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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • KRAS G12C inhibitor 15
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    KRAS G12C inhibitor 15

    CAS:
    <p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>
    Formula:C25H21ClF2N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.91

    Ref: TM-T11769

  • CK1δ-IN-9
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    CK1δ-IN-9

    CAS:
    <p>CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.</p>
    Formula:C16H12FN5
    Color and Shape:Solid
    Molecular weight:293.298

    Ref: TM-T205445

  • p38-α MAPK-IN-10
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    p38-α MAPK-IN-10

    CAS:
    <p>p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.</p>
    Formula:C27H34Cl2N6
    Color and Shape:Solid
    Molecular weight:513.505

    Ref: TM-T205642

  • p38-α MAPK-IN-9
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    p38-α MAPK-IN-9

    CAS:
    <p>p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.</p>
    Formula:C19H20N8O2
    Color and Shape:Solid
    Molecular weight:392.414

    Ref: TM-T205389

  • Casein kinase 1δ-IN-31
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    Casein kinase 1δ-IN-31

    CAS:
    <p>Casein kinase1δ-IN-31 (Compound 16) is an inhibitor of casein kinase (CK), specifically targeting CK1α, CK1δ, and p38α, with IC50 values of 196 nM, 17 nM, and 18 nM, respectively. Additionally, Casein kinase1δ-IN-31 inhibits Double Homeobox 4 (DUX4) with an IC50 of 1200 nM.</p>
    Formula:C17H13FN4
    Color and Shape:Solid
    Molecular weight:292.31

    Ref: TM-T205233

  • pan-KRAS-IN-17
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    pan-KRAS-IN-17

    CAS:
    <p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>
    Formula:C34H33F3N5O8P
    Color and Shape:Solid
    Molecular weight:727.623

    Ref: TM-T205570

  • AM-001
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    AM-001

    CAS:
    <p>AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.</p>
    Formula:C24H16FN3OS2
    Color and Shape:Solid
    Molecular weight:445.53

    Ref: TM-T201281

  • J-104871
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    J-104871

    CAS:
    <p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>
    Formula:C38H32N2O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:708.67

    Ref: TM-T24188

  • KRAS inhibitor-37
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    KRAS inhibitor-37

    CAS:
    <p>KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from &lt;2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.</p>
    Formula:C32H33ClFN7O3
    Color and Shape:Solid
    Molecular weight:618.10

    Ref: TM-T201259

  • KRAS G12C inhibitor 20
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    KRAS G12C inhibitor 20

    CAS:
    <p>KRAS G12C inhibitor 20 is a KRAS G12C inhibitor.</p>
    Formula:C33H37ClFN7O3
    Color and Shape:Solid
    Molecular weight:634.14

    Ref: TM-T72346

  • KRAS G12C inhibitor 56
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    KRAS G12C inhibitor 56

    CAS:
    <p>KRAS G12C inhibitor 56, a powerful inhibitor of SOS1 with an inhibitory concentration (IC50) of 1.6 nM, holds promise for use in cancer research.</p>
    Formula:C32H39N7O4S
    Color and Shape:Solid
    Molecular weight:617.76

    Ref: TM-T72356

  • p38α MAPK/CK1δ inhibitor-1
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    p38α MAPK/CK1δ inhibitor-1

    CAS:
    <p>p38αMAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.185 µM and 0.089 µM, respectively.</p>
    Formula:C24H17FN6O2
    Color and Shape:Solid
    Molecular weight:440.429

    Ref: TM-T205722

  • EBI-1051
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    EBI-1051

    CAS:
    <p>EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).</p>
    Formula:C18H15F2IN2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:504.22

    Ref: TM-T15193

  • G-479
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    G-479

    CAS:
    <p>G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.</p>
    Formula:C16H15FIN5O4
    Color and Shape:Solid
    Molecular weight:487.22

    Ref: TM-T71344

  • NHTD
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    NHTD

    CAS:
    <p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>
    Formula:C24H26N2O5
    Color and Shape:Solid
    Molecular weight:422.47

    Ref: TM-T200095

  • SOS2 ligand 1
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    SOS2 ligand 1

    CAS:
    <p>SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.</p>
    Formula:C19H21N5O
    Color and Shape:Solid
    Molecular weight:335.403

    Ref: TM-T204872

  • Brimarafenib
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    Brimarafenib

    CAS:
    <p>Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.</p>
    Formula:C24H17F3N4O4
    Purity:98.32%
    Color and Shape:Solid
    Molecular weight:482.41

    Ref: TM-T89116

  • KRAS G12D inhibitor 16
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    KRAS G12D inhibitor 16

    CAS:
    <p>KRAS G12D inhibitor 16 targets KRAS G12D with IC50 of 0.7 nM and mutant form at 0.35 μM, useful in various cancer studies.</p>
    Formula:C32H39IN6O3
    Color and Shape:Solid
    Molecular weight:682.59

    Ref: TM-T72355

  • pan-KRAS degrader 1
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    pan-KRAS degrader 1

    CAS:
    <p>Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.</p>
    Formula:C22H26N8OS
    Color and Shape:Solid
    Molecular weight:450.56

    Ref: TM-T200566

  • MRTX849 acid
    Targetmol
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    MRTX849 acid

    CAS:
    <p>MRTX849 acid, used to make PROTAC LC-2, effectively degrades KRAS G12C at 0.25-0.76 μM DC50.</p>
    Formula:C34H37ClFN7O4
    Color and Shape:Solid
    Molecular weight:662.16

    Ref: TM-T40189