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Pim

Pim

Pim kinases are a family of serine/threonine kinases that play a key role in cell survival, proliferation, and apoptosis. These kinases are downstream effectors in the JAK/STAT signaling pathway and are involved in various physiological processes, including immune responses and hematopoiesis. Overexpression of Pim kinases has been associated with the development of cancer, making them important targets for therapeutic intervention. At CymitQuimica, we offer a variety of high-quality Pim kinase inhibitors and modulators to support your research in oncology, cell biology, and signal transduction.

Found 32 products of "Pim"

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  • AZD-1897
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    AZD-1897

    CAS:
    AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.
    Formula:C18H23N3O3S
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:361.46

    Ref: TM-T71242

  • M-110
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    M-110

    CAS:
    M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).
    Formula:C22H28ClN5O3
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:445.94

    Ref: TM-T15830

  • PIM-1 Inhibitor 2
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    PIM-1 Inhibitor 2

    CAS:
    PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.
    Formula:C17H11ClN4O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:322.75

    Ref: TM-T23158

  • FD1024
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    FD1024

    CAS:
    <p>FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.</p>
    Formula:C21H20F2N4O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.47

    Ref: TM-T79456

  • GNE-955
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    GNE-955

    CAS:
    GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
    Formula:C22H24N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:416.48

    Ref: TM-T15406

  • PIM1-IN-4
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    PIM1-IN-4

    CAS:
    <p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>
    Formula:C27H25BrCl2CuN6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:663.88

    Ref: TM-T73247

  • Pim-1 kinase inhibitor 5
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    Pim-1 kinase inhibitor 5

    CAS:
    <p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>
    Formula:C22H13Cl2N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:406.26

    Ref: TM-T78980

  • PIM1-IN-1
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    PIM1-IN-1

    CAS:
    PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.
    Formula:C25H30N8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.56

    Ref: TM-T12474

  • PIM-IN-2
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    PIM-IN-2

    CAS:
    PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .
    Formula:C19H22N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.4

    Ref: TM-T81460

  • HS94
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    HS94

    CAS:
    <p>HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.</p>
    Formula:C15H15N5O2S
    Purity:95.04%
    Color and Shape:Solid
    Molecular weight:329.38

    Ref: TM-T77777

  • GDC-0339
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    GDC-0339

    CAS:
    GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.
    Formula:C20H22F3N7OS
    Color and Shape:Solid
    Molecular weight:465.5

    Ref: TM-T15376

  • Pim-1 kinase inhibitor 6
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    Pim-1 kinase inhibitor 6

    CAS:
    Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].
    Formula:C21H10BrCl2N3
    Color and Shape:Solid
    Molecular weight:455.13

    Ref: TM-T87213