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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 881 products of "MAPK"

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  • KRAS G12C inhibitor 61
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    KRAS G12C inhibitor 61

    CAS:
    <p>KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.</p>
    Formula:C31H33ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:590.09

    Ref: TM-T79808

  • Uplarafenib
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    Uplarafenib

    CAS:
    Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.
    Formula:C22H21F3N4O4S
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:494.49

    Ref: TM-T63333

  • KRas G12C inhibitor 1
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    KRas G12C inhibitor 1

    CAS:
    KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
    Formula:C31H38N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:542.67

    Ref: TM-T11776

  • TNIK&MAP4K4-IN-1
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    TNIK&MAP4K4-IN-1

    CAS:
    <p>TNIK&amp;MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and &lt;10 nM, respectively, in human</p>
    Formula:C25H23FN4O3
    Color and Shape:Solid
    Molecular weight:446.47

    Ref: TM-T79794

  • JNK3 inhibitor-3
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    JNK3 inhibitor-3

    CAS:
    <p>JNK3 Inhibitor-3 selectively blocks JNK3 (&gt;4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.</p>
    Formula:C26H25N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:467.52

    Ref: TM-T72714

  • MEK-IN-6 hydrate
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    MEK-IN-6 hydrate

    CAS:
    <p>MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].</p>
    Formula:C18H22FN3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:411.45

    Ref: TM-T79048

  • MEK-IN-6
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    MEK-IN-6

    CAS:
    <p>MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making it</p>
    Formula:C18H20FN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.43

    Ref: TM-T79047

  • KRAS G12C inhibitor 34
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    KRAS G12C inhibitor 34

    CAS:
    <p>KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.</p>
    Formula:C32H32ClN5O3
    Color and Shape:Solid
    Molecular weight:570.08

    Ref: TM-T64033

  • SOS1-IN-7
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    SOS1-IN-7

    CAS:
    <p>SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).</p>
    Formula:C23H25F3N4O3
    Color and Shape:Solid
    Molecular weight:462.46

    Ref: TM-T62923

  • Laxiflorin B
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    Laxiflorin B

    CAS:
    <p>Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].</p>
    Formula:C20H24O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:344.4

    Ref: TM-T79785

  • SOS1-IN-16
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    SOS1-IN-16

    CAS:
    <p>SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of</p>
    Formula:C30H31F3N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:552.59

    Ref: TM-T79183

  • KRAS G12C inhibitor 5
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    KRAS G12C inhibitor 5

    CAS:
    <p>KRAS G12C inhibitor 5 is a KRas G12C inhibitor.</p>
    Formula:C32H37N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:551.68

    Ref: TM-T11780

  • B-Raf IN 5
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    B-Raf IN 5

    CAS:
    <p>B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR.</p>
    Formula:C23H18ClF3N6O3S2
    Color and Shape:Solid
    Molecular weight:583.01

    Ref: TM-T64116

  • pan-KRAS-IN-4
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    pan-KRAS-IN-4

    CAS:
    <p>Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].</p>
    Formula:C36H34F2N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:636.69

    Ref: TM-T79799

  • HPK1-IN-9
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    HPK1-IN-9

    CAS:
    <p>HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)</p>
    Formula:C30H33N7O2
    Color and Shape:Solid
    Molecular weight:523.63

    Ref: TM-T63670

  • KRAS inhibitor-18
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    KRAS inhibitor-18

    CAS:
    <p>KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.</p>
    Formula:C20H15ClF3N3O2S
    Color and Shape:Solid
    Molecular weight:453.87

    Ref: TM-T62784

  • HPK1-IN-10
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    HPK1-IN-10

    CAS:
    <p>HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.</p>
    Formula:C31H34N6O2
    Color and Shape:Solid
    Molecular weight:522.64

    Ref: TM-T63659

  • SOS1/KRAS-IN-1
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    SOS1/KRAS-IN-1

    CAS:
    <p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>
    Formula:C24H26F3N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:457.49

    Ref: TM-T79162

  • KRAS G12C inhibitor 25
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    KRAS G12C inhibitor 25

    CAS:
    <p>KRAS G12C inhibitor 25 blocks SOS1-mediated GDP/GTP swap in KRAS-G12C mutants; IC50: 0.48 nM (WO2021216770A1, comp. 3).</p>
    Formula:C32H41N7O2
    Color and Shape:Solid
    Molecular weight:555.71

    Ref: TM-T63927

  • GNE 220 hydrochloride
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    GNE 220 hydrochloride

    CAS:
    <p>GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>
    Formula:C25H27ClN8
    Color and Shape:Solid
    Molecular weight:474.99

    Ref: TM-T63095