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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • Anti-inflammatory agent 33
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    Anti-inflammatory agent 33

    CAS:
    <p>Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.</p>
    Formula:C22H15N3O5S
    Color and Shape:Solid
    Molecular weight:433.44

    Ref: TM-T72202

  • RSK2-IN-3
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    RSK2-IN-3

    CAS:
    <p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>
    Formula:C24H26N4O5
    Color and Shape:Solid
    Molecular weight:450.49

    Ref: TM-T62718

  • MLKL-IN-5
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    MLKL-IN-5

    CAS:
    <p>MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .</p>
    Formula:C18H20N6O4S
    Color and Shape:Solid
    Molecular weight:416.45

    Ref: TM-T73279

  • HPK1-IN-28
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    HPK1-IN-28

    CAS:
    <p>HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.</p>
    Formula:C25H22F3N5O4
    Color and Shape:Solid
    Molecular weight:513.47

    Ref: TM-T63553

  • JTP-70902
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    JTP-70902

    CAS:
    <p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>
    Formula:C24H21BrFN5O5S
    Color and Shape:Solid
    Molecular weight:590.42

    Ref: TM-T24222

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    Antifungal agent 46

    CAS:
    <p>Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].</p>
    Formula:C26H28BrF3N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:565.43

    Ref: TM-T74976

  • p38 MAP Kinase Inhibitor IV
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    p38 MAP Kinase Inhibitor IV

    CAS:
    <p>p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.</p>
    Formula:C12H4Cl6O4S
    Color and Shape:Solid
    Molecular weight:456.94

    Ref: TM-T36011

  • KRAS inhibitor-10
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    KRAS inhibitor-10

    CAS:
    <p>KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.</p>
    Formula:C30H37N3O5
    Color and Shape:Solid
    Molecular weight:519.63

    Ref: TM-T36761

  • KRAS G12C inhibitor 45
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    KRAS G12C inhibitor 45

    CAS:
    <p>KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .</p>
    Formula:C32H33F2N5O5S
    Color and Shape:Solid
    Molecular weight:637.7

    Ref: TM-T72336

  • JNK3 inhibitor-4
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    JNK3 inhibitor-4

    CAS:
    <p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>
    Formula:C28H27N7O
    Color and Shape:Solid
    Molecular weight:477.56

    Ref: TM-T72715

  • HPK1-IN-17
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    HPK1-IN-17

    CAS:
    <p>HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.</p>
    Formula:C26H28N6O
    Color and Shape:Solid
    Molecular weight:440.54

    Ref: TM-T62547

  • KRAS inhibitor-17
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    KRAS inhibitor-17

    CAS:
    <p>KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.</p>
    Formula:C21H18Cl2FN3O2S
    Color and Shape:Solid
    Molecular weight:466.36

    Ref: TM-T62981

  • BRAF V600E/CRAF-IN-2
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    BRAF V600E/CRAF-IN-2

    CAS:
    <p>Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.</p>
    Formula:C30H30F3N5O2
    Color and Shape:Solid
    Molecular weight:549.59

    Ref: TM-T63882

  • KRAS4b-PDEδ stabilizer C19
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    KRAS4b-PDEδ stabilizer C19

    CAS:
    <p>KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via</p>
    Formula:C18H20Cl2N2O3
    Color and Shape:Solid
    Molecular weight:383.27

    Ref: TM-T32419

  • SCH 51344
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    SCH 51344

    CAS:
    <p>SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].</p>
    Formula:C16H20N4O3
    Color and Shape:Solid
    Molecular weight:316.36

    Ref: TM-T21676

  • LX-3
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    LX-3

    CAS:
    <p>LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.</p>
    Formula:C20H13BrN4OS
    Color and Shape:Solid
    Molecular weight:437.31

    Ref: TM-T69321

  • KRAS G12C inhibitor 47
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    KRAS G12C inhibitor 47

    CAS:
    <p>KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.</p>
    Formula:C30H28ClFN4O3
    Color and Shape:Solid
    Molecular weight:547.02

    Ref: TM-T63863

  • SOS1-IN-3
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    SOS1-IN-3

    CAS:
    <p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>
    Formula:C21H21F3N4O
    Color and Shape:Solid
    Molecular weight:402.41

    Ref: TM-T61963

  • SOS1 activator 1
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    SOS1 activator 1

    CAS:
    <p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>
    Formula:C26H32ClFN6
    Color and Shape:Solid
    Molecular weight:483.02

    Ref: TM-T63201

  • 6-T-GDP
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    6-T-GDP

    CAS:
    <p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>
    Formula:C10H15N5O10P2S
    Color and Shape:Solid
    Molecular weight:459.27

    Ref: TM-T88704