MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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K-Ras(G12C) inhibitor 9
CAS:1469337-91-4
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
Formula:
C16H21ClIN3O4S
Purity:
97.33% - 97.45%
Color and Shape:
Solid
Molecular weight:
513.78
Ref: TM-T6556
| 1mg | 52.00 € | ||
| 2mg | 73.00 € | ||
| 5mg | 122.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 373.00 € | ||
| 50mg | 541.00 € | ||
| 100mg | 740.00 € | ||
| 1mL*10mM (DMSO) | 181.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
PF-06260933
CAS:1811510-56-1
PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM …
Formula:
C16H13ClN4
Purity:
99.63% - 99.97%
Color and Shape:
Solid
Molecular weight:
296.75
Ref: TM-T4221
| 1mg | 49.00 € | ||
| 2mg | 63.00 € | ||
| 5mg | 101.00 € | ||
| 10mg | 161.00 € | ||
| 25mg | 319.00 € | ||
| 50mg | 511.00 € | ||
| 100mg | 735.00 € | ||
| 1mL*10mM (DMSO) | 103.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
D-JNKI-1 acetate
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.
Formula:
C166H290N66O42
Purity:
99.48%
Color and Shape:
Solid
Molecular weight:
3882.5
Ref: TM-T10937L
| 1mg | 161.00 € | ||
| 5mg | 306.00 € | ||
| 10mg | 456.00 € | ||
| 25mg | 730.00 € | ||
| 50mg | 1,041.00 € | ||
| 100mg | 1,374.00 € | ||
| 1mL*10mM (DMSO) | 1,142.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SGX-523
CAS:1022150-57-7
SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, …
Formula:
C18H13N7S
Purity:
100% - 99.6%
Color and Shape:
Solid
Molecular weight:
359.41
Ref: TM-T2293
| 1mg | 52.00 € | ||
| 2mg | 66.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 272.00 € | ||
| 50mg | 439.00 € | ||
| 100mg | 648.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Longdaysin
CAS:1353867-91-0
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit …
Formula:
C16H16F3N5
Purity:
99.97%
Color and Shape:
Solid
Molecular weight:
335.33
Ref: TM-T5358
| 5mg | 50.00 € | ||
| 10mg | 74.00 € | ||
| 25mg | 135.00 € | ||
| 50mg | 208.00 € | ||
| 100mg | 315.00 € | ||
| 200mg | 451.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Temuterkib
CAS:1951483-29-6
LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.
Formula:
C22H27N7O2S
Purity:
100% - 99.76%
Color and Shape:
Solid
Molecular weight:
453.56
Ref: TM-T4091
| 1mg | 69.00 € | ||
| 2mg | 90.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 185.00 € | ||
| 25mg | 399.00 € | ||
| 50mg | 603.00 € | ||
| 100mg | 854.00 € | ||
| 500mg | 1,734.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
TBAP-001
CAS:1777832-90-2
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E …
Formula:
C27H23F2N7O3
Purity:
99.3%
Color and Shape:
Solid
Molecular weight:
531.51
Ref: TM-T9693
| 1mg | 74.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 247.00 € | ||
| 25mg | 447.00 € | ||
| 50mg | 671.00 € | ||
| 100mg | 932.00 € | ||
| 1mL*10mM (DMSO) | 181.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.
