MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 887 products of "MAPK"

Purity (%)

100

products per page.

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PHT-7.3
CAS:
- 1614225-93-2
PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitor
Formula:C₂₄H₂₃N₃O₃S
Purity:98%
Color and Shape:Solid
Molecular weight:433.52
Ref: TM-T12453
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BRAF V600E/CRAF-IN-1
CAS:
- 2499499-56-6
BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.
Formula:C₂₅H₁₇F₆N₃O₂
Color and Shape:Solid
Molecular weight:505.41
Ref: TM-T63448
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KRAS inhibitor-6
CAS:
- 2022986-61-2
KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
Formula:C₂₇H₃₀ClF₂N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:546.01
Ref: TM-T11773
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(R)-STU104
CAS:
- 2767124-77-4
(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.
Formula:C₁₈H₁₈O₄
Purity:98.91% - 99.42%
Color and Shape:Solid
Molecular weight:298.33
Ref: TM-T60657
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REDX05358
CAS:
- 1884226-20-3
REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.
Formula:C₂₆H₂₁ClN₄O₃
Color and Shape:Solid
Molecular weight:472.92
Ref: TM-T28510
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KRAS inhibitor-3
CAS:
- 900897-56-5
KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.
Formula:C₂₅H₂₇N₅O
Color and Shape:Solid
Molecular weight:413.51
Ref: TM-T72659
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Spiclomazine HCl
CAS:
- 27007-85-8
Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.
Formula:C₂₂H₂₅Cl₂N₃OS₂
Color and Shape:Solid
Molecular weight:482.49
Ref: TM-T34695
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PF-04880594
CAS:
- 1111636-35-1
PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].
Formula:C₁₉H₁₆F₂N₈
Color and Shape:Solid
Molecular weight:394.38
Ref: TM-T21602
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KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.
Formula:C₃₆H₃₉ClN₈O₂
Color and Shape:Solid
Molecular weight:651.2
Ref: TM-T72348
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KRAS G12C inhibitor 31
CAS:
- 2752352-86-4
KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.
Formula:C₂₅H₂₂ClFN₆O₃
Color and Shape:Solid
Molecular weight:508.93
Ref: TM-T63502
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Nek2-IN-6
CAS:
- 2410376-96-2
Nek2-IN-6 inhibitor .
Formula:C₃₃H₃₃F₃N₆O₄S
Color and Shape:Solid
Molecular weight:666.71
Ref: TM-T73287
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L-167307
CAS:
- 188352-45-6
L-167307 is a p38 kinase inhibitor.
Formula:C₂₂H₁₇FN₂OS
Purity:98%
Color and Shape:Solid
Molecular weight:376.45
Ref: TM-T24368
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KRAS4b-IN-D14
CAS:
- 924249-06-9
KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.
Formula:C₂₄H₂₄ClN₅O₄
Color and Shape:Solid
Molecular weight:481.93
Ref: TM-T71717
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HPK1-IN-15
CAS:
- 2201098-03-3
HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.
Formula:C₂₄H₂₁ClF₃N₅
Color and Shape:Solid
Molecular weight:471.91
Ref: TM-T63046
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KRAS G12D inhibitor 13
CAS:
- 2648552-62-7
KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).
Formula:C₃₁H₃₃F₂N₇O₃
Color and Shape:Solid
Molecular weight:589.64
Ref: TM-T64178
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KRAS G12C inhibitor 42
CAS:
- 2454488-02-7
KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)
Formula:C₃₃H₃₄FN₇O₂
Color and Shape:Solid
Molecular weight:579.67
Ref: TM-T64095
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p38-α MAPK-IN-4
CAS:
- 2396754-57-5
p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.
Formula:C₁₇H₁₃BrN₂O
Color and Shape:Solid
Molecular weight:341.2
Ref: TM-T61091
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LCRF-0004
CAS:
- 1229611-73-7
LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.
Formula:C₂₈H₁₈F₄N₆O₂S
Color and Shape:Solid
Molecular weight:578.54
Ref: TM-T71177
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KRAS G12C inhibitor 39
CAS:
- 2326522-16-9
KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.
Formula:C₃₇H₄₃N₉O₂
Color and Shape:Solid
Molecular weight:645.8
Ref: TM-T72342
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CBS-3595
CAS:
- 908380-97-2
CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.
Formula:C₁₈H₁₇FN₄O₂S
Purity:98%
Color and Shape:Solid
Molecular weight:372.42
Ref: TM-T26964

MAPK

Found 887 products of "MAPK"

PHT-7.3

Ref: TM-T12453

BRAF V600E/CRAF-IN-1

Ref: TM-T63448

KRAS inhibitor-6

Ref: TM-T11773

(R)-STU104

Ref: TM-T60657

REDX05358

Ref: TM-T28510

KRAS inhibitor-3

Ref: TM-T72659

Spiclomazine HCl

Ref: TM-T34695

PF-04880594

Ref: TM-T21602

KRAS G12C inhibitor 48

Ref: TM-T72348

KRAS G12C inhibitor 31

Ref: TM-T63502

Nek2-IN-6

Ref: TM-T73287

L-167307

Ref: TM-T24368

KRAS4b-IN-D14

Ref: TM-T71717

HPK1-IN-15

Ref: TM-T63046

KRAS G12D inhibitor 13

Ref: TM-T64178

KRAS G12C inhibitor 42

Ref: TM-T64095

p38-α MAPK-IN-4

Ref: TM-T61091

LCRF-0004

Ref: TM-T71177

KRAS G12C inhibitor 39

Ref: TM-T72342

CBS-3595

Ref: TM-T26964