MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; …
Formula:
C29H29Cl2N5O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
534.48
Ref: TM-T10298L2
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
BI-2493
CAS:2937344-16-4
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity …
Formula:
C24H27N7OS
Purity:
97.03% - 99.51%
Color and Shape:
Soild
Molecular weight:
461.58
Ref: TM-T72061
| 1mg | 597.00 € | ||
| 5mg | 1,473.00 € | ||
| 10mg | 2,118.00 € | ||
| 25mg | 2,832.00 € | ||
| 50mg | 3,771.00 € | ||
| 100mg | 6,080.00 € | ||
| 1mL*10mM (DMSO) | 1,634.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
SOS1-IN-16
CAS:2930763-85-0
SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 …
Formula:
C30H31F3N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
552.59
Ref: TM-T79183
| 25mg | 1,730.00 € | ||
| 50mg | 2,262.00 € | ||
| 100mg | 2,945.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
AY 77
CAS:1835734-92-3
AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer …
Formula:
C21H32N4O4
Purity:
99.7%
Color and Shape:
Solid
Molecular weight:
404.5
Ref: TM-T41190
| 1mg | 391.00 € | ||
| 5mg | 843.00 € | ||
| 10mg | 1,130.00 € | ||
| 25mg | 1,681.00 € | ||
| 50mg | 2,270.00 € | ||
| 100mg | 3,068.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
KRAS G12C inhibitor 32
CAS:2756739-00-9
KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor …
Formula:
C29H30Cl3FN6O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
635.94
Ref: TM-T72335
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
XRP44X
CAS:729605-21-4
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Formula:
C21H21ClN4O
Purity:
97.51%
Color and Shape:
Solid
Molecular weight:
380.87
Ref: TM-T20759
| 10mg | 55.00 € | ||
| 25mg | 80.00 € | ||
| 50mg | 111.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
KRAS G12D modulator-1
CAS:2883034-05-5
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging …
Formula:
C30H36FN5O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
549.64
Ref: TM-T79072
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 11 Jul 2025
Glycinexylidide
CAS:18865-38-8
Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting …
Formula:
C10H14N2O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
178.23
Ref: TM-T80638
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 11 Jul 2025
Kras4B G12D-IN-1
CAS:2042365-85-3
Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein …
Formula:
C16H21ClN2O4S
Purity:
99.75%
Color and Shape:
Solid
Molecular weight:
372.87
Ref: TM-T78170
| 2mg | 87.00 € | ||
| 5mg | 153.00 € | ||
| 10mg | 243.00 € | ||
| 25mg | 492.00 € | ||
| 50mg | 787.00 € | ||
| 100mg | 1,198.00 € | ||
| 500mg | 2,403.00 € | ||
| 1mL*10mM (DMSO) | 170.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
(R)-VX-11e
CAS:1680187-43-2
(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to …
Formula:
C24H20Cl2FN5O2
Purity:
98.73%
Color and Shape:
Solid
Molecular weight:
500.35
Ref: TM-T78143
| 2mg | 74.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
SOS1/KRAS-IN-1
CAS:2836330-34-6
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study …
Formula:
C24H26F3N5O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
457.49
Ref: TM-T79162
| 25mg | 1,872.00 € | ||
| 50mg | 2,452.00 € | ||
| 100mg | 3,230.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
KRas G12C inhibitor 1
CAS:2158297-28-8
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
Formula:
C31H38N6O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
542.67
Ref: TM-T11776
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
JNK3 inhibitor-3
CAS:2873465-25-7
JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, …
Formula:
C26H25N7O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
467.52
Ref: TM-T72714
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
ARS-1323-alkyne
CAS:2436544-27-1
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C …
Formula:
C28H27ClF2N6O3
Purity:
98.00% - 99%
Color and Shape:
Solid
Molecular weight:
569
Ref: TM-T10374
| 1mg | 167.00 € | ||
| 5mg | 442.00 € | ||
| 10mg | 745.00 € | ||
| 25mg | 1,103.00 € | ||
| 50mg | 1,491.00 € | ||
| 100mg | 2,015.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
KRAS G12C inhibitor 13
CAS:2241719-75-3
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
Formula:
C40H46F3N7O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
745.83
Ref: TM-T11767
| 25mg | 2,015.00 € | ||
| 50mg | 2,642.00 € | ||
| 100mg | 3,515.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
KRAS G12C inhibitor 17
CAS:2349393-04-8
KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.
Formula:
C24H20ClF2N3O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
471.88
Ref: TM-T11771
| 25mg | 1,872.00 € | ||
| 50mg | 2,452.00 € | ||
| 100mg | 3,230.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows …
Formula:
C29H28ClN5O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
498.02
Ref: TM-T10298
| 25mg | 1,654.00 € | ||
| 50mg | 2,300.00 € | ||
| 100mg | 2,793.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
Raf inhibitor 3
CAS:1662682-11-2
Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 …
Formula:
C18H19FN8O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
430.46
Ref: TM-T79813
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 11 Jul 2025
AZD4747
CAS:2489226-14-2
AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the …
Formula:
C24H22ClFN2O3
Purity:
99.36%
Color and Shape:
Solid
Molecular weight:
440.89
Ref: TM-T79213
| 1mg | 253.00 € | ||
| 5mg | 620.00 € | ||
| 10mg | 938.00 € | ||
| 25mg | 2,072.00 € | ||
| 50mg | 3,315.00 € | ||
| 100mg | 5,339.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
MEK-IN-6 hydrate
CAS:2845153-35-5
MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in …
Formula:
C18H22FN3O5S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
411.45
Ref: TM-T79048
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
