JNK
JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.
Found 104 products for "JNK".
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JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formula:C29H29N7O2Purity:99.24% - >99.99%Color and Shape:White SolidMolecular weight:507.59Ref: TM-T2668
2mg44.00€5mg73.00€1mL*10mM (DMSO)82.00€10mg113.00€25mg197.00€50mg326.00€100mg482.00€200mg685.00€Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formula:C20H24O5Purity:97.00%Color and Shape:SolidMolecular weight:344.4TRi-1
CAS:TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.Formula:C12H9ClN2O5SPurity:97.14%Color and Shape:SolidMolecular weight:328.73Ref: TM-T5481
1mg70.00€2mg89.00€5mg137.00€1mL*10mM (DMSO)150.00€10mg205.00€25mg340.00€50mg485.00€100mg700.00€Ref: TM-T6S1371
1mg49.00€5mg92.00€1mL*10mM (DMSO)100.00€10mg133.00€25mg259.00€50mg358.00€100mg530.00€200mg755.00€IQ-3
CAS:IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.Formula:C20H11N3O3Purity:≥98%Color and Shape:White SolidMolecular weight:341.32Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Formula:C16H11N3O2Purity:98.34%Color and Shape:SolidMolecular weight:277.28Ref: TM-T9138
1mg44.00€1mL*10mM (DMSO)92.00€5mg93.00€10mg120.00€25mg236.00€50mg356.00€100mg532.00€200mg772.00€IQ-1S free acid
CAS:IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formula:C15H9N3OPurity:97.92% - 99.05%Color and Shape:SolidMolecular weight:247.25Ref: TM-T3627
5mg44.00€1mL*10mM (DMSO)48.00€10mg50.00€25mg90.00€50mg160.00€100mg289.00€200mg430.00€500mg695.00€Taurochenodeoxycholic acid sodium
CAS:Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Formula:C26H44NNaO6SPurity:98.23% - 99.56%Color and Shape:White SolidMolecular weight:521.68Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:99.54% - ≥95%Color and Shape:White SolidMolecular weight:327.83CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formula:C16H27N5O2Purity:99.96%Color and Shape:White SolidMolecular weight:321.42Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formula:C48H76O21Purity:98.9% - 99.3%Color and Shape:White SolidMolecular weight:989.1TCS JNK 5a
CAS:TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).Formula:C20H16N2OSPurity:99.22% - 99.51%Color and Shape:SolidMolecular weight:332.42Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purity:99.12% - >99.99%Color and Shape:SolidMolecular weight:947.15Ref: TM-T2872
2mg34.00€5mg48.00€10mg63.00€1mL*10mM (DMSO)65.00€25mg92.00€50mg138.00€100mg197.00€200mg290.00€WHI-P258
CAS:WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formula:C16H15N3O2Purity:99.66% - 99.92%Color and Shape:SolidMolecular weight:281.31Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Formula:C27H45NO2Purity:99.94% - 99.98%Color and Shape:White SolidMolecular weight:415.65Sesamolin
CAS:Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Formula:C20H18O7Purity:98.77% - 99.04%Color and Shape:White SolidMolecular weight:370.35Ref: TM-T5S2283
1mg35.00€2mg50.00€5mg75.00€1mL*10mM (DMSO)84.00€10mg120.00€25mg197.00€50mg294.00€100mg437.00€200mg622.00€Pamapimod
CAS:Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Formula:C19H20F2N4O4Purity:99.52% - 99.99%Color and Shape:SolidMolecular weight:406.38TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormula:C17H15F3N2O4Color and Shape:SolidMolecular weight:368.31SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurity:99.38% - 99.71%Color and Shape:SolidMolecular weight:490.56Ref: TM-T16927
1mg49.00€5mg98.00€1mL*10mM (DMSO)108.00€10mg152.00€25mg288.00€50mg520.00€100mg835.00€500mg1,674.00€SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Formula:C29H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:512.53
