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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 881 products of "MAPK"

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  • SOS1-IN-5
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    SOS1-IN-5

    CAS:
    <p>SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.</p>
    Formula:C26H31F3N4O5
    Color and Shape:Solid
    Molecular weight:536.54

    Ref: TM-T63781

  • SKF-86002 dihydrochloride
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    SKF-86002 dihydrochloride

    CAS:
    <p>p38 MAP kinase inhibitor</p>
    Formula:C16H14Cl2FN3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:370.27

    Ref: TM-T23365

  • HPK1-IN-33
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    HPK1-IN-33

    CAS:
    <p>HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.</p>
    Formula:C18H16ClFN6
    Color and Shape:Solid
    Molecular weight:370.81

    Ref: TM-T73149

  • K-Ras G12C-IN-1
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    K-Ras G12C-IN-1

    CAS:
    K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
    Formula:C22H23Cl2N3O3
    Color and Shape:Solid
    Molecular weight:448.34

    Ref: TM-T11735

  • KRAS G12C inhibitor 53
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    KRAS G12C inhibitor 53

    CAS:
    <p>KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.</p>
    Formula:C21H14ClF2N5O2
    Color and Shape:Solid
    Molecular weight:441.82

    Ref: TM-T62566

  • HPK1-IN-11
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    HPK1-IN-11

    CAS:
    <p>HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.</p>
    Formula:C27H25N5O2
    Color and Shape:Solid
    Molecular weight:451.52

    Ref: TM-T62742

  • HPK1-IN-27
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    HPK1-IN-27

    CAS:
    <p>HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.</p>
    Formula:C26H23F3N4O4
    Color and Shape:Solid
    Molecular weight:512.48

    Ref: TM-T63541

  • SOS1-IN-13
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    SOS1-IN-13

    CAS:
    <p>SOS1-IN-13 inhibits SOS1 (IC50: 6.5 nM) and pERK (327 nM); potential in cancer research.</p>
    Formula:C21H22F3N3O2
    Color and Shape:Solid
    Molecular weight:405.41

    Ref: TM-T62003

  • KRAS G12C inhibitor 32
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    KRAS G12C inhibitor 32

    CAS:
    <p>KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].</p>
    Formula:C29H30Cl3FN6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:635.94

    Ref: TM-T72335

  • ZG1077
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    ZG1077

    CAS:
    <p>ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.</p>
    Formula:C33H33F2N5O5S
    Color and Shape:Solid
    Molecular weight:649.71

    Ref: TM-T73510

  • FGTI-2734 mesylate (1247018-19-4 free base)
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    FGTI-2734 mesylate (1247018-19-4 free base)

    CAS:
    <p>FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.</p>
    Formula:C27H35FN6O5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:606.73

    Ref: TM-T11282L

  • ERK-IN-2 free base
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    ERK-IN-2 free base

    CAS:
    <p>ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at &gt;10 μM.</p>
    Formula:C16H17N5O2
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T72517

  • p38 Kinase inhibitor 4
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    p38 Kinase inhibitor 4

    CAS:
    <p>Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].</p>
    Formula:C12H9Cl2N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:282.13

    Ref: TM-T79028

  • pan-KRAS-IN-3
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    pan-KRAS-IN-3

    CAS:
    <p>Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].</p>
    Formula:C33H32F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:587.63

    Ref: TM-T79814

  • SB 203580 sulfone
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    SB 203580 sulfone

    CAS:
    <p>SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].</p>
    Formula:C21H16FN3O2S
    Color and Shape:Solid
    Molecular weight:393.43

    Ref: TM-T84519

  • AZ-TAK1
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    AZ-TAK1

    CAS:
    <p>"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."</p>
    Formula:C25H28FN7O2
    Color and Shape:Solid
    Molecular weight:477.53

    Ref: TM-T70741

  • HPK1-IN-35
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    HPK1-IN-35

    CAS:
    <p>HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.</p>
    Formula:C30H32N8O3S
    Color and Shape:Solid
    Molecular weight:584.69

    Ref: TM-T78688

  • Rac1-IN-3
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    Rac1-IN-3

    CAS:
    <p>Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].</p>
    Formula:C21H23N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:405.45

    Ref: TM-T79869

  • AMG-548 dihydrochloride (864249-60-5 free base)
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    AMG-548 dihydrochloride (864249-60-5 free base)

    <p>AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; &gt;&gt; p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.</p>
    Formula:C29H29Cl2N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:534.48

    Ref: TM-T10298L2

  • BI-0474
    Targetmol
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    BI-0474

    CAS:
    <p>BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells &amp; lung cancer model, for cancer research.</p>
    Formula:C30H37N9O2S
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:587.74

    Ref: TM-T69529