MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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ML-191
CAS:931695-79-3
ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.
Formula:
C24H25N3O3
Purity:
99.58%
Color and Shape:
Solid
Molecular weight:
403.47
Ref: TM-T22996
| 1mg | 36.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 214.00 € | ||
| 50mg | 349.00 € | ||
| 100mg | 515.00 € | ||
| 500mg | 1,091.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BIX02189
CAS:1094614-85-3
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
Formula:
C27H28N4O2
Purity:
98% - 99.86%
Color and Shape:
Solid
Molecular weight:
440.54
Ref: TM-T2416
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 121.00 € | ||
| 25mg | 217.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 634.00 € | ||
| 200mg | 885.00 € | ||
| 500mg | 1,291.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
TAK-715
CAS:303162-79-0
TAK-715 is a p38 MAPK inhibitor for p38α.
Formula:
C24H21N3OS
Purity:
99.69%
Color and Shape:
Solid
Molecular weight:
399.51
Ref: TM-T6150
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 172.00 € | ||
| 50mg | 317.00 € | ||
| 100mg | 497.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CMPD1
CAS:41179-33-3
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
Formula:
C22H20FNO2
Purity:
99.67%
Color and Shape:
Solid
Molecular weight:
349.4
Ref: TM-T14988
| 1mg | 37.00 € | ||
| 5mg | 103.00 € | ||
| 10mg | 158.00 € | ||
| 25mg | 278.00 € | ||
| 50mg | 437.00 € | ||
| 100mg | 677.00 € | ||
| 500mg | 1,576.00 € | ||
| 1mL*10mM (DMSO) | 113.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
K-Ras(G12C) Inhibitor 6
CAS:2060530-16-5
Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Formula:
C17H22Cl2N2O3S
Purity:
100% - 97.01%
Color and Shape:
Solid
Molecular weight:
405.33
Ref: TM-T3725
| 1mg | 62.00 € | ||
| 2mg | 88.00 € | ||
| 5mg | 131.00 € | ||
| 10mg | 228.00 € | ||
| 25mg | 472.00 € | ||
| 50mg | 659.00 € | ||
| 100mg | 920.00 € | ||
| 1mL*10mM (DMSO) | 131.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SB 239063
CAS:193551-21-2
SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 …
Formula:
C20H21FN4O2
Purity:
99.42% - 99.81%
Color and Shape:
Solid
Molecular weight:
368.4
Ref: TM-T6976
| 1mg | 50.00 € | ||
| 2mg | 63.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 156.00 € | ||
| 25mg | 330.00 € | ||
| 50mg | 495.00 € | ||
| 100mg | 712.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
XMD17-109
CAS:1435488-37-1
XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).
Formula:
C36H46N8O3
Purity:
98.86% - 99.75%
Color and Shape:
Solid
Molecular weight:
638.8
Ref: TM-T1842
| 1mg | 41.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 217.00 € | ||
| 50mg | 350.00 € | ||
| 100mg | 527.00 € | ||
| 1mL*10mM (DMSO) | 110.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Corynoxeine
CAS:630-94-4
Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and …
Formula:
C22H26N2O4
Purity:
98.61% - 99.73%
Color and Shape:
Solid
Molecular weight:
382.45
Ref: TM-T6S0655
| 1mg | 47.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 172.00 € | ||
| 25mg | 276.00 € | ||
| 50mg | 420.00 € | ||
| 100mg | 606.00 € | ||
| 500mg | 1,252.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NVP-BHG712
CAS:940310-85-0
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR …
Formula:
C26H20F3N7O
Purity:
97.96%
Color and Shape:
Solid
Molecular weight:
503.48
Ref: TM-T6348
| 1mg | 36.00 € | ||
| 2mg | 57.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 212.00 € | ||
| 50mg | 389.00 € | ||
| 100mg | 582.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Belvarafenib
CAS:1446113-23-0
Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and …
Formula:
C23H16ClFN6OS
Purity:
99.44% - ≥98%
Color and Shape:
Solid
Molecular weight:
478.93
Ref: TM-T5634
| 2mg | 40.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 99.00 € | ||
| 25mg | 165.00 € | ||
