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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • Upadacitinib tartrate
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    Upadacitinib tartrate

    CAS:
    <p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>
    Formula:C21H33F3N6O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.521

    Ref: TM-T7503L

  • JAK-IN-17
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    JAK-IN-17

    <p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>
    Formula:C33H38F2N6O8
    Color and Shape:Solid
    Molecular weight:684.69

    Ref: TM-T73250

  • TCS 21311
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    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purity:99.39% - ≥98%
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T17019

  • Lepzacitinib
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    Lepzacitinib

    CAS:
    <p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>
    Formula:C18H21N5O3
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:355.39

    Ref: TM-T78207

  • JAK kinase-IN-1
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    JAK kinase-IN-1

    CAS:
    <p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>
    Formula:C17H19F2N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.44

    Ref: TM-T79807

  • JAK-IN-5
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    JAK-IN-5

    CAS:
    <p>JAK-IN-5 is a JAK inhibitor.</p>
    Formula:C27H31FN6O
    Purity:98.1% - 99.37%
    Color and Shape:Solid
    Molecular weight:474.57

    Ref: TM-T11710

  • JAK-IN-1
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    JAK-IN-1

    CAS:
    <p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>
    Formula:C20H24N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.44

    Ref: TM-T11703

  • Tubulin/JAK2-IN-1
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    Tubulin/JAK2-IN-1

    CAS:
    <p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>
    Formula:C22H20N6O3
    Color and Shape:Solid
    Molecular weight:416.43

    Ref: TM-T80921

  • FM-479
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    FM-479

    CAS:
    <p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>
    Formula:C25H26N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:442.523

    Ref: TM-T22333

  • JAK2-IN-4
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    JAK2-IN-4

    CAS:
    <p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>
    Formula:C23H27N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.56

    Ref: TM-T11708

  • TCJL37
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    TCJL37

    CAS:
    <p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>
    Formula:C17H11ClF2N4O2
    Color and Shape:Solid
    Molecular weight:376.74

    Ref: TM-T4666

  • Brepocitinib
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    Brepocitinib

    CAS:
    <p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>
    Formula:C18H21F2N7O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:389.4

    Ref: TM-TQ0010

  • ABBV-712
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    ABBV-712

    CAS:
    <p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>
    Formula:C24H28N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T83218

  • Tyk2-IN-9
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    Tyk2-IN-9

    CAS:
    <p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>
    Formula:C20H17N9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:383.41

    Ref: TM-T13237

  • JAK-IN-24
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    JAK-IN-24

    CAS:
    <p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>
    Formula:C20H25N5O2
    Color and Shape:Solid
    Molecular weight:367.44

    Ref: TM-T73330

  • JAK-IN-4
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    JAK-IN-4

    CAS:
    <p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>
    Formula:C18H21N4Na2O6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:466.341

    Ref: TM-T11705

  • Itacnosertib (hydrocholide)
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    Itacnosertib (hydrocholide)

    CAS:
    <p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>
    Formula:C26H29ClN8O
    Color and Shape:Solid
    Molecular weight:505.01

    Ref: TM-T84696

  • Ginsenoside Rk1
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    Ginsenoside Rk1

    CAS:
    <p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>
    Formula:C42H70O12
    Purity:98.46% - 99.13%
    Color and Shape:Solid
    Molecular weight:767

    Ref: TM-T4S1499

  • JAK-IN-26
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    JAK-IN-26

    CAS:
    <p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>
    Formula:C22H24N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.46

    Ref: TM-T78189

  • QL-1200186
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    QL-1200186

    CAS:
    <p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>
    Formula:C26H27N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:485.54

    Ref: TM-T81331