>Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.</p>Formula:C15H20O2Purity:99.02% - 99.66%Color and Shape:Crystalline PowderMolecular weight:232.32BMP signaling agonist sb4
CAS:<p>BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)</p>Formula:C14H10BrNOSPurity:99.48% - 99.805%Color and Shape:SolidMolecular weight:320.2BMS986260
CAS:<p>BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).</p>Formula:C18H12ClFN6OPurity:97.67%Color and Shape:SolidMolecular weight:382.78BIO-013077-01
CAS:<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Formula:C17H13N5Purity:99.87%Color and Shape:SolidMolecular weight:287.32Trimethylamine N-oxide dihydrate
CAS:<p>TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.</p>Formula:C3H13NO3Purity:98.75%Color and Shape:White CrystalMolecular weight:111.14LY3200882
CAS:<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Formula:C24H29N5O3Purity:99.46% - 99.63%Color and Shape:SolidMolecular weight:435.52SRI-011381
CAS:<p>SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formula:C20H31N3OPurity:98.64%Color and Shape:SolidMolecular weight:329.48Trevogrumab
CAS:<p>Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).</p>Purity:95% - 95%Color and Shape:LiquidNisevokitug
CAS:<p>Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.</p>Purity:95%Color and Shape:LiquidMetelimumab
CAS:<p>Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).</p>Purity:95%Color and Shape:LiquidLivmoniplimab
CAS:<p>Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32</p>Purity:95%Color and Shape:Liquid
