MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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Refametinib R enantiomer
CAS:923032-38-6
Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 …
Formula:
C19H20F3IN2O5S
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
572.34
Ref: TM-T12697
| 1mg | 91.00 € | ||
| 5mg | 195.00 € | ||
| 10mg | 289.00 € | ||
| 25mg | 544.00 € | ||
| 50mg | 729.00 € | ||
| 100mg | 1,016.00 € | ||
| 500mg | 2,037.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
PF-03715455
CAS:1056164-52-3
PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity …
Formula:
C35H34ClN7O3S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
700.27
Ref: TM-T16477
| 5mg | 4,654.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
SJ-C1044
CAS:2121503-76-0
SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type …
Formula:
C25H14F7N7O
Color and Shape:
Liquid
Molecular weight:
561.41
Ref: TM-T200357
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
Emprumapimod
CAS:765914-60-1
Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; …
Formula:
C24H29F2N5O3
Purity:
100% - 99.21%
Color and Shape:
Liquid
Molecular weight:
473.52
Ref: TM-T63067
| 1mg | 246.00 € | ||
| 5mg | 502.00 € | ||
| 10mg | 801.00 € | ||
| 50mg | 1,603.00 € | ||
| 100mg | 2,162.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
ERK2 IN-1
CAS:1093061-47-2
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
Formula:
C36H34FN7O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
647.76
Ref: TM-T11228
| 25mg | 2,106.00 € | ||
| 50mg | 2,785.00 € | ||
| 100mg | 3,739.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
XMU-MP-9
CAS:2251130-41-1
XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of …
Formula:
C19H13ClFN3OS
Color and Shape:
Liquid
Molecular weight:
385.84
Ref: TM-T200189
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
EBI-1051
CAS:1801896-05-8
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
Formula:
C18H15F2IN2O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
504.22
Ref: TM-T15193
| 25mg | 2,245.00 € | ||
| 50mg | 2,972.00 € | ||
| 100mg | 4,019.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
KRAS inhibitor-8
CAS:2022986-70-3
KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
Formula:
C26H24ClF4N5O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
565.95
Ref: TM-T11775
| 25mg | 2,106.00 € | ||
| 50mg | 2,785.00 € | ||
| 100mg | 3,739.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
KRAS G12C inhibitor 15
CAS:2349393-21-9
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
Formula:
C25H21ClF2N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
498.91
Ref: TM-T11769
| 25mg | 2,941.00 € | ||
| 50mg | 3,872.00 € | ||
| 100mg | 5,985.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
KRas G12C inhibitor 2
CAS:2206735-61-5
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
Formula:
C32H37N7O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
567.68
Ref: TM-T11777
| 25mg | 2,377.00 € | ||
| 50mg | 3,152.00 € | ||
| 100mg | 4,289.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
DOR agonist 2
CAS:1212540-02-7
Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the …
Formula:
C29H26N2O3
Color and Shape:
Liquid
Molecular weight:
450.53
Ref: TM-T200382
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
ERK-IN-2
CAS:2743576-56-7
ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than …
Formula:
C16H18ClN5O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
347.8
Ref: TM-T11225
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
IHMT-RAF-128
CAS:2479289-15-9
IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor …
Formula:
C27H24F3N5O2
Color and Shape:
Liquid
Molecular weight:
507.51
Ref: TM-T89984
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
LSN3074753
CAS:1455031-68-1
LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound …
Formula:
C24H30FN5O2
Color and Shape:
Liquid
Molecular weight:
439.53
Ref: TM-T89906
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
Ergosterol peroxide
CAS:2061-64-5
Ergosterol peroxide inhibits osteoclasts, has antiviral/antitumor effects, stimulates Foxo3a, and may prevent renal fibrosis.
Formula:
C28H44O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
428.65
Ref: TM-TMA1743
| 1mg | 361.00 € | ||
| 5mg | 1,404.00 € | ||
| 500µg | 188.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
NHTD
CAS:2540915-70-4
NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, …
Formula:
C24H26N2O5
Color and Shape:
Liquid
Molecular weight:
422.47
Ref: TM-T200095
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
J-104871
CAS:191088-19-4
J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with …
Formula:
C38H32N2O12
Purity:
98%
Color and Shape:
Solid
Molecular weight:
708.67
Ref: TM-T24188
| 1mg | 182.00 € | ||
| 5mg | 450.00 € | ||
| 10mg | 644.00 € | ||
| 25mg | 1,005.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
KRAS inhibitor-31
CAS:2920695-77-6
KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of …
Formula:
C33H30F3N5O4
Color and Shape:
Liquid
Molecular weight:
617.62
Ref: TM-T200064
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 4 Mar 2025
Rineterkib
CAS:1715025-32-3
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
Formula:
C26H27BrF3N5O2
Purity:
98.4%
Color and Shape:
Solid
Molecular weight:
578.42
Ref: TM-T11224
| 1mg | 96.00 € | ||
| 5mg | 190.00 € | ||
| 10mg | 357.00 € | ||
| 25mg | 604.00 € | ||
| 50mg | 860.00 € | ||
| 100mg | 1,170.00 € | ||
| 1mL*10mM (DMSO) | 252.00 € |
Estimated delivery in United States, on Tuesday 18 Mar 2025
Garsorasib
CAS:2559761-14-5
Garsorasib is an effective KRAS G12C inhibitor (IC50 = 10 nM) and can be used …
Formula:
C32H32F2N8O2
Purity:
98.99%
Color and Shape:
Solid
Molecular weight:
598.65
Ref: TM-T40186
| 1mg | Discontinued | Request information | |
| 2mg | Discontinued | Request information | |
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information | |
| 1ml*10 (DMSO) | Discontinued | Request information | |
| 1mL*10mM (DMSO) | Discontinued | Request information |
