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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • BMS-911543
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    BMS-911543

    CAS:
    <p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>
    Formula:C23H28N8O
    Purity:97.69% - 99.98%
    Color and Shape:Solid
    Molecular weight:432.52

    Ref: TM-T6790

  • SAR-20347
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    SAR-20347

    CAS:
    <p>SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).</p>
    Formula:C21H18ClFN4O4
    Purity:98.99% - 99.77%
    Color and Shape:Solid
    Molecular weight:444.84

    Ref: TM-T4210

  • FM-381
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    FM-381

    CAS:
    <p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>
    Formula:C24H24N6O2
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:428.49

    Ref: TM-T5091

  • TG101209
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    TG101209

    CAS:
    <p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>
    Formula:C26H35N7O2S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:509.67

    Ref: TM-T3065

  • Deucravacitinib
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    Deucravacitinib

    CAS:
    <p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C20H19D3N8O3
    Purity:98.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:425.46

    Ref: TM-T14687

  • RO495
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    RO495

    CAS:
    <p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>
    Formula:C17H14Cl2N6O
    Purity:97.94%
    Color and Shape:Solid
    Molecular weight:389.24

    Ref: TM-T22416

  • SC99
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    SC99

    CAS:
    <p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>
    Formula:C15H8Cl2FN3O
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:336.15

    Ref: TM-T8719

  • Brevilin A
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    Brevilin A

    CAS:
    <p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>
    Formula:C20H26O5
    Purity:99.97% - >99.99%
    Color and Shape:Solid
    Molecular weight:346.42

    Ref: TM-T4672

  • Cerdulatinib hydrochloride
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    Cerdulatinib hydrochloride

    CAS:
    <p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 &lt; 200 nM.</p>
    Formula:C20H28ClN7O3S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:482

    Ref: TM-T6104

  • GS-829845
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    GS-829845

    CAS:
    <p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>
    Formula:C17H19N5O2S
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:357.43

    Ref: TM-T67905

  • NVP-BSK805
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    NVP-BSK805

    CAS:
    <p>NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.</p>
    Formula:C27H28F2N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490.55

    Ref: TM-T5049

  • CymitQuimica logo
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    Solrikitug

    CAS:
    <p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>
    Purity:95%
    Color and Shape:Liquid

    Ref: TM-T9901A-527

  • ZM39923
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    ZM39923

    CAS:
    <p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>
    Formula:C23H25NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:331.45

    Ref: TM-T17295

  • (3S,4S)-Tofacitinib
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    (3S,4S)-Tofacitinib

    CAS:
    <p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>
    Formula:C16H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:312.37

    Ref: TM-T13426L

  • SD-1029
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    SD-1029

    CAS:
    <p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>
    Formula:C25H32Br2Cl2N2O3
    Color and Shape:Solid
    Molecular weight:639.25

    Ref: TM-T24774

  • JAK-IN-11
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    JAK-IN-11

    CAS:
    <p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>
    Formula:C23H22FN5O4S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:483.52

    Ref: TM-T12549

  • JAK-IN-20
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    JAK-IN-20

    CAS:
    <p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>
    Formula:C28H30FN7O2
    Color and Shape:Solid
    Molecular weight:515.58

    Ref: TM-T63581

  • JAK-2/3-IN-2
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    JAK-2/3-IN-2

    CAS:
    <p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 &amp; JAK3 inhibitor with IC50s of 23.85 nM (JAK2) &amp; 18.9 nM (JAK3).</p>
    Formula:C19H19ClN2OS
    Color and Shape:Solid
    Molecular weight:358.89

    Ref: TM-T61323

  • Peficitinib hydrochloride
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    Peficitinib hydrochloride

    CAS:
    <p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>
    Formula:C18H23ClN4O2
    Color and Shape:Solid
    Molecular weight:362.86

    Ref: TM-T61365

  • TK4b
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    TK4b

    CAS:
    <p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) &amp; 19.40 nM (JAK2).</p>
    Formula:C21H22N2O2
    Color and Shape:Solid
    Molecular weight:334.41

    Ref: TM-T61020