MALT
Mucosa-associated lymphoid tissue (MALT) is an essential component of the immune system that protects mucosal surfaces from pathogens. MALT includes structures such as the tonsils, Peyer's patches, and the appendix, which are involved in the initiation of immune responses to antigens encountered at mucosal surfaces. Research on MALT is critical for understanding the mechanisms of mucosal immunity and the development of vaccines and treatments for mucosal infections. At CymitQuimica, we provide a range of reagents and tools to support your research in mucosal immunology, inflammation, and infectious diseases.
Found 23 products of "MALT"
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MLT-231
<p>MLT-231: potent MALT1 Inhibitor, IC50=9 nM; blocks BCL10 cleavage, IC50=160 nM; exhibits antitumor efficacy in mouse ABC-DLBCL model.</p>Color and Shape:SolidMLT-985
CAS:<p>MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC 50 value of 3 nM.</p>Formula:C17H15Cl2N9O2Color and Shape:SolidMolecular weight:448.27MALT1 inhibitor MI-2
CAS:<p>MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.</p>Formula:C19H17Cl3N4O3Purity:98% - 99.87%Color and Shape:SolidMolecular weight:455.72Cladribine
CAS:<p>Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.</p>Formula:C10H12ClN5O3Purity:99.58% - >99.99%Color and Shape:White Crystalline SolidMolecular weight:285.69MLT-943
CAS:<p>MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].</p>Formula:C16H14ClF3N6O2Purity:99.72% - 99.82%Color and Shape:SolidMolecular weight:414.77MLT-748
CAS:<p>MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).</p>Formula:C19H19Cl2N9O3Purity:99.62%Color and Shape:SolidMolecular weight:492.32(R)-MLT-985
CAS:<p>(R)-MLT-985 (compound 11) is a MALT1 protease inhibitor with IC50 of 3 nM, also blocking IL-2 in Jurkat cells and ABC-DLBCL cell growth.</p>Formula:C17H15Cl2N9O2Color and Shape:SolidMolecular weight:448.27MALT1-IN-3
CAS:<p>MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.</p>Formula:C21H19F3N8O2Color and Shape:SolidMolecular weight:472.42MALT1-IN-8
CAS:<p>MALT1-IN-8: potent MALT1 inhibitor, IC50=2 nM; hinders OCI-LY3 cells, IC50=1.16 μM; anticancer, from patent WO2018165385A1.</p>Formula:C20H15Cl2N7OColor and Shape:SolidMolecular weight:440.29MLT-747
CAS:<p>MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).</p>Formula:C20H21Cl2N7O3Color and Shape:SolidMolecular weight:478.33Z-VRPR-FMK
CAS:<p>Z-VRPR-FMK: irreversible MALT1 inhibitor, halts growth/invasion of diffused B-cell lymphoma by blocking NF-κB activation and MMP expression.</p>Formula:C31H49FN10O6Color and Shape:SolidMolecular weight:676.78(R)-MALT1-IN-3
CAS:<p>(R)-MALT1-IN-3 (121) inhibits MALT1 protease (IC50: 20 nM) and IL6/IL10 in OCI-LY3 (IC50: 60/40 nM).</p>Formula:C21H19F3N8O2Color and Shape:SolidMolecular weight:472.42JNJ-67856633
CAS:<p>JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease .</p>Formula:C20H11F6N5O2Purity:99.87%Color and Shape:SolidMolecular weight:467.32(R)-MALT1-IN-7
CAS:<p>(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.</p>Formula:C19H17F3N8O2SColor and Shape:SolidMolecular weight:478.45MALT1-IN-9
CAS:<p>MALT1-IN-9: potent MALT1 protease inhibitor, IC50 <500 nM in Raji cells, significant anticancer effects.</p>Formula:C16H12ClF3N6OColor and Shape:SolidMolecular weight:396.75NVS-MALT1
CAS:<p>NVS-MALT1 is an allosteric inhibitor of MALT1 [1].</p>Formula:C24H27ClF3N5O4SColor and Shape:SolidMolecular weight:574.02MALT1-IN-7
CAS:<p>MALT1-IN-7 (compound 142b) is a potent inhibitor of MALT1 protease with potential for cancer research.</p>Formula:C19H17F3N8O2SColor and Shape:SolidMolecular weight:478.45MALT1-IN-6
CAS:<p>MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.</p>Formula:C18H12Cl2F3N9OColor and Shape:SolidMolecular weight:498.25RGT-068A
CAS:<p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>Formula:C17H16ClN9O2Color and Shape:SolidMolecular weight:413.82MALT1-IN-11
CAS:<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Formula:C20H16F4N8OColor and Shape:SolidMolecular weight:460.39(S,R,S)-AHPC-Boc derivative 1
CAS:<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Formula:C28H40N4O6SColor and Shape:SolidMolecular weight:560.705MALT1-IN-5
CAS:<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Formula:C17H17ClF2N6O3Color and Shape:SolidMolecular weight:426.80(S)-MALT1-IN-5
CAS:<p>(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.</p>Formula:C17H17ClF2N6O3Color and Shape:SolidMolecular weight:426.80