Formula:
C110H186N44O27S2
Purity:
98.94%
Color and Shape:
Solid
Molecular weight:
2621.06
Ref: TM-TP2358
| 1mg | 49.00 € | ||
| 5mg | 115.00 € | ||
| 10mg | 172.00 € | ||
| 25mg | 273.00 € | ||
| 50mg | 405.00 € | ||
| 100mg | 542.00 € | ||
| 200mg | 717.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Plx-4032
CAS:1029872-54-5
Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
Formula:
C23H18ClF2N3O3S
Purity:
99.36% - 99.94%
Color and Shape:
Solid
Molecular weight:
489.92
Ref: TM-T8654
| 10mg | 54.00 € | ||
| 50mg | 78.00 € | ||
| 100mg | 97.00 € | ||
| 200mg | 167.00 € | ||
| 500mg | 286.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Maohuoside A
CAS:128988-55-6
Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
Formula:
C27H32O12
Purity:
98.91% - 98.95%
Color and Shape:
Solid
Molecular weight:
548.54
Ref: TM-TN2081
| 1mg | 135.00 € | ||
| 5mg | 326.00 € | ||
| 10mg | 483.00 € | ||
| 25mg | 772.00 € | ||
| 50mg | 1,023.00 € | ||
| 100mg | 1,398.00 € | ||
| 1mL*10mM (DMSO) | 403.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Vemurafenib
CAS:918504-65-1
Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and …
Formula:
C23H18ClF2N3O3S
Purity:
98% - 99.65%
Color and Shape:
Solid
Molecular weight:
489.92
Ref: TM-T2382
| 10mg | 54.00 € | ||
| 50mg | 78.00 € | ||
| 100mg | 97.00 € | ||
| 200mg | 168.00 € | ||
| 500mg | 284.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
5,6,7-TRIMETHOXYFLAVONE
CAS:973-67-1
5,6,7-Trimethoxyflavone, a natural product extracted from Japanese Callicarpa, acts as a p38-α MAPK inhibitor and …
Formula:
C18H16O5
Purity:
99.05% - 99.11%
Color and Shape:
Solid
Molecular weight:
312.32
Ref: TM-T7051
| 1mg | 35.00 € | ||
| 5mg | 68.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 272.00 € | ||
| 100mg | 392.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
IQ-3
CAS:312538-03-7
IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and …
Formula:
C20H11N3O3
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
341.32
Ref: TM-T8477
| 1mg | 40.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 113.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 345.00 € | ||
| 100mg | 512.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
B-Raf IN 11
CAS:918504-27-5
B-Raf IN 11 is a novel selective inhibitor.
Formula:
C17H14BrF2N3O3S
Purity:
99.46%
Color and Shape:
Solid
Molecular weight:
458.28
Ref: TM-T19802
| 50mg | 36.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Butein
CAS:487-52-5
Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.
Formula:
C15H12O5
Purity:
100% - 99.85%
Color and Shape:
Solid
Molecular weight:
272.25
Ref: TM-T6427
| 1mg | 42.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 210.00 € | ||
| 50mg | 337.00 € | ||
| 100mg | 540.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
PROTAC BRAF-V600E degrader-1
CAS:2417296-84-3
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
Formula:
C48H54F2N10O10S
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
1001.07
Ref: TM-T8745
| 1mg | 109.00 € | ||
| 5mg | 292.00 € | ||
| 10mg | 383.00 € | ||
| 25mg | 625.00 € | ||
| 50mg | 844.00 € | ||
| 100mg | 1,126.00 € | ||
| 200mg | 1,528.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Adagrasib
CAS:2326521-71-3
View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor …
Formula:
C32H35ClFN7O2
Purity:
99.10% - 99.9%
Color and Shape:
Solid
Molecular weight:
604.12
Ref: TM-T8369
| 5mg | 65.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 188.00 € | ||
| 50mg | 346.00 € | ||
| 100mg | 518.00 € | ||
| 500mg | 932.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Chrysoeriol
CAS:491-71-4
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows …
Formula:
C16H12O6
Purity:
98.16%
Color and Shape:
Solid
Molecular weight:
300.26
Ref: TM-TN1490
| 1mg | 47.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 176.00 € | ||
| 25mg | 351.00 € | ||
| 50mg | 519.00 € | ||
| 100mg | 739.00 € | ||
| 1mL*10mM (DMSO) | 119.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SKLB-163
CAS:1255099-06-9
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt …
Formula:
C18H16ClN3O2S2
Purity:
98.31%
Color and Shape:
Solid
Molecular weight:
405.92
Ref: TM-T26193
| 1mg | 132.00 € | ||
| 5mg | 312.00 € | ||
| 10mg | 462.00 € | ||
| 25mg | 736.00 € | ||
| 50mg | 1,054.00 € | ||
| 100mg | 1,411.00 € | ||
| 500mg | 2,756.00 € | ||
| 1mL*10mM (DMSO) | 352.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Sophocarpine
CAS:6483-15-4
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
Formula:
C15H22N2O
Purity:
98.67%
Color and Shape:
Solid
Molecular weight:
246.35
Ref: TM-T6677
| 5mg | 49.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 141.00 € | ||
| 50mg | 200.00 € | ||
| 100mg | 300.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
