MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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BI-0474
CAS:2750570-55-7
BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, …
Formula:
C30H37N9O2S
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
587.74
Ref: TM-T69529
| 1mg | 369.00 € | ||
| 5mg | 777.00 € | ||
| 10mg | 1,169.00 € | ||
| 25mg | 1,882.00 € | ||
| 50mg | 2,593.00 € | ||
| 1mL*10mM (DMSO) | 740.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
Exarafenib
CAS:2639957-39-2
Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer …
Formula:
C26H34F3N5O3
Purity:
98.36% - 99.39%
Color and Shape:
Liquid
Molecular weight:
521.58
Ref: TM-T63644
| 1mg | 129.00 € | ||
| 5mg | 311.00 € | ||
| 10mg | 533.00 € | ||
| 25mg | 802.00 € | ||
| 50mg | 1,035.00 € | ||
| 100mg | 1,415.00 € | ||
| 500mg | 2,832.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
JWG-071
CAS:2250323-50-1
JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and …
Formula:
C34H44N8O3
Purity:
98.33%
Color and Shape:
Solid
Molecular weight:
612.77
Ref: TM-T14547
| 1mg | 70.00 € | ||
| 5mg | 153.00 € | ||
| 10mg | 185.00 € | ||
| 25mg | 283.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 197.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
PROTAC KRAS G12C degrader-3
CAS:2768099-51-8
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized …
Formula:
C63H75ClN14O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
1159.81
Ref: TM-T79148
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 11 Jul 2025
pan-KRAS-IN-3
CAS:2875116-29-1
Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].
Formula:
C33H32F3N5O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
587.63
Ref: TM-T79814
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 11 Jul 2025
p38 MAPK-IN-1
CAS:1006378-90-0
p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory …
Formula:
C21H14F2N2O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
348.35
Ref: TM-T16424
| 2mg | 188.00 € | ||
| 5mg | 329.00 € | ||
| 25mg | 1,084.00 € | ||
| 50mg | 1,415.00 € | ||
| 100mg | 1,890.00 € | ||
| 1mL*10mM (DMSO) | 363.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
KRAS G12C inhibitor 59
CAS:2914919-88-1
KRAS G12C Inhibitor 59 is a compound with anticancer properties.
Formula:
C32H39F6N7O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
715.69
Ref: TM-T79150
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 11 Jul 2025
p38-α MAPK-IN-1
CAS:443913-15-3
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM …
Formula:
C27H35N5O3
Purity:
99.52%
Color and Shape:
Solid
Molecular weight:
477.6
Ref: TM-T12347
| 1mg | 88.00 € | ||
| 5mg | 180.00 € | ||
| 10mg | 281.00 € | ||
| 25mg | 520.00 € | ||
| 50mg | 777.00 € | ||
| 100mg | 1,169.00 € | ||
| 200mg | 1,568.00 € | ||
| 500mg | 2,337.00 € | ||
| 1mL*10mM (DMSO) | 188.00 € |
Estimated delivery in United States, on Friday 11 Jul 2025
MK-8353
CAS:1184173-73-6
MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 …
Formula:
C37H41N9O3S
Purity:
96.15% - 99.89%
Color and Shape:
Solid
Molecular weight:
691.84
Ref: TM-T12069
| 1mg | 81.00 € | ||
| 5mg | 156.00 € | ||
| 10mg | 271.00 € | ||
| 25mg | 620.00 € | ||
| 50mg | 938.00 € | ||
| 100mg | 1,454.00 € | ||
| 1mL*10mM (DMSO) | 230.00 € |
Estimated delivery in United States, on Friday 25 Jul 2025
Pan-RAS-IN-1
CAS:1835283-94-7
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their …
Formula:
C36H41Cl2F3N6O2
Purity:
98.57%
Color and Shape:
Solid
Molecular weight:
717.65
Ref: TM-T16432
| 1mg | 80.00 € | ||
| 2mg | 97.00 € | ||
| 5mg | 144.00 € | ||
| 10mg | 216.00 € | ||
| 25mg | 439.00 € | ||
| 50mg | 660.00 € | ||
| 100mg | 938.00 € | ||
| 500mg | 1,882.00 € | ||
| 1mL*10mM (DMSO) | 221.00 € |
Estimated delivery in United States, on Friday 25 Jul 2025
Lambertellin
CAS:28980-51-0
Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects …
Formula:
C14H8O5
Color and Shape:
Liquid
Molecular weight:
256.21
Ref: TM-T201402
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 8 Aug 2025
ERK2 IN-1
CAS:1093061-47-2
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
Formula:
C36H34FN7O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
647.76
Ref: TM-T11228
| 25mg | 2,870.00 € | ||
| 50mg | 3,781.00 € | ||
| 100mg | 5,225.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
J-104871
CAS:191088-19-4
J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with …
Formula:
C38H32N2O12
Purity:
98%
Color and Shape:
Solid
Molecular weight:
708.67
Ref: TM-T24188
| 1mg | 185.00 € | ||
| 5mg | 459.00 € | ||
| 10mg | 657.00 € | ||
| 25mg | 1,026.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
KRas G12C inhibitor 2
CAS:2206735-61-5
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
Formula:
C32H37N7O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
567.68
Ref: TM-T11777
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
Coelogin
CAS:82358-31-4
Coelogin is an orally effective bone-protective agent that activates ER-Erk and Akt-dependent signaling pathways, thereby …
Formula:
C17H16O5
Color and Shape:
Liquid
Molecular weight:
300.31
Ref: TM-T201752
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 8 Aug 2025
Claturafenib
CAS:2754408-94-9
Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination …
Formula:
C18H15Cl2F2N5O3S
Color and Shape:
Solid
Molecular weight:
490.31
Ref: TM-T201081
| 1mg | 88.00 € | ||
| 5mg | 183.00 € | ||
| 10mg | 269.00 € | ||
| 25mg | 454.00 € | ||
| 50mg | 663.00 € | ||
| 1mL*10mM (DMSO) | 182.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
PF-03715455
CAS:1056164-52-3
PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity …
Formula:
C35H34ClN7O3S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
700.27
Ref: TM-T16477
| 25mg | 2,585.00 € | ||
| 50mg | 3,402.00 € | ||
| 100mg | 4,655.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
XMU-MP-9
CAS:2251130-41-1
XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of …
Formula:
C19H13ClFN3OS
Color and Shape:
Solid
Molecular weight:
385.84
Ref: TM-T200189
| 25mg | 1,539.00 € | ||
| 50mg | 1,941.00 € | ||
| 100mg | 2,451.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
Refametinib R enantiomer
CAS:923032-38-6
Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 …
Formula:
C19H20F3IN2O5S
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
572.34
Ref: TM-T12697
| 1mg | 93.00 € | ||
| 5mg | 200.00 € | ||
| 10mg | 294.00 € | ||
| 25mg | 557.00 € | ||
| 50mg | 742.00 € | ||
| 100mg | 1,035.00 € | ||
| 500mg | 2,072.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
KRAS G12C inhibitor 15
CAS:2349393-21-9
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
Formula:
C25H21ClF2N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
498.91
Ref: TM-T11769
| 25mg | 2,015.00 € | ||
| 50mg | 2,642.00 € | ||
| 100mg | 3,515.00 € |
Estimated delivery in United States, on Friday 8 Aug 2025
