MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 922 products for "MAPK".
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HPK1-IN-28
CAS:HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.Formula:C25H22F3N5O4Color and Shape:SolidMolecular weight:513.47JTP-70902
CAS:JTP-70902 is a protein kinase inhibitor with antineoplastic activity.Formula:C24H21BrFN5O5SColor and Shape:SolidMolecular weight:590.42SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurity:99.38% - 99.71%Color and Shape:SolidMolecular weight:490.559JNK3 inhibitor-2
CAS:JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.Formula:C20H14N2O2Color and Shape:SolidMolecular weight:314.34EO 1428
CAS:p38α and p38β2 inhibitorFormula:C20H16BrClN2OPurity:98%Color and Shape:SolidMolecular weight:415.71GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purity:99.62%Color and Shape:SolidMolecular weight:334.37RMM-46
CAS:RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.Formula:C24H26N4O5Purity:98.15%Color and Shape:Yellow SolidMolecular weight:450.49Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurity:98.31%Color and Shape:Yellow SolidMolecular weight:454.5269K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3 covalently binds G12C mutant cysteine, locking K-Ras in an inactive GDP-bound state and blocking MAPK/ERK signaling.Formula:C21H19Cl3N2O3Color and Shape:SolidMolecular weight:453.746UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Color and Shape:SolidMolecular weight:403.9GGTI-286
CAS:GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.Formula:C23H31N3O3SColor and Shape:SolidMolecular weight:429.58Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formula:C26H28BrF3N4O2Purity:98%Color and Shape:SolidMolecular weight:565.43TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormula:C17H15F3N2O4Color and Shape:SolidMolecular weight:368.31VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Formula:C19H19FN2O2Color and Shape:SolidMolecular weight:326.36SR 3576
CAS:SR 3576 is an aminopyrazole-type JNK inhibitor with an IC₅₀ of 7 nM for JNK3 and a selectivity of more than 2,800-fold towards p38; it can be used in studies relating to JNK signalling.Formula:C27H27N5O5Purity:99.83%Color and Shape:SolidMolecular weight:501.53GNE-1858
CAS:GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).Formula:C21H26F2N8Purity:99.36%Color and Shape:SolidMolecular weight:428.4815SB-747651A
CAS:SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.Formula:C16H22N8OPurity:98%Color and Shape:SolidMolecular weight:342.4HPK1-IN-24
CAS:HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].Formula:C19H14FN5Color and Shape:SolidMolecular weight:331.35ML 3403
CAS:p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.Formula:C23H21FN4SColor and Shape:SolidMolecular weight:404.5Avutometinib potassium
CAS:Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.Formula:C21H17FKN5O5SColor and Shape:SolidMolecular weight:509.55
