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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • OICR-0547
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    OICR-0547

    CAS:
    <p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>
    Formula:C28H29F3N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:542.55

    Ref: TM-T12290

  • INCB16562
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    INCB16562

    CAS:
    <p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>
    Formula:C19H11Cl2N5
    Color and Shape:Solid
    Molecular weight:380.23

    Ref: TM-T68306

  • JAK3-IN-9
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    JAK3-IN-9

    CAS:
    <p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>
    Formula:C17H23N5O4S
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T61814

  • TUL01101
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    TUL01101

    CAS:
    <p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>
    Formula:C22H25F2N5O2
    Color and Shape:Solid
    Molecular weight:429.46

    Ref: TM-T73392

  • CP-690550A
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    CP-690550A

    CAS:
    <p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>
    Formula:C15H21N5O2
    Color and Shape:Solid
    Molecular weight:303.36

    Ref: TM-T31074

  • GDC-4379
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    GDC-4379

    CAS:
    <p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>
    Formula:C21H18ClF2N7O3
    Color and Shape:Solid
    Molecular weight:489.86

    Ref: TM-T63280

  • Peficitinib hydrobromide
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    Peficitinib hydrobromide

    CAS:
    <p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>
    Formula:C18H23BrN4O2
    Color and Shape:Solid
    Molecular weight:407.312

    Ref: TM-T33905

  • Povorcitinib
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    Povorcitinib

    CAS:
    <p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>
    Formula:C23H22F5N7O
    Color and Shape:Solid
    Molecular weight:507.469

    Ref: TM-T39113

  • (2R,5S)-Ritlecitinib
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    (2R,5S)-Ritlecitinib

    CAS:
    <p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>
    Formula:C15H19N5O
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T60565

  • TYK2-IN-11
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    TYK2-IN-11

    CAS:
    <p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>
    Formula:C18H17N5O3S
    Color and Shape:Solid
    Molecular weight:383.42

    Ref: TM-T61658

  • Thi-DPPY
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    Thi-DPPY

    CAS:
    <p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>
    Formula:C28H28ClN5O4S
    Color and Shape:Solid
    Molecular weight:566.07

    Ref: TM-T64008

  • PF-00956980
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    PF-00956980

    CAS:
    <p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>
    Formula:C18H26N6O
    Color and Shape:Solid
    Molecular weight:342.44

    Ref: TM-T71089

  • SYK/JAK-IN-1
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    SYK/JAK-IN-1

    CAS:
    <p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>
    Formula:C24H26N8O3
    Color and Shape:Solid
    Molecular weight:474.52

    Ref: TM-T63086

  • JAK3-IN-1
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    JAK3-IN-1

    CAS:
    <p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>
    Formula:C26H30ClN7O2
    Color and Shape:Solid
    Molecular weight:508.02

    Ref: TM-T15607

  • JAK-IN-10
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    JAK-IN-10

    CAS:
    <p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>
    Formula:C20H18FN5O3S
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:427.45

    Ref: TM-T13571

  • JAK-IN-28
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    JAK-IN-28

    CAS:
    <p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>
    Formula:C20H18ClN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.86

    Ref: TM-T79116

  • JAK-IN-30
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    JAK-IN-30

    CAS:
    <p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>
    Formula:C19H26N8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:398.53

    Ref: TM-T79235

  • JAK1-IN-4
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    JAK1-IN-4

    CAS:
    <p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>
    Formula:C26H32FN9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:521.59

    Ref: TM-T15606

  • JAK3/BTK-IN-2
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    JAK3/BTK-IN-2

    CAS:
    <p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>
    Formula:C25H32N8O2
    Purity:99.64% - 99.87%
    Color and Shape:Solid
    Molecular weight:476.57

    Ref: TM-T9813

  • Lorpucitinib
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    Lorpucitinib

    CAS:
    <p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>
    Formula:C22H28N6O2
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:408.5

    Ref: TM-T62053

  • JAK3i
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    JAK3i

    CAS:
    <p>JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.</p>
    Formula:C18H15FN4O3
    Purity:98.61% - 99.81%
    Color and Shape:Solid
    Molecular weight:354.34

    Ref: TM-T27650

  • Jaspamycin
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    Jaspamycin

    CAS:
    <p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>
    Formula:C12H12N4O5
    Color and Shape:Solid
    Molecular weight:292.25

    Ref: TM-T11711

  • JAK3/BTK-IN-1
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    JAK3/BTK-IN-1

    CAS:
    <p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>
    Formula:C25H28N8O
    Purity:97.89%
    Color and Shape:Solid
    Molecular weight:456.54

    Ref: TM-T9814

  • Izencitinib
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    Izencitinib

    CAS:
    <p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>
    Formula:C22H26N8
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:402.50

