MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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Cobimetinib racemate
CAS:934662-91-6
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also …
Formula:
C21H21F3IN3O2
Purity:
98.00% - 99.71%
Color and Shape:
Solid
Molecular weight:
531.31
Ref: TM-T22677
| 2mg | 185.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
ARS-1323
CAS:1698024-73-5
ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.
Formula:
C21H17ClF2N4O2
Purity:
98.88%
Color and Shape:
Solid
Molecular weight:
430.84
Ref: TM-T10375
| 1mg | 42.00 € | ||
| 5mg | 82.00 € | ||
| 10mg | 122.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 236.00 € | ||
| 100mg | 342.00 € | ||
| 1mL*10mM (DMSO) | 91.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Raf inhibitor 3
CAS:1662682-11-2
Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 …
Formula:
C18H19FN8O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
430.46
Ref: TM-T79813
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Org OD 02-0
CAS:13258-85-0
10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) …
Formula:
C22H30O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
326.47
Ref: TM-T81598
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Feb 2025
BI-2493
CAS:2937344-16-4
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity …
Formula:
C24H27N7OS
Purity:
97.03% - 99.49%
Color and Shape:
Soild
Molecular weight:
461.58
Ref: TM-T72061
| 1mg | 587.00 € | ||
| 5mg | 1,444.00 € | ||
| 10mg | 2,300.00 € | ||
| 25mg | 3,413.00 € | ||
| 50mg | 4,545.00 € | ||
| 100mg | 6,149.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
B-Raf IN 15
CAS:832107-31-0
B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be …
Formula:
C19H15N3OS
Purity:
98%
Color and Shape:
Solid
Molecular weight:
333.41
Ref: TM-T78183
| 1mg | 56.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 185.00 € | ||
| 25mg | 323.00 € | ||
| 1mL*10mM (DMSO) | 136.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
KRAS G12C inhibitor 61
CAS:2300967-40-0
KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA …
Formula:
C31H33ClFN7O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
590.09
Ref: TM-T79808
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Feb 2025
p38-α MAPK-IN-1
CAS:443913-15-3
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM …
Formula:
C27H35N5O3
Purity:
99.52%
Color and Shape:
Solid
Molecular weight:
477.6
Ref: TM-T12347
| 1mg | 87.00 € | ||
| 5mg | 178.00 € | ||
| 10mg | 278.00 € | ||
| 25mg | 513.00 € | ||
| 50mg | 768.00 € | ||
| 100mg | 1,154.00 € | ||
| 500mg | 2,249.00 € | ||
| 1mL*10mM (DMSO) | 186.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
AY 77
CAS:1835734-92-3
AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer …
Formula:
C21H32N4O4
Purity:
99.7%
Color and Shape:
Solid
Molecular weight:
404.5
Ref: TM-T41190
| 1mg | 637.00 € | ||
| 5mg | 1,375.00 € | ||
| 10mg | 1,854.00 € | ||
| 25mg | 2,747.00 € | ||
| 50mg | 3,720.00 € | ||
| 100mg | 5,001.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
AZD4747
CAS:2489226-14-2
AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the …
Formula:
C24H22ClFN2O3
Purity:
99.36%
Color and Shape:
Liquid
Molecular weight:
440.89
Ref: TM-T79213
| 1mg | 248.00 € | ||
| 5mg | 606.00 € | ||
| 10mg | 918.00 € | ||
| 25mg | 2,026.00 € | ||
| 50mg | 3,243.00 € | ||
| 100mg | 5,222.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
p38 Kinase inhibitor 4
CAS:13142-47-7
Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 …
Formula:
C12H9Cl2N3O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
282.13
Ref: TM-T79028
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Feb 2025
Kras4B G12D-IN-1
CAS:2042365-85-3
Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein …
Formula:
C16H21ClN2O4S
Purity:
99.75%
Color and Shape:
Liquid
Molecular weight:
372.87
Ref: TM-T78170
| 2mg | 96.00 € | ||
| 5mg | 150.00 € | ||
| 10mg | 238.00 € | ||
| 25mg | 483.00 € | ||
| 50mg | 772.00 € | ||
| 100mg | 1,175.00 € | ||
| 500mg | 2,359.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
(R)-VX-11e
CAS:1680187-43-2
'(R)-VX-11e (Compound 1) functions as an inhibitor of ERK2 [1].'
Formula:
C24H20Cl2FN5O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
500.35
Ref: TM-T78143
| 2mg | 73.00 € |
Estimated delivery in United States, on Tuesday 4 Feb 2025
MK-8353
CAS:1184173-73-6
MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 …
Formula:
C37H41N9O3S
Purity:
96.15% - 99.89%
Color and Shape:
Solid
Molecular weight:
691.84
Ref: TM-T12069
| 1mg | 79.00 € | ||
| 5mg | 153.00 € | ||
| 10mg | 268.00 € | ||
| 25mg | 451.00 € | ||
| 50mg | 655.00 € | ||
| 100mg | 933.00 € | ||
| 1mL*10mM (DMSO) | 229.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Pan-RAS-IN-1
CAS:1835283-94-7
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their …
Formula:
C36H41Cl2F3N6O2
Purity:
98.57%
Color and Shape:
Solid
Molecular weight:
717.65
Ref: TM-T16432
| 1mg | 80.00 € | ||
| 2mg | 96.00 € | ||
| 5mg | 144.00 € | ||
| 10mg | 215.00 € | ||
| 25mg | 437.00 € | ||
| 50mg | 655.00 € | ||
| 100mg | 931.00 € | ||
| 500mg | 1,866.00 € | ||
| 1mL*10mM (DMSO) | 220.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
BMS-214662
CAS:195987-41-8
BMS-214662: potent, selective farnesyl transferase inhibitor; triggers apoptosis in CML stem cells; antitumor effects.
Formula:
C25H23N5O2S2
Color and Shape:
Solid
Molecular weight:
489.61
Ref: TM-T10567
| 25mg | 2,106.00 € | ||
| 50mg | 2,789.00 € | ||
| 100mg | 3,744.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
12(S)-HETE
CAS:54397-83-0
12(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid with mitogenic effects on cancer cell proliferation.
Formula:
C20H32O3
Color and Shape:
Liquid
Molecular weight:
320.47
Ref: TM-T37047
| 10µg | 404.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
SKLB646
CAS:1970149-05-3
SKLB646 is an orally active multitarget kinase inhibitor that exhibits potent suppression of several kinases. …
Formula:
C28H26F3N7O
Color and Shape:
Liquid
Molecular weight:
533.55
Ref: TM-T200104
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
KU004
CAS:1260401-93-1
KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human …
Formula:
C29H27ClFN4O2P
Color and Shape:
Liquid
Molecular weight:
548.98
Ref: TM-T89998
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
RGT-018
CAS:2794934-49-7
RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity …
Formula:
C27H24F3N7O2
Color and Shape:
Liquid
Molecular weight:
535.52
Ref: TM-T89897
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
