Protosappanin A
CAS: 102036-28-2
Ref. TM-TJS1779
1mg | 143.00 € | ||
5mg | 423.00 € | ||
10mg | 624.00 € | ||
25mg | 984.00 € | ||
50mg | 1,327.00 € | ||
100mg | 1,782.00 € | ||
1ml*10 (DMSO) | 366.00 € |
Product Information
- PTA
- 3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one
- 3,10,11-trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one
- 6H-Dibenz(b,d)oxocin-7(8H)-one, 3,10,11-trihydroxy-
- Sappanol B
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
Chemical properties
Technical inquiry about: TM-TJS1779 Protosappanin A
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