    Ref: TM-T35898

  • STS-E412
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    STS-E412

    CAS:
    <p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>
    Formula:C15H15ClN4O2
    Purity:99.01%
    Color and Shape:Solid
    Molecular weight:318.76

    Ref: TM-T24840

  • JAK1-IN-8
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    JAK1-IN-8

    CAS:
    <p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50&lt;500 nM).</p>
    Formula:C22H23FN4O3S
    Purity:98.4%
    Color and Shape:Solid
    Molecular weight:442.51

    Ref: TM-T35899

  • JAK-STAT-IN-1
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    JAK-STAT-IN-1

    CAS:
    <p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>
    Formula:C21H21N5O2
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T78607

  • Butyzamide
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    Butyzamide

    CAS:
    <p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>
    Formula:C29H32Cl2N2O5S
    Purity:99.51% - 99.83%
    Color and Shape:Soild
    Molecular weight:591.55

    Ref: TM-T67894

  • JAK-IN-25
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    JAK-IN-25

    CAS:
    <p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>
    Formula:C19H17N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:379.37

    Ref: TM-T78175

  • Nezulcitinib
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    Nezulcitinib

    CAS:
    <p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>
    Formula:C30H37N7O2
    Color and Shape:Solid
    Molecular weight:527.66

    Ref: TM-T63709

  • Upadacitinib tartrate
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    Upadacitinib tartrate

    CAS:
    <p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>
    Formula:C21H33F3N6O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.521

    Ref: TM-T7503L

  • JAK-IN-17
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    JAK-IN-17

    <p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>
    Formula:C33H38F2N6O8
    Color and Shape:Solid
    Molecular weight:684.69

    Ref: TM-T73250

  • TCS 21311
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    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purity:99.39% - ≥98%
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T17019

  • Lepzacitinib
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    Lepzacitinib

    CAS:
    <p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>
    Formula:C18H21N5O3
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:355.39

    Ref: TM-T78207

  • JAK kinase-IN-1
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    JAK kinase-IN-1

    CAS:
    <p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>
    Formula:C17H19F2N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.44

    Ref: TM-T79807

  • JAK-IN-5
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    JAK-IN-5

    CAS:
    <p>JAK-IN-5 is a JAK inhibitor.</p>
    Formula:C27H31FN6O
    Purity:98.1% - 99.37%
    Color and Shape:Solid
    Molecular weight:474.57

    Ref: TM-T11710

  • JAK-IN-1
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    JAK-IN-1

    CAS:
    <p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>
    Formula:C20H24N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.44

    Ref: TM-T11703

  • Tubulin/JAK2-IN-1
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    Tubulin/JAK2-IN-1

    CAS:
    <p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>
    Formula:C22H20N6O3
    Color and Shape:Solid
    Molecular weight:416.43

    Ref: TM-T80921

  • FM-479
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    FM-479

    CAS:
    <p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>
    Formula:C25H26N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:442.523

    Ref: TM-T22333

  • JAK2-IN-4
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    JAK2-IN-4

    CAS:
    <p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>
    Formula:C23H27N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.56

    Ref: TM-T11708

  • TCJL37
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    TCJL37

    CAS:
    <p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>
    Formula:C17H11ClF2N4O2
    Color and Shape:Solid
    Molecular weight:376.74

    Ref: TM-T4666

  • Brepocitinib
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    Brepocitinib

    CAS:
    <p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>
    Formula:C18H21F2N7O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:389.4

    Ref: TM-TQ0010

  • ABBV-712
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    ABBV-712

    CAS:
    <p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>
    Formula:C24H28N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T83218

  • Tyk2-IN-9
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    Tyk2-IN-9

    CAS:
    <p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>
    Formula:C20H17N9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:383.41

    Ref: TM-T13237

  • JAK-IN-24
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    JAK-IN-24

    CAS:
    <p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>
    Formula:C20H25N5O2
    Color and Shape:Solid
    Molecular weight:367.44

    Ref: TM-T73330

  • JAK-IN-4
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    JAK-IN-4

    CAS:
    <p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>
    Formula:C18H21N4Na2O6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:466.341

    Ref: TM-T11705

  • Itacnosertib (hydrocholide)
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    Itacnosertib (hydrocholide)

    CAS:
    <p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>
    Formula:C26H29ClN8O
    Color and Shape:Solid
    Molecular weight:505.01

    Ref: TM-T84696

  • Ginsenoside Rk1
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    Ginsenoside Rk1

    CAS:
    <p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>
    Formula:C42H70O12
    Purity:98.46% - 99.13%
    Color and Shape:Solid
    Molecular weight:767

    Ref: TM-T4S1499

  • JAK-IN-26
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    JAK-IN-26

    CAS:
    <p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>
    Formula:C22H24N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.46

    Ref: TM-T78189

  • QL-1200186
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    QL-1200186

    CAS:
    <p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>
    Formula:C26H27N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:485.54

    Ref: TM-T81331