MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
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K-Ras G12C-IN-4
CAS:<p>K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。</p>Formula:C31H33ClN4O4Purity:99.00%Color and Shape:SolidMolecular weight:561.07Tanzisertib
CAS:<p>Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.</p>Formula:C21H23F3N6O2Purity:98.66% - 99.28%Color and Shape:SolidMolecular weight:448.44MRTX-1257
CAS:<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Formula:C33H39N7O2Purity:97.3% - 99.07%Color and Shape:SolidMolecular weight:565.71GW806742X
CAS:<p>GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.</p>Formula:C25H22F3N7O4SPurity:98.3%Color and Shape:SolidMolecular weight:573.55Methylthiouracil
CAS:<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formula:C5H6N2OSPurity:99.89% - >99.99%Color and Shape:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Molecular weight:142.18RMC-6236
CAS:<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Formula:C44H58N8O5SPurity:98.24% - 99.92%Color and Shape:SolidMolecular weight:811.05ARS-1630
CAS:<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Formula:C21H17ClF2N4O2Purity:97.78%Color and Shape:SolidMolecular weight:430.84KRAS G12C inhibitor 19
CAS:<p>KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.</p>Formula:C25H19ClF2N4O3SPurity:97.46%Color and Shape:SolidMolecular weight:528.96SU3327
CAS:<p>SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).</p>Formula:C5H3N5O2S3Purity:98.39%Color and Shape:SolidMolecular weight:261.3LUT014
CAS:<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formula:C27H19F3N8OPurity:99.03%Color and Shape:SolidMolecular weight:528.49BI-3406
CAS:<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Formula:C23H25F3N4O3Purity:99.2% - 99.66%Color and Shape:SolidMolecular weight:462.46INH154
CAS:<p>INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.</p>Formula:C22H24N4OSPurity:99.95%Color and Shape:SolidMolecular weight:392.52MAP4K4-IN-3
CAS:<p>MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.</p>Formula:C15H12ClN5Purity:98.07%Color and Shape:SolidMolecular weight:297.74PF-3644022
CAS:<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Formula:C21H18N4OSPurity:98.13%Color and Shape:SolidMolecular weight:374.46MRTX0902
CAS:<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Formula:C22H24N6OPurity:99.69%Color and Shape:SolidMolecular weight:388.47Divarasib
CAS:<p>Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.</p>Formula:C29H32ClF4N7O2Purity:99.237% - 99.83%Color and Shape:SolidMolecular weight:622.06MK2-IN-3 hydrate
CAS:<p>MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)</p>Formula:C21H18N4O2Purity:99.58%Color and Shape:SolidMolecular weight:358.39CC-90003
CAS:<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Formula:C22H21F3N6O2Purity:99.42%Color and Shape:SolidMolecular weight:458.44ETC-206
CAS:<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Formula:C25H20N4O2Purity:99.72% - 99.79%Color and Shape:SolidMolecular weight:408.45Regorafénib N-oxyde (M2)
CAS:<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Formula:C21H15ClF4N4O4Purity:98.03% - 98.26%Color and Shape:SolidMolecular weight:498.81
