MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 887 products of "MAPK"

Purity (%)

100

products per page.

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HPK1-IN-24
CAS:
- 2294966-07-5
HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].
Formula:C₁₉H₁₄FN₅
Color and Shape:Solid
Molecular weight:331.35
Ref: TM-T60973
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UC-857993
CAS:
- 487001-04-7
UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.
Formula:C₂₅H₂₂ClNO₂
Color and Shape:Solid
Molecular weight:403.9
Ref: TM-T69195
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JNK3 inhibitor-2
CAS:
- 2366264-18-6
JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.
Formula:C₂₀H₁₄N₂O₂
Color and Shape:Solid
Molecular weight:314.34
Ref: TM-T60805
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Tpl2 Kinase Inhibitor 1
CAS:
- 871307-18-5
Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.
Formula:C₂₁H₁₄ClFN₆
Purity:98%
Color and Shape:Solid
Molecular weight:404.83
Ref: TM-T17145
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SX 011
CAS:
- 309913-42-6
SX 011 is a p38α inhibitor.
Formula:C₂₆H₂₇ClFN₃O₃
Purity:98%
Color and Shape:Solid
Molecular weight:483.96
Ref: TM-T23408
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KRAS inhibitor-7
CAS:
- 2022986-68-9
KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
Formula:C₂₆H₂₇ClF₂N₆O₂
Purity:98%
Color and Shape:Solid
Molecular weight:528.98
Ref: TM-T11774
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HPK1-IN-25
CAS:
- 2403600-50-8
HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.
Formula:C₂₃H₂₅N₅O
Color and Shape:Solid
Molecular weight:387.48
Ref: TM-T61733
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KRAS G12C inhibitor 43
CAS:
- 2648808-69-7
KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50>1μM).
Formula:C₃₃H₃₅N₇O₃
Color and Shape:Solid
Molecular weight:577.68
Ref: TM-T64085
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GGTI-286 hydrochloride
CAS:
- 181141-66-2
GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).
Formula:C₂₃H₃₂ClN₃O₃S
Color and Shape:Solid
Molecular weight:466.04
Ref: TM-T62980
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SMAP-2
CAS:
- 1809068-70-9
SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.
Formula:C₂₇H₂₇F₃N₂O₄S
Purity:98%
Color and Shape:Solid
Molecular weight:532.57
Ref: TM-T12934
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HPK1-IN-26
CAS:
- 2229042-24-2
HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.
Formula:C₁₉H₂₁N₅OS
Color and Shape:Solid
Molecular weight:367.47
Ref: TM-T61437
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ZINC09659342
CAS:
- 1668604-47-4
ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).
Formula:C₂₃H₁₅F₃N₂O₄
Color and Shape:Solid
Molecular weight:440.37
Ref: TM-T62535
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NSC-658497
CAS:
- 909197-38-2
NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.
Formula:C₂₀H₁₀N₂O₆S₂
Purity:98%
Color and Shape:Solid
Molecular weight:438.43
Ref: TM-T24554
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SR 3576
CAS:
- 1164153-22-3
JNK3 inhibitor, potent and selective
Formula:C₂₇H₂₇N₅O₅
Purity:98%
Color and Shape:Solid
Molecular weight:501.53
Ref: TM-T23392
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CAY10561
CAS:
- 933786-58-4
CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.
Formula:C₂₂H₁₇Cl₂FN₄O₂
Color and Shape:Solid
Molecular weight:459.3
Ref: TM-T36672
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KRAS G12C inhibitor 22
CAS:
- 2736599-72-5
KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.
Formula:C₃₂H₄₁N₇O₂
Color and Shape:Solid
Molecular weight:555.71
Ref: TM-T63926
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Quazinone
CAS:
- 70018-51-8
Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.
Formula:C₁₁H₁₀ClN₃O
Color and Shape:Solid
Molecular weight:235.67
Ref: TM-T36547
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SB-747651A
CAS:
- 607372-46-3
SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.
Formula:C₁₆H₂₂N₈O
Purity:98%
Color and Shape:Solid
Molecular weight:342.4
Ref: TM-T28695
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EO 1428
CAS:
- 321351-00-2
p38α and p38β2 inhibitor
Formula:C₂₀H₁₆BrClN₂O
Purity:98%
Color and Shape:Solid
Molecular weight:415.71
Ref: TM-T22765
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PD 334581
CAS:
- 548756-68-9
MEK1 inhibitor
Formula:C₂₀H₁₉F₃IN₅O₂
Purity:98%
Color and Shape:Solid
Molecular weight:545.3
Ref: TM-T23129

MAPK

Found 887 products of "MAPK"

HPK1-IN-24

Ref: TM-T60973

UC-857993

Ref: TM-T69195

JNK3 inhibitor-2

Ref: TM-T60805

Tpl2 Kinase Inhibitor 1

Ref: TM-T17145

SX 011

Ref: TM-T23408

KRAS inhibitor-7

Ref: TM-T11774

HPK1-IN-25

Ref: TM-T61733

KRAS G12C inhibitor 43

Ref: TM-T64085

GGTI-286 hydrochloride

Ref: TM-T62980

SMAP-2

Ref: TM-T12934

HPK1-IN-26

Ref: TM-T61437

ZINC09659342

Ref: TM-T62535

NSC-658497

Ref: TM-T24554

SR 3576

Ref: TM-T23392

CAY10561

Ref: TM-T36672

KRAS G12C inhibitor 22

Ref: TM-T63926

Quazinone

Ref: TM-T36547

SB-747651A

Ref: TM-T28695

EO 1428

Ref: TM-T22765

PD 334581

Ref: TM-T23129