| 50mg | 237.00 € | ||
| 100mg | 353.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
A-674563 2HCl(552325-73-2(fb-2hcl))
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA …
Formula:
C22H24Cl2N4O
Purity:
94.66%
Color and Shape:
Solid
Molecular weight:
431.36
Ref: TM-T6139L
| 1mg | 85.00 € | ||
| 5mg | 137.00 € | ||
| 10mg | 186.00 € | ||
| 25mg | 332.00 € | ||
| 50mg | 499.00 € | ||
| 100mg | 722.00 € | ||
| 1mL*10mM (DMSO) | 168.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Cornuside
CAS:131189-57-6
Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by …
Formula:
C24H30O14
Purity:
100% - 99.57%
Color and Shape:
Solid
Molecular weight:
542.49
Ref: TM-T4S2326
| 1mg | 94.00 € | ||
| 5mg | 259.00 € | ||
| 10mg | 409.00 € | ||
| 25mg | 662.00 € | ||
| 50mg | 915.00 € | ||
| 100mg | 1,230.00 € | ||
| 500mg | 2,471.00 € | ||
| 1mL*10mM (DMSO) | 334.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AZD8330
CAS:869357-68-6
AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 …
Formula:
C16H17FIN3O4
Purity:
98.72%
Color and Shape:
Solid
Molecular weight:
461.23
Ref: TM-T6083
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 198.00 € | ||
| 50mg | 299.00 € | ||
| 1mL*10mM (DMSO) | 80.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Bentamapimod
CAS:848344-36-5
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.
Formula:
C25H23N5O2S
Purity:
95.21% - 99.92%
Color and Shape:
Solid
Molecular weight:
457.55
Ref: TM-T2675
| 1g | 2,033.00 € | ||
| 2g | 2,739.00 € | ||
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 159.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 344.00 € | ||
| 500mg | 1,131.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AG126
CAS:118409-62-4
AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly …
Formula:
C10H5N3O3
Purity:
98.72%
Color and Shape:
Solid
Molecular weight:
215.16
Ref: TM-T4092
| 1mg | 35.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 219.00 € | ||
| 50mg | 325.00 € | ||
| 100mg | 482.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
ERK1/2 inhibitor 2
CAS:2095719-92-7
ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential …
Formula:
C29H31ClFN5O5
Purity:
98.99%
Color and Shape:
Solid
Molecular weight:
584.04
Ref: TM-T8472
| 1mg | 48.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 150.00 € | ||
| 25mg | 231.00 € | ||
| 50mg | 418.00 € | ||
| 100mg | 612.00 € | ||
| 1mL*10mM (DMSO) | 122.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BAY-293
CAS:2244904-70-7
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
Formula:
C25H28N4O2S
Purity:
96.8%
Color and Shape:
Solid
Molecular weight:
448.58
Ref: TM-T5418
| 1mg | 52.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 368.00 € | ||
| 50mg | 547.00 € | ||
| 100mg | 786.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SD 0006
CAS:271576-80-8
SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the …
Formula:
C20H20ClN5O2
Purity:
98.32%
Color and Shape:
Solid
Molecular weight:
397.86
Ref: TM-T7276
| 2mg | 37.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 89.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 220.00 € | ||
| 100mg | 328.00 € | ||
| 200mg | 459.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AZ7550
CAS:1421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Formula:
C27H31N7O2
Purity:
97.07%
Color and Shape:
Solid
Molecular weight:
485.58
Ref: TM-T13564
| 1mg | 129.00 € | ||
| 5mg | 282.00 € | ||
| 10mg | 417.00 € | ||
| 25mg | 689.00 € | ||
| 50mg | 920.00 € | ||
| 100mg | 1,287.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Encorafenib
CAS:1269440-17-6
Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
Formula:
C22H27ClFN7O4S
Purity:
98.64% - 99.74%
Color and Shape:
Solid
Molecular weight:
540.01
Ref: TM-T6487
| 1mg | 51.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 120.00 € | ||
| 25mg | 184.00 € | ||
| 50mg | 350.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
