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JNK

JNK

JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.

Found 103 products of "JNK"

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  • JNK-IN-21
    Targetmol
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    JNK-IN-21

    CAS:
    <p>JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.</p>
    Formula:C19H16N2O2S
    Color and Shape:Solid
    Molecular weight:336.408

    Ref: TM-T204504

  • CymitQuimica logo
    Targetmol
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    JAK3-IN-13

    JAK3-IN-13: Oral JAK3 inhibitor, selective & potent. Acts on NK1, JNK2, JNK3, Tyk2. Anti-tumor. IC50: JNK3, 8 nM; Tyk2, 365 nM; JNK2, 2039 nM; NK1, 4728 nM.
    Formula:C25H33ClN6O5
    Color and Shape:Solid
    Molecular weight:533.02

    Ref: TM-T63749

  • JNK-1-IN-4
    Targetmol
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    JNK-1-IN-4

    CAS:
    <p>JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.</p>
    Formula:C22H25BrN6O3
    Color and Shape:Solid
    Molecular weight:501.38

    Ref: TM-T200667