MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 881 products of "MAPK"

Purity (%)

100

products per page.

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CMP3a
CAS:
- 2225902-88-3
CMP3a, a NEK2 inhibitor, hinders GBM in mice and enhances radiotherapy by disrupting EZH2.
Formula:C₂₈H₂₇F₃N₆O₂S
Color and Shape:Solid
Molecular weight:568.61
Ref: TM-T27052
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Ras inhibitor 134
CAS:
- 2648552-54-7
Ras inhibitor 134 can be used in studies about Ras.
Formula:C₂₃H₂₁ClFN₅O₃
Color and Shape:Soild
Molecular weight:469.9
Ref: TM-T77800
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KRAS inhibitor-12
CAS:
- 2230874-00-5
KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.
Formula:C₁₉H₁₆Cl₂FN₅OS
Color and Shape:Solid
Molecular weight:452.33
Ref: TM-T62751
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AZD4747
CAS:
- 2489226-14-2
AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
Formula:C₂₄H₂₂ClFN₂O₃
Purity:99.36%
Color and Shape:Solid
Molecular weight:440.89
Ref: TM-T79213
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KRAS G12C inhibitor 14
CAS:
- 2349393-95-7
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].
Formula:C₂₄H₁₉ClF₂N₄O₃
Purity:98%
Color and Shape:Solid
Molecular weight:484.88
Ref: TM-T11768
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L 731734
CAS:
- 149786-89-0
L 731734 is a farnesyltransferase inhibitor.
Formula:C₁₉H₃₈N₄O₃S
Color and Shape:Solid
Molecular weight:402.6
Ref: TM-T24350
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p38-α MAPK-IN-1
CAS:
- 443913-15-3
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.
Formula:C₂₇H₃₅N₅O₃
Purity:99.93%
Color and Shape:Solid
Molecular weight:477.6
Ref: TM-T12347
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KRAS G12C inhibitor 21
CAS:
- 2737269-61-1
KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.
Formula:C₃₄H₃₀ClN₃O₄
Color and Shape:Solid
Molecular weight:580.07
Ref: TM-T64097
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AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective
Formula:C₂₉H₂₈ClN₅O
Purity:98%
Color and Shape:Solid
Molecular weight:498.02
Ref: TM-T10298
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KRAS G12C inhibitor 13
CAS:
- 2241719-75-3
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
Formula:C₄₀H₄₆F₃N₇O₄
Purity:98%
Color and Shape:Solid
Molecular weight:745.83
Ref: TM-T11767
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RPR203494
CAS:
- 218160-26-0
RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.
Formula:C₂₆H₂₉FN₆O₄
Color and Shape:Solid
Molecular weight:508.54
Ref: TM-T69832
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HPK1-IN-37
CAS:
- 2766481-68-7
HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.
Formula:C₂₇H₃₅N₇O₄
Color and Shape:Solid
Molecular weight:521.61
Ref: TM-T79787
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PROTAC KRAS G12C degrader-3
CAS:
- 2768099-51-8
PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].
Formula:C₆₃H₇₅ClN₁₄O₆
Purity:98%
Color and Shape:Solid
Molecular weight:1159.81
Ref: TM-T79148
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ERK1/2 inhibitor 8
CAS:
- 2648368-43-6
ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).
Formula:C₂₃H₂₀ClN₇O₂S
Color and Shape:Solid
Molecular weight:493.97
Ref: TM-T63331
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ERK1/2 inhibitor 7
CAS:
- 2648455-13-2
ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).
Formula:C₂₃H₂₂FN₇OS
Color and Shape:Solid
Molecular weight:463.53
Ref: TM-T62933
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KRAS G12C inhibitor 51
CAS:
- 2762632-78-8
KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.
Formula:C₃₃H₃₅FN₆O₃
Color and Shape:Solid
Molecular weight:582.67
Ref: TM-T64115
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Deltasonamide 1
CAS:
- 2088485-33-8
Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.
Formula:C₃₀H₃₉ClN₆O₄S₂
Color and Shape:Solid
Molecular weight:647.25
Ref: TM-T23976
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(aS)-PH-797804
CAS:
- 1358027-80-1
(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].
Formula:C₂₂H₁₉BrF₂N₂O₃
Color and Shape:Solid
Molecular weight:477.3
Ref: TM-T84894
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SOS1-IN-8
CAS:
- 2759387-92-1
SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).
Formula:C₂₄H₂₆F₃N₃O₄
Color and Shape:Solid
Molecular weight:477.48
Ref: TM-T63118
+ Info
KRAS G12C mutant protein inhibitor A-1
CAS:
- 2658538-04-4
KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.
Formula:C₃₁H₂₆ClF₄N₇O₂
Color and Shape:Solid
Molecular weight:640.03
Ref: TM-T77805

MAPK

Found 881 products of "MAPK"

CMP3a

Ref: TM-T27052

Ras inhibitor 134

Ref: TM-T77800

KRAS inhibitor-12

Ref: TM-T62751

AZD4747

Ref: TM-T79213

KRAS G12C inhibitor 14

Ref: TM-T11768

L 731734

Ref: TM-T24350

p38-α MAPK-IN-1

Ref: TM-T12347

KRAS G12C inhibitor 21

Ref: TM-T64097

AMG-548 hydrochloride (864249-60-5 free base)

Ref: TM-T10298

KRAS G12C inhibitor 13

Ref: TM-T11767

RPR203494

Ref: TM-T69832

HPK1-IN-37

Ref: TM-T79787

PROTAC KRAS G12C degrader-3

Ref: TM-T79148

ERK1/2 inhibitor 8

Ref: TM-T63331

ERK1/2 inhibitor 7

Ref: TM-T62933

KRAS G12C inhibitor 51

Ref: TM-T64115

Deltasonamide 1

Ref: TM-T23976

(aS)-PH-797804

Ref: TM-T84894

SOS1-IN-8

Ref: TM-T63118

KRAS G12C mutant protein inhibitor A-1

Ref: TM-T77805