MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 887 products of "MAPK"

Purity (%)

100

products per page.

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p38α inhibitor 2
CAS:
- 1095003-80-7
P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.
Formula:C₂₇H₃₃N₅O₃
Color and Shape:Solid
Molecular weight:475.58
Ref: TM-T36012
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pan-KRAS-IN-16
CAS:
- 2368246-78-8
3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.
Formula:C₂₄H₂₆N₂O₃
Purity:98%
Color and Shape:Solid
Molecular weight:390.47
Ref: TM-T9184
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B-Raf IN 6
CAS:
- 2648698-34-2
B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.
Formula:C₂₄H₂₁F₃N₆O₂S₂
Color and Shape:Solid
Molecular weight:546.59
Ref: TM-T63855
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(R)-CE3F4
CAS:
- 1593478-56-8
(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),
Formula:C₁₁H₁₀Br₂FNO
Color and Shape:Solid
Molecular weight:351.01
Ref: TM-T12616
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SR-3737
CAS:
- 1164153-37-0
SR-3737 is potent both JNK3 and p38 inhibitor.
Formula:C₂₉H₂₅FN₄O₄
Purity:98%
Color and Shape:Solid
Molecular weight:512.53
Ref: TM-T24829
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TOPK-p38/JNK-IN-1
CAS:
- 2745108-35-2
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO
Formula:C₁₇H₁₅F₃N₂O₄
Color and Shape:Solid
Molecular weight:368.31
Ref: TM-T61440
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B-Raf IN 7
CAS:
- 2477725-07-6
"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."
Formula:C₁₅H₁₆N₆O₃
Color and Shape:Solid
Molecular weight:328.33
Ref: TM-T60933
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KB-5246
CAS:
- 119474-55-4
KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
Formula:C₁₈H₁₇ClFN₃O₄S
Purity:98%
Color and Shape:Solid
Molecular weight:425.86
Ref: TM-T11744
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KRas G12C inhibitor 4
CAS:
- 2206736-07-2
KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
Formula:C₃₃H₃₈ClN₇O₂
Purity:98%
Color and Shape:Solid
Molecular weight:600.15
Ref: TM-T11779
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Avutometinib potassium
CAS:
- 946128-90-1
Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.
Formula:C₂₁H₁₇FKN₅O₅S
Color and Shape:Solid
Molecular weight:509.55
Ref: TM-T68270
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3,4-Dephostatin
CAS:
- 173043-84-0
3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.
Formula:C₇H₈N₂O₃
Color and Shape:Solid
Molecular weight:168.15
Ref: TM-T70232
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ERK5-IN-3
CAS:
- 1888305-85-8
ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).
Formula:C₂₄H₂₃Cl₂FN₄O₂
Color and Shape:Solid
Molecular weight:489.37
Ref: TM-T63268
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Ras modulator-1
CAS:
- 623935-08-0
Ras modulator-1 is a modulator of Ras.
Formula:C₂₉H₂₁N₅O₄S
Color and Shape:Solid
Molecular weight:535.57
Ref: TM-T72774
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KRas G12C inhibitor 3
CAS:
- 2206735-75-1
KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
Formula:C₃₂H₃₆ClN₇O₂
Purity:98%
Color and Shape:Solid
Molecular weight:586.13
Ref: TM-T11778
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MW108
CAS:
- 1454658-89-9
MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.
Formula:C₂₁H₁₉ClN₄
Color and Shape:Solid
Molecular weight:362.86
Ref: TM-T24510
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(S)-CCG-1423
(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.
Formula:C₁₈H₁₃ClF₆N₂O₃
Purity:98%
Color and Shape:Solid
Molecular weight:454.8
Ref: TM-T23296
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K-Ras G12C-IN-3
CAS:
- 1629268-19-4
K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.
Formula:C₂₁H₁₉Cl₃N₂O₃
Color and Shape:Solid
Molecular weight:453.75
Ref: TM-T11737
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ML 3403
CAS:
- 549505-65-9
p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.
Formula:C₂₃H₂₁FN₄S
Color and Shape:Solid
Molecular weight:404.5
Ref: TM-T37590
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CCG-232601
CAS:
- 1922099-21-5
CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.
Formula:C₂₄H₂₀ClF₂N₃O₂
Purity:98%
Color and Shape:Solid
Molecular weight:455.88
Ref: TM-T26967
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Tinlorafenib
CAS:
- 2573781-75-4
Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.
Formula:C₁₉H₁₉ClF₂N₄O₃S
Color and Shape:Solid
Molecular weight:456.89
Ref: TM-T62841

MAPK

Found 887 products of "MAPK"

p38α inhibitor 2

Ref: TM-T36012

pan-KRAS-IN-16

Ref: TM-T9184

B-Raf IN 6

Ref: TM-T63855

(R)-CE3F4

Ref: TM-T12616

SR-3737

Ref: TM-T24829

TOPK-p38/JNK-IN-1

Ref: TM-T61440

B-Raf IN 7

Ref: TM-T60933

KB-5246

Ref: TM-T11744

KRas G12C inhibitor 4

Ref: TM-T11779

Avutometinib potassium

Ref: TM-T68270

3,4-Dephostatin

Ref: TM-T70232

ERK5-IN-3

Ref: TM-T63268

Ras modulator-1

Ref: TM-T72774

KRas G12C inhibitor 3

Ref: TM-T11778

MW108

Ref: TM-T24510

(S)-CCG-1423

Ref: TM-T23296

K-Ras G12C-IN-3

Ref: TM-T11737

ML 3403

Ref: TM-T37590

CCG-232601

Ref: TM-T26967

Tinlorafenib

Ref: TM-T62841